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Items: 1 to 20 of 138

1.

Toward animal cell culture-based influenza vaccine design: viral hemagglutinin N-glycosylation markedly impacts immunogenicity.

Hütter J, Rödig JV, Höper D, Seeberger PH, Reichl U, Rapp E, Lepenies B.

J Immunol. 2013 Jan 1;190(1):220-30. doi: 10.4049/jimmunol.1201060. Epub 2012 Dec 5.

2.

Impact of cultivation conditions on N-glycosylation of influenza virus a hemagglutinin produced in MDCK cell culture.

Rödig JV, Rapp E, Bohne J, Kampe M, Kaffka H, Bock A, Genzel Y, Reichl U.

Biotechnol Bioeng. 2013 Jun;110(6):1691-703. doi: 10.1002/bit.24834. Epub 2013 Feb 4.

PMID:
23297157
3.

Impact of host cell line adaptation on quasispecies composition and glycosylation of influenza A virus hemagglutinin.

Roedig JV, Rapp E, Höper D, Genzel Y, Reichl U.

PLoS One. 2011;6(12):e27989. doi: 10.1371/journal.pone.0027989. Epub 2011 Dec 7.

4.

Glycan analysis in cell culture-based influenza vaccine production: influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin.

Schwarzer J, Rapp E, Hennig R, Genzel Y, Jordan I, Sandig V, Reichl U.

Vaccine. 2009 Jul 9;27(32):4325-36. doi: 10.1016/j.vaccine.2009.04.076. Epub 2009 May 14.

PMID:
19410619
5.

Addition of glycosylation to influenza A virus hemagglutinin modulates antibody-mediated recognition of H1N1 2009 pandemic viruses.

Job ER, Deng YM, Barfod KK, Tate MD, Caldwell N, Reddiex S, Maurer-Stroh S, Brooks AG, Reading PC.

J Immunol. 2013 Mar 1;190(5):2169-77. doi: 10.4049/jimmunol.1202433. Epub 2013 Jan 30.

6.

Cell culture-derived influenza vaccines from Vero cells: a new horizon for vaccine production.

Montomoli E, Khadang B, Piccirella S, Trombetta C, Mennitto E, Manini I, Stanzani V, Lapini G.

Expert Rev Vaccines. 2012 May;11(5):587-94. doi: 10.1586/erv.12.24. Review.

PMID:
22827244
7.

Genetic requirement for hemagglutinin glycosylation and its implications for influenza A H1N1 virus evolution.

Kim JI, Lee I, Park S, Hwang MW, Bae JY, Lee S, Heo J, Park MS, García-Sastre A, Park MS.

J Virol. 2013 Jul;87(13):7539-49. doi: 10.1128/JVI.00373-13. Epub 2013 May 1.

8.

Egg- or cell culture-derived hemagglutinin mutations impair virus stability and antigen content of inactivated influenza vaccines.

Nakowitsch S, Waltenberger AM, Wressnigg N, Ferstl N, Triendl A, Kiefmann B, Montomoli E, Lapini G, Sergeeva M, Muster T, Romanova JR.

Biotechnol J. 2014 Mar;9(3):405-14. doi: 10.1002/biot.201300225. Epub 2013 Dec 10. Erratum in: Biotechnol J. 2014 Apr;9(4):585.

PMID:
24323790
9.

Immune effects against influenza A virus and a novel DNA vaccine with co-expression of haemagglutinin- and neuraminidase-encoding genes.

Zhang W, Li W, Li Y, Li H, Wang B, Wang F, Zhu Y, Jiang Z, Zhong L, Li M.

J Med Microbiol. 2009 Jul;58(Pt 7):845-54. doi: 10.1099/jmm.0.006825-0. Epub 2009 Jun 4.

PMID:
19498203
10.

Immunogenicity and protective efficacy in mice of influenza B virus vaccines grown in mammalian cells or embryonated chicken eggs.

Alymova IV, Kodihalli S, Govorkova EA, Fanget B, Gerdil C, Webster RG.

J Virol. 1998 May;72(5):4472-7.

11.

MDCK and Vero cells for influenza virus vaccine production: a one-to-one comparison up to lab-scale bioreactor cultivation.

Genzel Y, Dietzsch C, Rapp E, Schwarzer J, Reichl U.

Appl Microbiol Biotechnol. 2010 Sep;88(2):461-75. doi: 10.1007/s00253-010-2742-9. Epub 2010 Jul 9.

PMID:
20617311
12.

Comparison of immunogenicity of cell-and egg-passaged viruses for manufacturing MDCK cell culture-based influenza vaccines.

Shin D, Park KJ, Lee H, Cho EY, Kim MS, Hwang MH, Kim SI, Ahn DH.

Virus Res. 2015 Jun 2;204:40-6. doi: 10.1016/j.virusres.2015.04.005. Epub 2015 Apr 17.

PMID:
25892718
13.

Synthetic generation of influenza vaccine viruses for rapid response to pandemics.

Dormitzer PR, Suphaphiphat P, Gibson DG, Wentworth DE, Stockwell TB, Algire MA, Alperovich N, Barro M, Brown DM, Craig S, Dattilo BM, Denisova EA, De Souza I, Eickmann M, Dugan VG, Ferrari A, Gomila RC, Han L, Judge C, Mane S, Matrosovich M, Merryman C, Palladino G, Palmer GA, Spencer T, Strecker T, Trusheim H, Uhlendorff J, Wen Y, Yee AC, Zaveri J, Zhou B, Becker S, Donabedian A, Mason PW, Glass JI, Rappuoli R, Venter JC.

Sci Transl Med. 2013 May 15;5(185):185ra68. doi: 10.1126/scitranslmed.3006368.

14.

Structural and evolutionary characteristics of HA, NA, NS and M genes of clinical influenza A/H3N2 viruses passaged in human and canine cells.

Zhirnov OP, Vorobjeva IV, Saphonova OA, Poyarkov SV, Ovcharenko AV, Anhlan D, Malyshev NA.

J Clin Virol. 2009 Aug;45(4):322-33. doi: 10.1016/j.jcv.2009.05.030.

PMID:
19546028
15.

An influenza A/H1N1/2009 hemagglutinin vaccine produced in Escherichia coli.

Aguilar-Yáñez JM, Portillo-Lara R, Mendoza-Ochoa GI, García-Echauri SA, López-Pacheco F, Bulnes-Abundis D, Salgado-Gallegos J, Lara-Mayorga IM, Webb-Vargas Y, León-Angel FO, Rivero-Aranda RE, Oropeza-Almazán Y, Ruiz-Palacios GM, Zertuche-Guerra MI, DuBois RM, White SW, Schultz-Cherry S, Russell CJ, Alvarez MM.

PLoS One. 2010 Jul 22;5(7):e11694. doi: 10.1371/journal.pone.0011694.

16.

Continuous cell lines as a production system for influenza vaccines.

Genzel Y, Reichl U.

Expert Rev Vaccines. 2009 Dec;8(12):1681-92. doi: 10.1586/erv.09.128. Review.

PMID:
19943763
17.

Comparative glycomics analysis of influenza Hemagglutinin (H5N1) produced in vaccine relevant cell platforms.

An Y, Rininger JA, Jarvis DL, Jing X, Ye Z, Aumiller JJ, Eichelberger M, Cipollo JF.

J Proteome Res. 2013 Aug 2;12(8):3707-20. doi: 10.1021/pr400329k. Epub 2013 Jul 24.

18.

Immunogenicity and safety of H1N1 influenza hemagglutinin protein expressed in a baculovirus system.

Na HN, Kim KH, Song MK, Park HL, Lee EY, Shim SH, Park S, Nam JH.

Microbiol Immunol. 2013 Sep;57(9):660-4. doi: 10.1111/1348-0421.12079.

19.

Application of deglycosylation and electrophoresis to the quantification of influenza viral hemagglutinins facilitating the production of 2009 pandemic influenza (H1N1) vaccines at multiple manufacturing sites in China.

Li C, Shao M, Cui X, Song Y, Li J, Yuan L, Fang H, Liang Z, Cyr TD, Li F, Li X, Wang J.

Biologicals. 2010 Mar;38(2):284-9. doi: 10.1016/j.biologicals.2009.12.004. Epub 2010 Jan 13.

PMID:
20074976
20.

Antigenic alteration of influenza B virus associated with loss of a glycosylation site due to host-cell adaptation.

Saito T, Nakaya Y, Suzuki T, Ito R, Saito T, Saito H, Takao S, Sahara K, Odagiri T, Murata T, Usui T, Suzuki Y, Tashiro M.

J Med Virol. 2004 Oct;74(2):336-43.

PMID:
15332284
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