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Items: 1 to 20 of 140

1.

Simultaneous analysis of multiple monoclonal antibody biotherapeutics by LC-MS/MS method in rat plasma following cassette-dosing.

Li H, Ortiz R, Tran LT, Salimi-Moosavi H, Malella J, James CA, Lee JW.

AAPS J. 2013 Apr;15(2):337-46. doi: 10.1208/s12248-012-9435-5. Epub 2012 Dec 12.

2.

General LC-MS/MS method approach to quantify therapeutic monoclonal antibodies using a common whole antibody internal standard with application to preclinical studies.

Li H, Ortiz R, Tran L, Hall M, Spahr C, Walker K, Laudemann J, Miller S, Salimi-Moosavi H, Lee JW.

Anal Chem. 2012 Feb 7;84(3):1267-73. doi: 10.1021/ac202792n. Epub 2012 Jan 25.

PMID:
22243404
3.

A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies.

Furlong MT, Ouyang Z, Wu S, Tamura J, Olah T, Tymiak A, Jemal M.

Biomed Chromatogr. 2012 Aug;26(8):1024-32. doi: 10.1002/bmc.2759. Epub 2012 May 24.

PMID:
22623136
4.

Comparison of bioanalytical methods for the quantitation of PEGylated human insulin.

de Dios K, Manibusan A, Marsden R, Pinkstaff J.

J Immunol Methods. 2013 Oct 31;396(1-2):1-7. doi: 10.1016/j.jim.2013.07.007. Epub 2013 Aug 6.

PMID:
23933323
5.

Towards absolute quantification of therapeutic monoclonal antibody in serum by LC-MS/MS using isotope-labeled antibody standard and protein cleavage isotope dilution mass spectrometry.

Heudi O, Barteau S, Zimmer D, Schmidt J, Bill K, Lehmann N, Bauer C, Kretz O.

Anal Chem. 2008 Jun 1;80(11):4200-7. doi: 10.1021/ac800205s. Epub 2008 May 9.

PMID:
18465883
6.

Liquid chromatography coupled with tandem mass spectrometry for the bioanalysis of proteins in drug development: practical considerations in assay development and validation.

Liu G, Ji QC, Dodge R, Sun H, Shuster D, Zhao Q, Arnold M.

J Chromatogr A. 2013 Apr 5;1284:155-62. doi: 10.1016/j.chroma.2013.02.016. Epub 2013 Feb 13.

PMID:
23466204
7.

Critical role of bioanalytical strategies in investigation of clinical PK observations, a Phase I case study.

Peng K, Xu K, Liu L, Hendricks R, Delarosa R, Erickson R, Budha N, Leabman M, Song A, Kaur S, Fischer SK.

MAbs. 2014;6(6):1500-8. doi: 10.4161/mabs.36208.

8.

Internal standards in the quantitative determination of protein biopharmaceuticals using liquid chromatography coupled to mass spectrometry.

Bronsema KJ, Bischoff R, van de Merbel NC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 15;893-894:1-14. doi: 10.1016/j.jchromb.2012.02.021. Epub 2012 Feb 21. Review.

PMID:
22426285
9.

A multiplexed hybrid LC-MS/MS pharmacokinetic assay to measure two co-administered monoclonal antibodies in a clinical study.

Xu K, Liu L, Maia M, Li J, Lowe J, Song A, Kaur S.

Bioanalysis. 2014;6(13):1781-94. doi: 10.4155/bio.14.142.

PMID:
25157485
10.

Qualification and application of a liquid chromatography-tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction.

Shin YG, Hamm L, Murakami S, Buirst K, Buonarati MH, Cox A, Regal K, Hunt KW, Scearce-Levie K, Watts RJ, Liu X.

Arch Pharm Res. 2014 May;37(5):636-44. doi: 10.1007/s12272-013-0215-2. Epub 2013 Jul 26.

PMID:
23888333
11.

Use of high-resolution mass spectrometry to investigate a metabolite interference during liquid chromatography/tandem mass spectrometric quantification of a small molecule in toxicokinetic study samples.

Furlong M, Bessire A, Song W, Huntington C, Groeber E.

Rapid Commun Mass Spectrom. 2010 Jul 15;24(13):1902-10. doi: 10.1002/rcm.4587.

PMID:
20533320
12.

Comparison of a stable isotope labeled (SIL) peptide and an extended SIL peptide as internal standards to track digestion variability of an unstable signature peptide during quantification of a cancer biomarker, human osteopontin, from plasma using capillary microflow LC-MS/MS.

Faria M, Halquist MS, Yuan M, Mylott W Jr, Jenkins RG, Karnes HT.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 15;1001:156-68. doi: 10.1016/j.jchromb.2015.05.040. Epub 2015 Jul 26.

PMID:
26279007
13.

Bioanalytical platform comparison using a generic human IgG PK assay format.

Leary BA, Lawrence-Henderson R, Mallozzi C, Fernandez Ocaña M, Duriga N, O'Hara DM, Kavosi M, Qu Q, Joyce AP.

J Immunol Methods. 2013 Nov 29;397(1-2):28-36. doi: 10.1016/j.jim.2013.08.009. Epub 2013 Aug 29.

PMID:
23994108
14.

High-sensitivity LC-MS/MS quantification of peptides and proteins in complex biological samples: the impact of enzymatic digestion and internal standard selection on method performance.

Bronsema KJ, Bischoff R, van de Merbel NC.

Anal Chem. 2013 Oct 15;85(20):9528-35. doi: 10.1021/ac4015116. Epub 2013 Sep 25.

PMID:
24010948
16.

Fully validated LC-MS/MS assay for the simultaneous quantitation of coadministered therapeutic antibodies in cynomolgus monkey serum.

Jiang H, Zeng J, Titsch C, Voronin K, Akinsanya B, Luo L, Shen H, Desai DD, Allentoff A, Aubry AF, Desilva BS, Arnold ME.

Anal Chem. 2013 Oct 15;85(20):9859-67. doi: 10.1021/ac402420v. Epub 2013 Sep 26.

PMID:
24024648
17.

Generic automated method for liquid chromatography-multiple reaction monitoring mass spectrometry based monoclonal antibody quantitation for preclinical pharmacokinetic studies.

Zhang Q, Spellman DS, Song Y, Choi B, Hatcher NG, Tomazela D, Beaumont M, Tabrizifard M, Prabhavalkar D, Seghezzi W, Harrelson J, Bateman KP.

Anal Chem. 2014 Sep 2;86(17):8776-84. doi: 10.1021/ac5019827. Epub 2014 Aug 14.

PMID:
25010922
18.

A validated enantioselective LC-MS/MS assay for the simultaneous determination of carvedilol and its pharmacologically active 4'-hydroxyphenyl metabolite in human plasma: application to a clinical pharmacokinetic study.

Furlong MT, He B, Mylott W, Zhao S, Mariannino T, Shen J, Stouffer B.

J Pharm Biomed Anal. 2012 Nov;70:574-9. doi: 10.1016/j.jpba.2012.05.026. Epub 2012 May 30.

PMID:
22709607
19.
20.

Guanidinated protein internal standard for immunoaffinity-liquid chromatography/tandem mass spectrometry quantitation of protein therapeutics.

Yang W, Kernstock R, Simmons N, Alak A.

Rapid Commun Mass Spectrom. 2014 Jul 15;28(13):1489-500. doi: 10.1002/rcm.6924.

PMID:
24861599
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