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Results: 1 to 20 of 74

Similar articles for PubMed (Select 23188502)

1.

Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.

Proffitt KD, Madan B, Ke Z, Pendharkar V, Ding L, Lee MA, Hannoush RN, Virshup DM.

Cancer Res. 2013 Jan 15;73(2):502-7. doi: 10.1158/0008-5472.CAN-12-2258. Epub 2012 Nov 27.

2.

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.

Liu J, Pan S, Hsieh MH, Ng N, Sun F, Wang T, Kasibhatla S, Schuller AG, Li AG, Cheng D, Li J, Tompkins C, Pferdekamper A, Steffy A, Cheng J, Kowal C, Phung V, Guo G, Wang Y, Graham MP, Flynn S, Brenner JC, Li C, Villarroel MC, Schultz PG, Wu X, McNamara P, Sellers WR, Petruzzelli L, Boral AL, Seidel HM, McLaughlin ME, Che J, Carey TE, Vanasse G, Harris JL.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9. doi: 10.1073/pnas.1314239110. Epub 2013 Nov 25.

3.

PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.

Covey TM, Kaur S, Tan Ong T, Proffitt KD, Wu Y, Tan P, Virshup DM.

PLoS One. 2012;7(4):e34532. doi: 10.1371/journal.pone.0034532. Epub 2012 Apr 11.

4.

Precise regulation of porcupine activity is required for physiological Wnt signaling.

Proffitt KD, Virshup DM.

J Biol Chem. 2012 Oct 5;287(41):34167-78. doi: 10.1074/jbc.M112.381970. Epub 2012 Aug 10.

5.

Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome.

Barrott JJ, Cash GM, Smith AP, Barrow JR, Murtaugh LC.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12752-7. doi: 10.1073/pnas.1006437108. Epub 2011 Jul 18.

6.

Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment.

Cheng Y, Phoon YP, Jin X, Chong SY, Ip JC, Wong BW, Lung ML.

Oncotarget. 2015 Jun 10;6(16):14428-39.

7.

Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells.

Kabiri Z, Numata A, Kawasaki A, Blank E, Tenen DG, Virshup DM.

Blood. 2015 Jun 18. pii: blood-2014-09-598540. [Epub ahead of print]

PMID:
26089398
8.

A Wnt-ow of opportunity: targeting the Wnt/beta-catenin pathway in breast cancer.

Prosperi JR, Goss KH.

Curr Drug Targets. 2010 Sep;11(9):1074-88. Review.

PMID:
20545611
9.

Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos.

Biechele S, Cox BJ, Rossant J.

Dev Biol. 2011 Jul 15;355(2):275-85. doi: 10.1016/j.ydbio.2011.04.029. Epub 2011 Apr 30.

10.

Porcn-dependent Wnt signaling is not required prior to mouse gastrulation.

Biechele S, Cockburn K, Lanner F, Cox BJ, Rossant J.

Development. 2013 Jul;140(14):2961-71. doi: 10.1242/dev.094458. Epub 2013 Jun 12.

11.

A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities.

Najdi R, Proffitt K, Sprowl S, Kaur S, Yu J, Covey TM, Virshup DM, Waterman ML.

Differentiation. 2012 Sep;84(2):203-13. doi: 10.1016/j.diff.2012.06.004. Epub 2012 Jul 9.

12.

Discovery and Optimization of a Porcupine Inhibitor.

Duraiswamy AJ, Lee MA, Madan B, Ang SH, Tan ES, Cheong WW, Ke Z, Pendharkar V, Ding LJ, Chew YS, Manoharan V, Sangthongpitag K, Alam J, Poulsen A, Ho SY, Virshup DM, Keller TH.

J Med Chem. 2015 Aug 13;58(15):5889-99. doi: 10.1021/acs.jmedchem.5b00507. Epub 2015 Jul 16.

PMID:
26110200
13.

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.

Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L.

J Biol Chem. 2012 Jun 29;287(27):23246-54. doi: 10.1074/jbc.M112.372029. Epub 2012 May 15.

14.

The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers.

Rieger ME, Sims AH, Coats ER, Clarke RB, Briegel KJ.

Mol Cell Biol. 2010 Sep;30(17):4267-79. doi: 10.1128/MCB.01418-09. Epub 2010 Jul 6.

15.

Porcupine-mediated lipidation is required for Wnt recognition by Wls.

Herr P, Basler K.

Dev Biol. 2012 Jan 15;361(2):392-402. doi: 10.1016/j.ydbio.2011.11.003. Epub 2011 Nov 11.

16.

Identification of key residues and regions important for porcupine-mediated Wnt acylation.

Rios-Esteves J, Haugen B, Resh MD.

J Biol Chem. 2014 Jun 13;289(24):17009-19. doi: 10.1074/jbc.M114.561209. Epub 2014 May 5.

17.

Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades.

Katoh M, Katoh M.

Cancer Biol Ther. 2006 Sep;5(9):1059-64. Epub 2006 Sep 4. Review.

PMID:
16940750
18.

ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas.

Schroeder JA, Adriance MC, McConnell EJ, Thompson MC, Pockaj B, Gendler SJ.

J Biol Chem. 2002 Jun 21;277(25):22692-8. Epub 2002 Apr 11.

19.
20.

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.

Ettenberg SA, Charlat O, Daley MP, Liu S, Vincent KJ, Stuart DD, Schuller AG, Yuan J, Ospina B, Green J, Yu Q, Walsh R, Li S, Schmitz R, Heine H, Bilic S, Ostrom L, Mosher R, Hartlepp KF, Zhu Z, Fawell S, Yao YM, Stover D, Finan PM, Porter JA, Sellers WR, Klagge IM, Cong F.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15473-8. doi: 10.1073/pnas.1007428107. Epub 2010 Aug 16.

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