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Results: 1 to 20 of 142

1.

A molecular mechanism for direct sirtuin activation by resveratrol.

Gertz M, Nguyen GT, Fischer F, Suenkel B, Schlicker C, Fränzel B, Tomaschewski J, Aladini F, Becker C, Wolters D, Steegborn C.

PLoS One. 2012;7(11):e49761. doi: 10.1371/journal.pone.0049761. Epub 2012 Nov 21.

PMID:
23185430
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Mechanism of human SIRT1 activation by resveratrol.

Borra MT, Smith BC, Denu JM.

J Biol Chem. 2005 Apr 29;280(17):17187-95. Epub 2005 Mar 4.

PMID:
15749705
[PubMed - indexed for MEDLINE]
Free Article
3.

Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.

Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker CF, Steegborn C.

J Mol Biol. 2008 Oct 10;382(3):790-801. doi: 10.1016/j.jmb.2008.07.048. Epub 2008 Jul 25.

PMID:
18680753
[PubMed - indexed for MEDLINE]
4.

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K.

J Biol Chem. 2010 Mar 12;285(11):8340-51. doi: 10.1074/jbc.M109.088682. Epub 2010 Jan 8.

PMID:
20061378
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Crystal structures of sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism.

Nguyen GT, Gertz M, Steegborn C.

Chem Biol. 2013 Nov 21;20(11):1375-85. doi: 10.1016/j.chembiol.2013.09.019. Epub 2013 Nov 7.

PMID:
24211137
[PubMed - in process]
6.

Substrate-specific activation of sirtuins by resveratrol.

Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK.

J Biol Chem. 2005 Apr 29;280(17):17038-45. Epub 2005 Jan 31.

PMID:
15684413
[PubMed - indexed for MEDLINE]
Free Article
7.

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.

Nature. 2003 Sep 11;425(6954):191-6. Epub 2003 Aug 24.

PMID:
12939617
[PubMed - indexed for MEDLINE]
8.

Synthesis of carba-NAD and the structures of its ternary complexes with SIRT3 and SIRT5.

Szczepankiewicz BG, Dai H, Koppetsch KJ, Qian D, Jiang F, Mao C, Perni RB.

J Org Chem. 2012 Sep 7;77(17):7319-29. doi: 10.1021/jo301067e. Epub 2012 Aug 17.

PMID:
22849721
[PubMed - indexed for MEDLINE]
9.

Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism.

Nguyen GT, Schaefer S, Gertz M, Weyand M, Steegborn C.

Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1423-32. doi: 10.1107/S0907444913015448. Epub 2013 Jul 17.

PMID:
23897466
[PubMed - indexed for MEDLINE]
10.

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.

Rauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F, Kambach C, Becker CF, Zerweck J, Schutkowski M, Steegborn C.

Nat Commun. 2013;4:2327. doi: 10.1038/ncomms3327.

PMID:
23995836
[PubMed - indexed for MEDLINE]
11.

Sirt1 activation by resveratrol is substrate sequence-selective.

Lakshminarasimhan M, Rauh D, Schutkowski M, Steegborn C.

Aging (Albany NY). 2013 Mar;5(3):151-4.

PMID:
23524286
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.

Lakshminarasimhan M, Curth U, Moniot S, Mosalaganti S, Raunser S, Steegborn C.

Biosci Rep. 2013 May 15;33(3). pii: e00037. doi: 10.1042/BSR20120121.

PMID:
23548308
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Crystal structures of human SIRT3 displaying substrate-induced conformational changes.

Jin L, Wei W, Jiang Y, Peng H, Cai J, Mao C, Dai H, Choy W, Bemis JE, Jirousek MR, Milne JC, Westphal CH, Perni RB.

J Biol Chem. 2009 Sep 4;284(36):24394-405. doi: 10.1074/jbc.M109.014928. Epub 2009 Jun 16.

PMID:
19535340
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Sirtuin activators.

Alcaín FJ, Villalba JM.

Expert Opin Ther Pat. 2009 Apr;19(4):403-14. doi: 10.1517/13543770902762893. Review.

PMID:
19441923
[PubMed - indexed for MEDLINE]
15.

Resveratrol is not a direct activator of SIRT1 enzyme activity.

Beher D, Wu J, Cumine S, Kim KW, Lu SC, Atangan L, Wang M.

Chem Biol Drug Des. 2009 Dec;74(6):619-24. doi: 10.1111/j.1747-0285.2009.00901.x. Epub 2009 Oct 20.

PMID:
19843076
[PubMed - indexed for MEDLINE]
16.

Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.

Gertz M, Steegborn C.

Biochim Biophys Acta. 2010 Aug;1804(8):1658-65. doi: 10.1016/j.bbapap.2009.09.011. Epub 2009 Sep 18. Review.

PMID:
19766741
[PubMed - indexed for MEDLINE]
Free Article
17.

SIRT3 substrate specificity determined by peptide arrays and machine learning.

Smith BC, Settles B, Hallows WC, Craven MW, Denu JM.

ACS Chem Biol. 2011 Feb 18;6(2):146-57. doi: 10.1021/cb100218d. Epub 2010 Nov 1.

PMID:
20945913
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.

Kitada M, Kume S, Takeda-Watanabe A, Kanasaki K, Koya D.

Clin Sci (Lond). 2013 Feb;124(3):153-64. doi: 10.1042/CS20120190. Review.

PMID:
23075334
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.

Feldman JL, Baeza J, Denu JM.

J Biol Chem. 2013 Oct 25;288(43):31350-6. doi: 10.1074/jbc.C113.511261. Epub 2013 Sep 18.

PMID:
24052263
[PubMed - indexed for MEDLINE]
20.

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism.

Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH.

Physiol Rev. 2012 Jul;92(3):1479-514. doi: 10.1152/physrev.00022.2011. Review.

PMID:
22811431
[PubMed - indexed for MEDLINE]
Free PMC Article

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