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Results: 1 to 20 of 115

1.

Exploring the binding of peptidic West Nile virus NS2B-NS3 protease inhibitors by NMR.

Kang C, Gayen S, Wang W, Severin R, Chen AS, Lim HA, Chia CS, Schüller A, Doan DN, Poulsen A, Hill J, Vasudevan SG, Keller TH.

Antiviral Res. 2013 Feb;97(2):137-44. doi: 10.1016/j.antiviral.2012.11.008. Epub 2012 Dec 2.

PMID:
23211132
[PubMed - indexed for MEDLINE]
2.

NMR analysis of the dynamic exchange of the NS2B cofactor between open and closed conformations of the West Nile virus NS2B-NS3 protease.

Su XC, Ozawa K, Qi R, Vasudevan SG, Lim SP, Otting G.

PLoS Negl Trop Dis. 2009 Dec 8;3(12):e561. doi: 10.1371/journal.pntd.0000561.

PMID:
19997625
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U.

Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12.

PMID:
16532006
[PubMed - indexed for MEDLINE]
4.

West Nile Virus NS2B/NS3 protease as an antiviral target.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR.

Curr Med Chem. 2008;15(27):2771-84. Review.

PMID:
18991636
[PubMed - indexed for MEDLINE]
5.

West Nile Virus (WNV) protease and membrane interactions revealed by NMR spectroscopy.

Gayen S, Chen AS, Huang Q, Kang C.

Biochem Biophys Res Commun. 2012 Jul 13;423(4):799-804. doi: 10.1016/j.bbrc.2012.06.043. Epub 2012 Jun 16.

PMID:
22713461
[PubMed - indexed for MEDLINE]
6.

Homology modeling and molecular dynamics simulations of Dengue virus NS2B/NS3 protease: insight into molecular interaction.

Wichapong K, Pianwanit S, Sippl W, Kokpol S.

J Mol Recognit. 2010 May-Jun;23(3):283-300. doi: 10.1002/jmr.977.

PMID:
19693793
[PubMed - indexed for MEDLINE]
7.
8.

Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease.

Nall TA, Chappell KJ, Stoermer MJ, Fang NX, Tyndall JD, Young PR, Fairlie DP.

J Biol Chem. 2004 Nov 19;279(47):48535-42. Epub 2004 Aug 18.

PMID:
15322074
[PubMed - indexed for MEDLINE]
Free Article
9.

Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts.

de la Cruz L, Nguyen TH, Ozawa K, Shin J, Graham B, Huber T, Otting G.

J Am Chem Soc. 2011 Nov 30;133(47):19205-15. doi: 10.1021/ja208435s. Epub 2011 Nov 9.

PMID:
22007671
[PubMed - indexed for MEDLINE]
10.

Synthesis and in vitro evaluation of West Nile virus protease inhibitors based on the 2-{6-[2-(5-phenyl-4H-{1,2,4]triazol-3-ylsulfanyl)acetylamino]benzothiazol-2-ylsulfanyl}acetamide scaffold.

Samanta S, Lim TL, Lam Y.

ChemMedChem. 2013 Jun;8(6):994-1001. doi: 10.1002/cmdc.201300114. Epub 2013 Apr 25.

PMID:
23619931
[PubMed - indexed for MEDLINE]
11.

Mutagenesis of D80-82 and G83 residues in West Nile Virus NS2B: effects on NS2B-NS3 activity and viral replication.

Jia F, Fan J, Zhang B, Yuan Z.

Virol Sin. 2013 Feb;28(1):16-23. doi: 10.1007/s12250-013-3276-y. Epub 2013 Jan 16.

PMID:
23325418
[PubMed - indexed for MEDLINE]
12.

Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity.

Stoermer MJ, Chappell KJ, Liebscher S, Jensen CM, Gan CH, Gupta PK, Xu WJ, Young PR, Fairlie DP.

J Med Chem. 2008 Sep 25;51(18):5714-21. doi: 10.1021/jm800503y. Epub 2008 Aug 26.

PMID:
18729351
[PubMed - indexed for MEDLINE]
13.

NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B-NS3 protease.

Su XC, Ozawa K, Yagi H, Lim SP, Wen D, Ekonomiuk D, Huang D, Keller TH, Sonntag S, Caflisch A, Vasudevan SG, Otting G.

FEBS J. 2009 Aug;276(15):4244-55. doi: 10.1111/j.1742-4658.2009.07132.x. Epub 2009 Jul 3.

PMID:
19583774
[PubMed - indexed for MEDLINE]
14.

Novel agmatine dipeptide inhibitors against the West Nile virus NS2B/NS3 protease: a P3 and N-cap optimization study.

Lim HA, Ang MJ, Joy J, Poulsen A, Wu W, Ching SC, Hill J, Chia CS.

Eur J Med Chem. 2013 Apr;62:199-205. doi: 10.1016/j.ejmech.2012.12.043. Epub 2013 Jan 3.

PMID:
23353753
[PubMed - indexed for MEDLINE]
15.

Substrate inhibition kinetic model for West Nile virus NS2B-NS3 protease.

Tomlinson SM, Watowich SJ.

Biochemistry. 2008 Nov 11;47(45):11763-70. doi: 10.1021/bi801034f. Epub 2008 Oct 15.

PMID:
18855422
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Activation of the West Nile virus NS3 protease: molecular dynamics evidence for a conformational selection mechanism.

Ekonomiuk D, Caflisch A.

Protein Sci. 2009 May;18(5):1003-11. doi: 10.1002/pro.110.

PMID:
19388022
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR.

J Biol Chem. 2006 Dec 15;281(50):38448-58. Epub 2006 Oct 19.

PMID:
17052977
[PubMed - indexed for MEDLINE]
Free Article
18.

Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation.

Robin G, Chappell K, Stoermer MJ, Hu SH, Young PR, Fairlie DP, Martin JL.

J Mol Biol. 2009 Feb 6;385(5):1568-77. doi: 10.1016/j.jmb.2008.11.026. Epub 2008 Nov 25.

PMID:
19059417
[PubMed - indexed for MEDLINE]
19.

The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.

Chernov AV, Shiryaev SA, Aleshin AE, Ratnikov BI, Smith JW, Liddington RC, Strongin AY.

J Biol Chem. 2008 Jun 20;283(25):17270-8. doi: 10.1074/jbc.M801719200. Epub 2008 Apr 28.

PMID:
18442976
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses.

Shiryaev SA, Kozlov IA, Ratnikov BI, Smith JW, Lebl M, Strongin AY.

Biochem J. 2007 Feb 1;401(3):743-52.

PMID:
17067286
[PubMed - indexed for MEDLINE]
Free PMC Article

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