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Results: 1 to 20 of 106

1.

Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations.

Cembran A, Masterson LR, McClendon CL, Taylor SS, Gao J, Veglia G.

Biochemistry. 2012 Dec 21;51(51):10186-96. doi: 10.1021/bi301279f. Epub 2012 Dec 12.

PMID:
23205665
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A myristoyl/phosphoserine switch controls cAMP-dependent protein kinase association to membranes.

Gaffarogullari EC, Masterson LR, Metcalfe EE, Traaseth NJ, Balatri E, Musa MM, Mullen D, Distefano MD, Veglia G.

J Mol Biol. 2011 Aug 26;411(4):823-36. doi: 10.1016/j.jmb.2011.06.034. Epub 2011 Jun 29.

PMID:
21740913
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The typically disordered N-terminus of PKA can fold as a helix and project the myristoylation site into solution.

Breitenlechner C, Engh RA, Huber R, Kinzel V, Bossemeyer D, Gassel M.

Biochemistry. 2004 Jun 22;43(24):7743-9.

PMID:
15196017
[PubMed - indexed for MEDLINE]
4.

Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase.

Tholey A, Pipkorn R, Bossemeyer D, Kinzel V, Reed J.

Biochemistry. 2001 Jan 9;40(1):225-31.

PMID:
11141074
[PubMed - indexed for MEDLINE]
5.

Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution.

Preininger AM, Kaya AI, Gilbert JA 3rd, Busenlehner LS, Armstrong RN, Hamm HE.

Biochemistry. 2012 Mar 6;51(9):1911-24. doi: 10.1021/bi201472c. Epub 2012 Feb 22.

PMID:
22329346
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase.

Bastidas AC, Deal MS, Steichen JM, Keshwani MM, Guo Y, Taylor SS.

J Mol Biol. 2012 Sep 14;422(2):215-29. doi: 10.1016/j.jmb.2012.05.021. Epub 2012 May 19.

PMID:
22617327
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein.

Geyer M, Munte CE, Schorr J, Kellner R, Kalbitzer HR.

J Mol Biol. 1999 May 28;289(1):123-38.

PMID:
10339411
[PubMed - indexed for MEDLINE]
8.

Probing cAMP-dependent protein kinase holoenzyme complexes I alpha and II beta by FT-IR and chemical protein footprinting.

Yu S, Mei FC, Lee JC, Cheng X.

Biochemistry. 2004 Feb 24;43(7):1908-20.

PMID:
14967031
[PubMed - indexed for MEDLINE]
9.

Dynamics connect substrate recognition to catalysis in protein kinase A.

Masterson LR, Cheng C, Yu T, Tonelli M, Kornev A, Taylor SS, Veglia G.

Nat Chem Biol. 2010 Nov;6(11):821-8. doi: 10.1038/nchembio.452. Epub 2010 Oct 3. Erratum in: Nat Chem Biol. 2011 May;7(5):319.

PMID:
20890288
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Dynamic binding of PKA regulatory subunit RI alpha.

Gullingsrud J, Kim C, Taylor SS, McCammon JA.

Structure. 2006 Jan;14(1):141-9.

PMID:
16407073
[PubMed - indexed for MEDLINE]
Free Article
11.

Mapping substrate-induced conformational changes in cAMP-dependent protein kinase by protein footprinting.

Cheng X, Shaltiel S, Taylor SS.

Biochemistry. 1998 Oct 6;37(40):14005-13.

PMID:
9760235
[PubMed - indexed for MEDLINE]
12.

Alpha7 helix plays an important role in the conformational stability of PTP1B.

Olmez EO, Alakent B.

J Biomol Struct Dyn. 2011 Apr;28(5):675-93.

PMID:
21294582
[PubMed - indexed for MEDLINE]
13.

Influence of N-myristylation and ligand binding on the flexibility of the catalytic subunit of protein kinase A.

Bastidas AC, Pierce LC, Walker RC, Johnson DA, Taylor SS.

Biochemistry. 2013 Sep 17;52(37):6368-79. doi: 10.1021/bi400575k. Epub 2013 Sep 4.

PMID:
24003983
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA.

Kim C, Xuong NH, Taylor SS.

Science. 2005 Feb 4;307(5710):690-6.

PMID:
15692043
[PubMed - indexed for MEDLINE]
Free Article
15.

Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations.

Zheng J, Knighton DR, Xuong NH, Taylor SS, Sowadski JM, Ten Eyck LF.

Protein Sci. 1993 Oct;2(10):1559-73.

PMID:
8251932
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIalpha.

Abu-Abed M, Das R, Wang L, Melacini G.

Proteins. 2007 Oct 1;69(1):112-24.

PMID:
17596845
[PubMed - indexed for MEDLINE]
17.

Solution structure of synthetic peptide inhibitor and substrate of cAMP-dependent protein kinase. A study by 2D H NMR and molecular dynamics.

Padilla A, Hauer JA, Tsigelny I, Parello J, Taylor SS.

J Pept Res. 1997 Mar;49(3):210-20.

PMID:
9151254
[PubMed - indexed for MEDLINE]
18.

Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure.

Akamine P, Madhusudan, Wu J, Xuong NH, Ten Eyck LF, Taylor SS.

J Mol Biol. 2003 Mar 14;327(1):159-71.

PMID:
12614615
[PubMed - indexed for MEDLINE]
19.

Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit.

Akamine P, Madhusudan, Brunton LL, Ou HD, Canaves JM, Xuong NH, Taylor SS.

Biochemistry. 2004 Jan 13;43(1):85-96.

PMID:
14705934
[PubMed - indexed for MEDLINE]
20.

Impact of N-terminal myristoylation on the Ca2+-dependent conformational transition in recoverin.

Weiergräber OH, Senin II, Philippov PP, Granzin J, Koch KW.

J Biol Chem. 2003 Jun 20;278(25):22972-9. Epub 2003 Apr 9.

PMID:
12686556
[PubMed - indexed for MEDLINE]
Free Article

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