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Identification of Oct4-activating compounds that enhance reprogramming efficiency.

Li W, Tian E, Chen ZX, Sun G, Ye P, Yang S, Lu D, Xie J, Ho TV, Tsark WM, Wang C, Horne DA, Riggs AD, Yip ML, Shi Y.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8. doi: 10.1073/pnas.1219181110. Epub 2012 Dec 3.


Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming.

Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, Kou X, Zhang Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T, Gao S.

Cell Stem Cell. 2013 Apr 4;12(4):453-69. doi: 10.1016/j.stem.2013.02.005. Epub 2013 Mar 14.


Characterization of Oct4-GFP spermatogonial stem cell line and its application in the reprogramming studies.

Youn H, Kim SH, Choi KA, Kim S.

J Cell Biochem. 2013 Apr;114(4):920-8. doi: 10.1002/jcb.24431.


Reprogramming of mouse fibroblasts into induced pluripotent stem cells with Nanog.

Moon JH, Yun W, Kim J, Hyeon S, Kang PJ, Park G, Kim A, Oh S, Whang KY, Kim DW, Yoon BS, You S.

Biochem Biophys Res Commun. 2013 Feb 15;431(3):444-9. doi: 10.1016/j.bbrc.2012.12.149. Epub 2013 Jan 16.


Zic3 enhances the generation of mouse induced pluripotent stem cells.

Declercq J, Sheshadri P, Verfaillie CM, Kumar A.

Stem Cells Dev. 2013 Jul 15;22(14):2017-25. doi: 10.1089/scd.2012.0651. Epub 2013 Mar 28.


ONSL and OSKM cocktails act synergistically in reprogramming human somatic cells into induced pluripotent stem cells.

Jung L, Tropel P, Moal Y, Teletin M, Jeandidier E, Gayon R, Himmelspach C, Bello F, André C, Tosch A, Mansouri A, Bruant-Rodier C, Bouillé P, Viville S.

Mol Hum Reprod. 2014 Jun;20(6):538-49. doi: 10.1093/molehr/gau012. Epub 2014 Feb 5.


Inhibition of transforming growth factor β (TGF-β) signaling can substitute for Oct4 protein in reprogramming and maintain pluripotency.

Tan F, Qian C, Tang K, Abd-Allah SM, Jing N.

J Biol Chem. 2015 Feb 13;290(7):4500-11. doi: 10.1074/jbc.M114.609016. Epub 2014 Dec 29.


OCT4 activity during conversion of human intermediately reprogrammed stem cells to iPSCs through mesenchymal-epithelial transition.

Teshigawara R, Hirano K, Nagata S, Ainscough J, Tada T.

Development. 2016 Jan 1;143(1):15-23. doi: 10.1242/dev.130344. Epub 2015 Dec 10.


Optimal reprogramming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cells.

Tiemann U, Sgodda M, Warlich E, Ballmaier M, Schöler HR, Schambach A, Cantz T.

Cytometry A. 2011 Jun;79(6):426-35. doi: 10.1002/cyto.a.21072. Epub 2011 May 4.


Gata4 blocks somatic cell reprogramming by directly repressing Nanog.

Serrano F, Calatayud CF, Blazquez M, Torres J, Castell JV, Bort R.

Stem Cells. 2013 Jan;31(1):71-82. doi: 10.1002/stem.1272.


Poly(ADP-ribose) polymerase 1 regulates nuclear reprogramming and promotes iPSC generation without c-Myc.

Chiou SH, Jiang BH, Yu YL, Chou SJ, Tsai PH, Chang WC, Chen LK, Chen LH, Chien Y, Chiou GY.

J Exp Med. 2013 Jan 14;210(1):85-98. doi: 10.1084/jem.20121044. Epub 2012 Dec 31.


Nuclear reprogramming with a non-integrating human RNA virus.

Driscoll CB, Tonne JM, El Khatib M, Cattaneo R, Ikeda Y, Devaux P.

Stem Cell Res Ther. 2015 Mar 26;6:48. doi: 10.1186/s13287-015-0035-z.


A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells.

Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco OE, Cates JM, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R.

Eur Urol. 2013 Nov;64(5):753-61. doi: 10.1016/j.eururo.2013.03.054. Epub 2013 Apr 6.


Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules.

Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y, Deng H.

Cell Res. 2011 Jan;21(1):196-204. doi: 10.1038/cr.2010.142. Epub 2010 Oct 19.


Induced pluripotent stem cells at nanoscale.

Zeuschner D, Mildner K, Zaehres H, Schöler HR.

Stem Cells Dev. 2010 May;19(5):615-20. doi: 10.1089/scd.2009.0159.


Conversion of partially reprogrammed cells to fully pluripotent stem cells is associated with further activation of stem cell maintenance- and gamete generation-related genes.

Kim JS, Choi HW, Choi S, Seo HG, Moon SH, Chung HM, Do JT.

Stem Cells Dev. 2014 Nov 1;23(21):2637-48. doi: 10.1089/scd.2014.0020. Epub 2014 Aug 20.


The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.

Heng JC, Feng B, Han J, Jiang J, Kraus P, Ng JH, Orlov YL, Huss M, Yang L, Lufkin T, Lim B, Ng HH.

Cell Stem Cell. 2010 Feb 5;6(2):167-74. doi: 10.1016/j.stem.2009.12.009. Epub 2010 Jan 21.


ΔNp63 regulates select routes of reprogramming via multiple mechanisms.

Alexandrova EM, Petrenko O, Nemajerova A, Romano RA, Sinha S, Moll UM.

Cell Death Differ. 2013 Dec;20(12):1698-708. doi: 10.1038/cdd.2013.122. Epub 2013 Sep 6.


Small molecules facilitate rapid and synchronous iPSC generation.

Bar-Nur O, Brumbaugh J, Verheul C, Apostolou E, Pruteanu-Malinici I, Walsh RM, Ramaswamy S, Hochedlinger K.

Nat Methods. 2014 Nov;11(11):1170-6. doi: 10.1038/nmeth.3142. Epub 2014 Sep 24.


Generation of pig iPS cells: a model for cell therapy.

Montserrat N, Bahima EG, Batlle L, Häfner S, Rodrigues AM, González F, Izpisúa Belmonte JC.

J Cardiovasc Transl Res. 2011 Apr;4(2):121-30. doi: 10.1007/s12265-010-9233-3. Epub 2010 Nov 19. Erratum in: J Cardiovasc Transl Res. 2013 Apr;6(2):295-7.

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