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The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor- and interleukin-1-induced nuclear factor-κB activation by dephosphorylating the protein kinase TAK1.

Zheng H, Li Q, Chen R, Zhang J, Ran Y, He X, Li S, Shu HB.

J Biol Chem. 2013 Jan 11;288(2):819-25. doi: 10.1074/jbc.M112.412643. Epub 2012 Dec 10.


Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.

Yang CY, Li JP, Chiu LL, Lan JL, Chen DY, Chuang HC, Huang CY, Tan TH.

J Immunol. 2014 Feb 15;192(4):1547-57. doi: 10.4049/jimmunol.1300989. Epub 2014 Jan 8.


ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction.

Mochida Y, Takeda K, Saitoh M, Nishitoh H, Amagasa T, Ninomiya-Tsuji J, Matsumoto K, Ichijo H.

J Biol Chem. 2000 Oct 20;275(42):32747-52.


Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.

Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Chang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J.

J Biol Chem. 2010 Feb 19;285(8):5347-60. doi: 10.1074/jbc.M109.076976. Epub 2009 Dec 28.


WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.

Gao D, Wang R, Li B, Yang Y, Zhai Z, Chen DY.

Cell Mol Life Sci. 2009 Aug;66(15):2573-84. doi: 10.1007/s00018-009-0059-6. Epub 2009 Jun 12.


Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation.

Gu M, Ouyang C, Lin W, Zhang T, Cao X, Xia Z, Wang X.

J Immunol. 2014 Mar 15;192(6):2846-56. doi: 10.4049/jimmunol.1302537. Epub 2014 Feb 17. Erratum in: J Immunol. 2015 Aug 1;195(3):1331-2.


Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination.

Li Q, Yan J, Mao AP, Li C, Ran Y, Shu HB, Wang YY.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19341-6. doi: 10.1073/pnas.1110946108. Epub 2011 Nov 14.


Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases.

Brechter AB, Persson E, Lundgren I, Lerner UH.

Bone. 2008 Jul;43(1):72-83. doi: 10.1016/j.bone.2008.02.003. Epub 2008 Mar 10.


Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression.

Yu Y, Ge N, Xie M, Sun W, Burlingame S, Pass AK, Nuchtern JG, Zhang D, Fu S, Schneider MD, Fan J, Yang J.

J Biol Chem. 2008 Sep 5;283(36):24497-505. doi: 10.1074/jbc.M802825200. Epub 2008 Jul 10.


A mechanism for the suppression of interleukin-1-induced nuclear factor kappaB activation by protein phosphatase 2Ceta-2.

Henmi T, Amano K, Nagaura Y, Matsumoto K, Echigo S, Tamura S, Kobayashi T.

Biochem J. 2009 Sep 14;423(1):71-8. doi: 10.1042/BJ20090208.


TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers.

Freudlsperger C, Bian Y, Contag Wise S, Burnett J, Coupar J, Yang X, Chen Z, Van Waes C.

Oncogene. 2013 Mar 21;32(12):1549-59. doi: 10.1038/onc.2012.171. Epub 2012 May 28.


Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.

Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM.

Mol Cell Biol. 2001 Nov;21(21):7207-17.


AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals.

Kim SY, Jeong S, Jung E, Baik KH, Chang MH, Kim SA, Shim JH, Chun E, Lee KY.

Cell Death Dis. 2012 Jul 26;3:e357. doi: 10.1038/cddis.2012.95.


USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation.

Fan YH, Yu Y, Mao RF, Tan XJ, Xu GF, Zhang H, Lu XB, Fu SB, Yang J.

Cell Death Differ. 2011 Oct;18(10):1547-60. doi: 10.1038/cdd.2011.11. Epub 2011 Feb 18.


Heat shock protein 90 (Hsp90) regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta-induced cell signaling.

Shi L, Zhang Z, Fang S, Xu J, Liu J, Shen J, Fang F, Luo L, Yin Z.

Mol Immunol. 2009 Feb;46(4):541-50. doi: 10.1016/j.molimm.2008.07.019. Epub 2008 Oct 31.

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