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Items: 1 to 20 of 119

1.

Highly enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines.

Zheng Y, Xue Z, Liu L, Shu C, Yuan W, Zhang X.

Org Biomol Chem. 2013 Jan 21;11(3):412-5. doi: 10.1039/c2ob26672e. Epub 2012 Dec 3.

PMID:
23208651
2.

Enantioselective synthesis of 4-substituted 4,5-dihydro-1H-[1,5]benzodiazepin-2(3H)-ones by the Lewis base-catalyzed hydrosilylation.

Chen X, Zheng Y, Shu C, Yuan W, Liu B, Zhang X.

J Org Chem. 2011 Nov 4;76(21):9109-15. doi: 10.1021/jo201334n. Epub 2011 Oct 7.

PMID:
21958202
3.

Synthesis of a series of novel chiral Lewis base catalysts and their application in promoting asymmetric hydrosilylation of β-enamino esters.

Chen X, Hu XY, Shu C, Zhang YH, Zheng YS, Jiang Y, Yuan WC, Liu B, Zhang XM.

Org Biomol Chem. 2013 May 21;11(19):3089-93. doi: 10.1039/c3ob40430g. Epub 2013 Apr 5.

PMID:
23563603
4.

An organocatalyst bearing stereogenic carbon and sulfur centers as an efficient promoter for enantioselective hydrosilylation of 1,4-benzooxazines.

Liu XW, Wang C, Yan Y, Wang YQ, Sun J.

J Org Chem. 2013 Jun 21;78(12):6276-80. doi: 10.1021/jo400187e. Epub 2013 Jun 11.

PMID:
23718757
5.

Synthesis and biological activity of Akt/PI3K inhibitors.

Redaelli C, Granucci F, De Gioia L, Cipolla L.

Mini Rev Med Chem. 2006 Oct;6(10):1127-36. Review.

PMID:
17073713
6.

Development of pyridopyrimidines as potent Akt1/2 inhibitors.

Wu Z, Hartnett JC, Neilson LA, Robinson RG, Fu S, Barnett SF, Defeo-Jones D, Jones RE, Kral AM, Huber HE, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1274-9. doi: 10.1016/j.bmcl.2008.01.054. Epub 2008 Jan 19.

PMID:
18249537
7.

Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors.

Woods KW, Fischer JP, Claiborne A, Li T, Thomas SA, Zhu GD, Diebold RB, Liu X, Shi Y, Klinghofer V, Han EK, Guan R, Magnone SR, Johnson EF, Bouska JJ, Olson AM, de Jong R, Oltersdorf T, Luo Y, Rosenberg SH, Giranda VL, Li Q.

Bioorg Med Chem. 2006 Oct 15;14(20):6832-46. Epub 2006 Jul 14.

PMID:
16843670
8.

Structure-based de novo design and biochemical evaluation of novel BRAF kinase inhibitors.

Park H, Jeong Y, Hong S.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1027-30. doi: 10.1016/j.bmcl.2011.11.124. Epub 2011 Dec 7.

PMID:
22196123
9.

Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Substituted Amines.

Beisel T, Manolikakes G.

Org Lett. 2015 Jun 19;17(12):3162-5. doi: 10.1021/acs.orglett.5b01502. Epub 2015 Jun 8.

PMID:
26053313
10.

Enantioselective bromocycloetherification by Lewis base/chiral Brønsted acid cooperative catalysis.

Denmark SE, Burk MT.

Org Lett. 2012 Jan 6;14(1):256-9. doi: 10.1021/ol203033k. Epub 2011 Dec 6.

11.

Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt.

Ko JH, Yeon SW, Ryu JS, Kim TY, Song EH, You HJ, Park RE, Ryu CK.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):6001-5. Epub 2006 Sep 20.

PMID:
16990001
12.

Lewis base catalyzed enantioselective allylic hydroxylation of Morita-Baylis-Hillman carbonates with water.

Zhu B, Yan L, Pan Y, Lee R, Liu H, Han Z, Huang KW, Tan CH, Jiang Z.

J Org Chem. 2011 Aug 19;76(16):6894-900. doi: 10.1021/jo201096e. Epub 2011 Jul 22.

PMID:
21751799
13.

Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors.

Wu B, Wang HL, Cee VJ, Lanman BA, Nixey T, Pettus L, Reed AB, Wurz RP, Guerrero N, Sastri C, Winston J, Lipford JR, Lee MR, Mohr C, Andrews KL, Tasker AS.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):775-80. doi: 10.1016/j.bmcl.2014.12.091. Epub 2015 Jan 7.

PMID:
25616902
14.

Asymmetric synthesis of 4H-1,3-oxazines: enantioselective reductive cyclization of N-acylated beta-amino enones with trichlorosilane catalyzed by chiral Lewis bases.

Sugiura M, Kumahara M, Nakajima M.

Chem Commun (Camb). 2009 Jun 28;(24):3585-7. doi: 10.1039/b905102c. Epub 2009 May 11.

PMID:
19521616
15.

Highly diastereoselective and enantioselective synthesis of α-hydroxy β-amino acid derivatives: Lewis base catalyzed hydrosilylation of α-acetoxy β-enamino esters.

Jiang Y, Chen X, Zheng Y, Xue Z, Shu C, Yuan W, Zhang X.

Angew Chem Int Ed Engl. 2011 Aug 1;50(32):7304-7. doi: 10.1002/anie.201102150. Epub 2011 Jun 17. No abstract available.

PMID:
21688371
16.

Preparation and evaluation of deconstruction analogues of 7-deoxykalafungin as AKT kinase inhibitors.

Korwar S, Nguyen T, Ellis KC.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):271-4. doi: 10.1016/j.bmcl.2013.11.020. Epub 2013 Nov 20.

PMID:
24321345
17.

Discovery and SAR of spirochromane Akt inhibitors.

Kallan NC, Spencer KL, Blake JF, Xu R, Heizer J, Bencsik JR, Mitchell IS, Gloor SL, Martinson M, Risom T, Gross SD, Morales TH, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2410-4. doi: 10.1016/j.bmcl.2011.02.073. Epub 2011 Feb 18.

PMID:
21392984
18.

Enantioselective silyl protection of alcohols promoted by a combination of chiral and achiral Lewis basic catalysts.

Manville N, Alite H, Haeffner F, Hoveyda AH, Snapper ML.

Nat Chem. 2013 Sep;5(9):768-74. doi: 10.1038/nchem.1708. Epub 2013 Jul 28.

19.

Lewis base catalyzed, enantioselective, intramolecular sulfenoamination of olefins.

Denmark SE, Chi HM.

J Am Chem Soc. 2014 Jun 25;136(25):8915-8. doi: 10.1021/ja5046296. Epub 2014 Jun 13.

20.

Facile synthesis of planar chiral N-oxides and their use in Lewis base catalysis.

Fulton JR, Glover JE, Kamara L, Rowlands GJ.

Chem Commun (Camb). 2011 Jan 7;47(1):433-5. doi: 10.1039/c0cc02216k. Epub 2010 Sep 24.

PMID:
20865190
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