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Results: 1 to 20 of 129

1.

Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo.

Wong SC, Klein JJ, Hamilton HL, Chu Q, Frey CL, Trubetskoy VS, Hegge J, Wakefield D, Rozema DB, Lewis DL.

Nucleic Acid Ther. 2012 Dec;22(6):380-90. doi: 10.1089/nat.2012.0389.

PMID:
23181701
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection.

Wooddell CI, Rozema DB, Hossbach M, John M, Hamilton HL, Chu Q, Hegge JO, Klein JJ, Wakefield DH, Oropeza CE, Deckert J, Roehl I, Jahn-Hofmann K, Hadwiger P, Vornlocher HP, McLachlan A, Lewis DL.

Mol Ther. 2013 May;21(5):973-85. doi: 10.1038/mt.2013.31. Epub 2013 Feb 26.

PMID:
23439496
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes.

Rozema DB, Lewis DL, Wakefield DH, Wong SC, Klein JJ, Roesch PL, Bertin SL, Reppen TW, Chu Q, Blokhin AV, Hagstrom JE, Wolff JA.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):12982-7. Epub 2007 Jul 24.

PMID:
17652171
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

A biomimetic nanovector-mediated targeted cholesterol-conjugated siRNA delivery for tumor gene therapy.

Ding Y, Wang W, Feng M, Wang Y, Zhou J, Ding X, Zhou X, Liu C, Wang R, Zhang Q.

Biomaterials. 2012 Dec;33(34):8893-905. doi: 10.1016/j.biomaterials.2012.08.057. Epub 2012 Sep 12.

PMID:
22979990
[PubMed - indexed for MEDLINE]
5.

N-acetylgalactosamine functionalized mixed micellar nanoparticles for targeted delivery of siRNA to liver.

Wang HX, Xiong MH, Wang YC, Zhu J, Wang J.

J Control Release. 2013 Mar 10;166(2):106-14. doi: 10.1016/j.jconrel.2012.12.017. Epub 2012 Dec 20.

PMID:
23266452
[PubMed - indexed for MEDLINE]
6.

siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids.

Tadin-Strapps M, Peterson LB, Cumiskey AM, Rosa RL, Mendoza VH, Castro-Perez J, Puig O, Zhang L, Strapps WR, Yendluri S, Andrews L, Pickering V, Rice J, Luo L, Chen Z, Tep S, Ason B, Somers EP, Sachs AB, Bartz SR, Tian J, Chin J, Hubbard BK, Wong KK, Mitnaul LJ.

J Lipid Res. 2011 Jun;52(6):1084-97. doi: 10.1194/jlr.M012872. Epub 2011 Mar 11.

PMID:
21398511
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Lipid-like materials for low-dose, in vivo gene silencing.

Love KT, Mahon KP, Levins CG, Whitehead KA, Querbes W, Dorkin JR, Qin J, Cantley W, Qin LL, Racie T, Frank-Kamenetsky M, Yip KN, Alvarez R, Sah DW, de Fougerolles A, Fitzgerald K, Koteliansky V, Akinc A, Langer R, Anderson DG.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1864-9. doi: 10.1073/pnas.0910603106. Epub 2010 Jan 11. Erratum in: Proc Natl Acad Sci U S A. 2010 May 25;107(21):9915.

PMID:
20080679
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Development of lipidoid-siRNA formulations for systemic delivery to the liver.

Akinc A, Goldberg M, Qin J, Dorkin JR, Gamba-Vitalo C, Maier M, Jayaprakash KN, Jayaraman M, Rajeev KG, Manoharan M, Koteliansky V, Röhl I, Leshchiner ES, Langer R, Anderson DG.

Mol Ther. 2009 May;17(5):872-9. doi: 10.1038/mt.2009.36. Epub 2009 Mar 3.

PMID:
19259063
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Efficient reduction of serum cholesterol by combining a liver-targeted gene delivery system with chemically modified apolipoprotein B siRNA.

Kang JH, Tachibana Y, Obika S, Harada-Shiba M, Yamaoka T.

J Control Release. 2012 Oct 28;163(2):119-24. doi: 10.1016/j.jconrel.2012.08.030. Epub 2012 Sep 4.

PMID:
22974833
[PubMed - indexed for MEDLINE]
10.

Endosomolytic bioreducible poly(amido amine disulfide) polymer conjugates for the in vivo systemic delivery of siRNA therapeutics.

Parmar RG, Busuek M, Walsh ES, Leander KR, Howell BJ, Sepp-Lorenzino L, Kemp E, Crocker LS, Leone A, Kochansky CJ, Carr BA, Garbaccio RM, Colletti SL, Wang W.

Bioconjug Chem. 2013 Apr 17;24(4):640-7. doi: 10.1021/bc300600a. Epub 2013 Mar 25.

PMID:
23496378
[PubMed - indexed for MEDLINE]
11.

Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoprotein.

Kuwahara H, Nishina K, Yoshida K, Nishina T, Yamamoto M, Saito Y, Piao W, Yoshida M, Mizusawa H, Yokota T.

Mol Ther. 2011 Dec;19(12):2213-21. doi: 10.1038/mt.2011.186. Epub 2011 Sep 13.

PMID:
21915100
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

Wolfrum C, Shi S, Jayaprakash KN, Jayaraman M, Wang G, Pandey RK, Rajeev KG, Nakayama T, Charrise K, Ndungo EM, Zimmermann T, Koteliansky V, Manoharan M, Stoffel M.

Nat Biotechnol. 2007 Oct;25(10):1149-57. Epub 2007 Sep 16.

PMID:
17873866
[PubMed - indexed for MEDLINE]
13.

Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.

Safdar H, Cheung KL, Vos HL, Gonzalez FJ, Reitsma PH, Inoue Y, van Vlijmen BJ.

PLoS One. 2012;7(6):e38104. doi: 10.1371/journal.pone.0038104. Epub 2012 Jun 1.

PMID:
22675511
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Efficient systemic delivery of siRNA to the mouse liver by pegylated lipopolymer.

Liu J, Van S, Ma N, Yu L.

Int J Pharm. 2012 May 1;427(1):58-63. doi: 10.1016/j.ijpharm.2011.11.006. Epub 2011 Nov 11.

PMID:
22100515
[PubMed - indexed for MEDLINE]
15.

Galactose-modified cationic liposomes as a liver-targeting delivery system for small interfering RNA.

Sonoke S, Ueda T, Fujiwara K, Kuwabara K, Yano J.

Biol Pharm Bull. 2011;34(8):1338-42.

PMID:
21804229
[PubMed - indexed for MEDLINE]
Free Article
16.

A novel in vivo siRNA delivery system specifically targeting liver cells for protection of ConA-induced fulminant hepatitis.

Jiang N, Zhang X, Zheng X, Chen D, Siu K, Wang H, Ichim TE, Quan D, McAlister V, Chen G, Min WP.

PLoS One. 2012;7(9):e44138. doi: 10.1371/journal.pone.0044138. Epub 2012 Sep 6.

PMID:
22970170
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes.

Malek A, Merkel O, Fink L, Czubayko F, Kissel T, Aigner A.

Toxicol Appl Pharmacol. 2009 Apr 1;236(1):97-108. doi: 10.1016/j.taap.2009.01.014. Epub 2009 Jan 29.

PMID:
19371615
[PubMed - indexed for MEDLINE]
18.

Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol.

Nishina K, Unno T, Uno Y, Kubodera T, Kanouchi T, Mizusawa H, Yokota T.

Mol Ther. 2008 Apr;16(4):734-40. doi: 10.1038/mt.2008.14. Epub 2008 Feb 12.

PMID:
18362929
[PubMed - indexed for MEDLINE]
19.

CD40 gene silencing reduces the progression of experimental lupus nephritis modulating local milieu and systemic mechanisms.

Ripoll È, Merino A, Herrero-Fresneda I, Aran JM, Goma M, Bolaños N, de Ramon L, Bestard O, Cruzado JM, Grinyó JM, Torras J.

PLoS One. 2013 Jun 14;8(6):e65068. doi: 10.1371/journal.pone.0065068. Print 2013. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/8494360d-8ab1-4575-8a01-fb288ffde976.

PMID:
23799000
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.

Akinc A, Querbes W, De S, Qin J, Frank-Kamenetsky M, Jayaprakash KN, Jayaraman M, Rajeev KG, Cantley WL, Dorkin JR, Butler JS, Qin L, Racie T, Sprague A, Fava E, Zeigerer A, Hope MJ, Zerial M, Sah DW, Fitzgerald K, Tracy MA, Manoharan M, Koteliansky V, Fougerolles Ad, Maier MA.

Mol Ther. 2010 Jul;18(7):1357-64. doi: 10.1038/mt.2010.85. Epub 2010 May 11.

PMID:
20461061
[PubMed - indexed for MEDLINE]
Free PMC Article

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