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Results: 1 to 20 of 187

1.

Pathogenic cellular phenotypes are germline transmissible in a transgenic primate model of Huntington's disease.

Putkhao K, Kocerha J, Cho IK, Yang J, Parnpai R, Chan AW.

Stem Cells Dev. 2013 Apr 15;22(8):1198-205. doi: 10.1089/scd.2012.0469. Epub 2013 Jan 15.

PMID:
23190281
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Towards a transgenic model of Huntington's disease in a non-human primate.

Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH, Li XJ, Chan AW.

Nature. 2008 Jun 12;453(7197):921-4. doi: 10.1038/nature06975. Epub 2008 May 18.

PMID:
18488016
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein.

Cheng PH, Li CL, Her LS, Chang YF, Chan AW, Chen CM, Yang SH.

Brain Struct Funct. 2013 Jan;218(1):283-94. doi: 10.1007/s00429-012-0401-x. Epub 2012 Mar 16.

PMID:
22422149
[PubMed - indexed for MEDLINE]
4.

Reprogramming Huntington monkey skin cells into pluripotent stem cells.

Chan AW, Cheng PH, Neumann A, Yang JJ.

Cell Reprogram. 2010 Oct;12(5):509-17. doi: 10.1089/cell.2010.0019.

PMID:
20936902
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.

Bradford J, Shin JY, Roberts M, Wang CE, Sheng G, Li S, Li XJ.

J Biol Chem. 2010 Apr 2;285(14):10653-61. doi: 10.1074/jbc.M109.083287. Epub 2010 Feb 9.

PMID:
20145253
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.

Reddy PH, Charles V, Williams M, Miller G, Whetsell WO Jr, Tagle DA.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1035-45.

PMID:
10434303
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A two years longitudinal study of a transgenic Huntington disease monkey.

Chan AW, Xu Y, Jiang J, Rahim T, Zhao D, Kocerha J, Chi T, Moran S, Engelhardt H, Larkin K, Neumann A, Cheng H, Li C, Nelson K, Banta H, Zola SM, Villinger F, Yang J, Testa CM, Mao H, Zhang X, Bachevalier J.

BMC Neurosci. 2014 Mar 3;15:36. doi: 10.1186/1471-2202-15-36.

PMID:
24581271
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.

Lloret A, Dragileva E, Teed A, Espinola J, Fossale E, Gillis T, Lopez E, Myers RH, MacDonald ME, Wheeler VC.

Hum Mol Genet. 2006 Jun 15;15(12):2015-24. Epub 2006 May 10.

PMID:
16687439
[PubMed - indexed for MEDLINE]
Free Article
10.

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.

Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM.

Neurobiol Dis. 2006 Feb;21(2):381-91. Epub 2005 Sep 16.

PMID:
16150600
[PubMed - indexed for MEDLINE]
11.

Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice.

Garriga-Canut M, Agustín-Pavón C, Herrmann F, Sánchez A, Dierssen M, Fillat C, Isalan M.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):E3136-45. doi: 10.1073/pnas.1206506109. Epub 2012 Oct 10.

PMID:
23054839
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

Wang H, Lim PJ, Karbowski M, Monteiro MJ.

Hum Mol Genet. 2009 Feb 15;18(4):737-52. doi: 10.1093/hmg/ddn404. Epub 2008 Nov 27.

PMID:
19039036
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Derivation of Huntington's disease-affected human embryonic stem cell lines.

Bradley CK, Scott HA, Chami O, Peura TT, Dumevska B, Schmidt U, Stojanov T.

Stem Cells Dev. 2011 Mar;20(3):495-502. doi: 10.1089/scd.2010.0120. Epub 2010 Aug 31.

PMID:
20649476
[PubMed - indexed for MEDLINE]
14.

Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain.

Liu W, Chaurette J, Pfister EL, Kennington LA, Chase KO, Bullock J, Vonsattel JP, Faull RL, Macdonald D, DiFiglia M, Zamore PD, Aronin N.

J Huntingtons Dis. 2013;2(4):491-500. doi: 10.3233/JHD-130079.

PMID:
25062733
[PubMed - indexed for MEDLINE]
15.

Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.

Kovalenko M, Dragileva E, St Claire J, Gillis T, Guide JR, New J, Dong H, Kucherlapati R, Kucherlapati MH, Ehrlich ME, Lee JM, Wheeler VC.

PLoS One. 2012;7(9):e44273. doi: 10.1371/journal.pone.0044273. Epub 2012 Sep 7.

PMID:
22970194
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity.

Bañez-Coronel M, Porta S, Kagerbauer B, Mateu-Huertas E, Pantano L, Ferrer I, Guzmán M, Estivill X, Martí E.

PLoS Genet. 2012;8(2):e1002481. doi: 10.1371/journal.pgen.1002481. Epub 2012 Feb 23.

PMID:
22383888
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.

Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimäki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM.

J Neurosci. 2012 May 30;32(22):7454-65. doi: 10.1523/JNEUROSCI.6379-11.2012.

PMID:
22649225
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Transgenic rat model of Huntington's disease.

von Hörsten S, Schmitt I, Nguyen HP, Holzmann C, Schmidt T, Walther T, Bader M, Pabst R, Kobbe P, Krotova J, Stiller D, Kask A, Vaarmann A, Rathke-Hartlieb S, Schulz JB, Grasshoff U, Bauer I, Vieira-Saecker AM, Paul M, Jones L, Lindenberg KS, Landwehrmeyer B, Bauer A, Li XJ, Riess O.

Hum Mol Genet. 2003 Mar 15;12(6):617-24.

PMID:
12620967
[PubMed - indexed for MEDLINE]
Free Article
19.

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.

Chan EY, Luthi-Carter R, Strand A, Solano SM, Hanson SA, DeJohn MM, Kooperberg C, Chase KO, DiFiglia M, Young AB, Leavitt BR, Cha JH, Aronin N, Hayden MR, Olson JM.

Hum Mol Genet. 2002 Aug 15;11(17):1939-51.

PMID:
12165556
[PubMed - indexed for MEDLINE]
Free Article
20.

Multiple phenotypes in Huntington disease mouse neural stem cells.

Ritch JJ, Valencia A, Alexander J, Sapp E, Gatune L, Sangrey GR, Sinha S, Scherber CM, Zeitlin S, Sadri-Vakili G, Irimia D, Difiglia M, Kegel KB.

Mol Cell Neurosci. 2012 May;50(1):70-81. doi: 10.1016/j.mcn.2012.03.011. Epub 2012 Apr 6.

PMID:
22508027
[PubMed - indexed for MEDLINE]
Free PMC Article

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