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Results: 1 to 20 of 146

1.

Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation.

Diao X, Deng P, Xie C, Li X, Zhong D, Zhang Y, Chen X.

Drug Metab Dispos. 2013 Feb;41(2):430-44. doi: 10.1124/dmd.112.049684. Epub 2012 Nov 20.

PMID:
23169608
[PubMed - indexed for MEDLINE]
Free Article
3.

Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC-MS/MS using deuterated internal standards.

Diao X, Ma Z, Wang H, Zhong D, Zhang Y, Jin J, Fan Y, Chen X.

J Pharm Biomed Anal. 2013 May 5;78-79:19-26. doi: 10.1016/j.jpba.2013.01.033. Epub 2013 Feb 1.

PMID:
23434525
[PubMed - indexed for MEDLINE]
4.

In vitro studies on the oxidative metabolism of 20(s)-ginsenoside Rh2 in human, monkey, dog, rat, and mouse liver microsomes, and human liver s9.

Li L, Chen X, Zhou J, Zhong D.

Drug Metab Dispos. 2012 Oct;40(10):2041-53. doi: 10.1124/dmd.112.046995. Epub 2012 Jul 24.

PMID:
22829543
[PubMed - indexed for MEDLINE]
Free Article
5.

Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist.

Ghosal A, Ramanathan R, Yuan Y, Hapangama N, Chowdhury SK, Kishnani NS, Alton KB.

Drug Metab Dispos. 2007 Dec;35(12):2186-95. Epub 2007 Sep 7.

PMID:
17827338
[PubMed - indexed for MEDLINE]
Free Article
6.

Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.

Yao HT, Wu YS, Chang YW, Hsieh HP, Chen WC, Lan SJ, Chen CT, Chao YS, Chang L, Sun HY, Yeh TK.

Drug Metab Dispos. 2007 Jul;35(7):1042-9. Epub 2007 Apr 2.

PMID:
17403915
[PubMed - indexed for MEDLINE]
Free Article
7.

Novel metabolites of buprenorphine detected in human liver microsomes and human urine.

Chang Y, Moody DE, McCance-Katz EF.

Drug Metab Dispos. 2006 Mar;34(3):440-8. Epub 2005 Dec 28.

PMID:
16381669
[PubMed - indexed for MEDLINE]
Free Article
8.

Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.

Patten CJ, Smith TJ, Murphy SE, Wang MH, Lee J, Tynes RE, Koch P, Yang CS.

Arch Biochem Biophys. 1996 Sep 1;333(1):127-38.

PMID:
8806763
[PubMed - indexed for MEDLINE]
9.

Characterization of the metabolism of sibiricaxanthone F and its aglycone in vitro by high performance liquid chromatography coupled with Q-trap mass spectrometry.

Song Y, Yang X, Jiang Y, Tu P.

J Pharm Biomed Anal. 2012 Nov;70:700-7. doi: 10.1016/j.jpba.2012.06.038. Epub 2012 Jul 3.

PMID:
22819207
[PubMed - indexed for MEDLINE]
10.

In vitro biotransformation and investigation of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken, and pigs.

Liu ZY, Chen DM, Huang LL, Tao YF, Yao M, Yuan ZH.

Toxicology. 2011 Jan 11;279(1-3):155-66. doi: 10.1016/j.tox.2010.10.005. Epub 2010 Oct 16.

PMID:
20955753
[PubMed - indexed for MEDLINE]
11.

Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro.

Bakken GV, Molden E, Knutsen K, Lunder N, Hermann M.

Drug Metab Dispos. 2012 Sep;40(9):1778-84. doi: 10.1124/dmd.112.045237. Epub 2012 Jun 11.

PMID:
22688609
[PubMed - indexed for MEDLINE]
Free Article
12.

In vitro and in vivo metabolism of a gamma-secretase inhibitor BMS-299897 and generation of active metabolites in milligram quantities with a microbial bioreactor.

Zhang D, Hanson R, Roongta V, Dischino DD, Gao Q, Sloan CP, Polson C, Keavy D, Zheng M, Mitroka J, Yeola S.

Curr Drug Metab. 2006 Dec;7(8):883-96.

PMID:
17168689
[PubMed - indexed for MEDLINE]
13.

Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys.

Tan EY, Hartmann G, Chen Q, Pereira A, Bradley S, Doss G, Zhang AS, Ho JZ, Braun MP, Dean DC, Tang W, Kumar S.

Drug Metab Dispos. 2010 Mar;38(3):459-73. doi: 10.1124/dmd.109.028696. Epub 2009 Dec 16.

PMID:
20016052
[PubMed - indexed for MEDLINE]
Free Article
14.

Excretion, metabolism, and pharmacokinetics of 1-(8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl)-4-(ethylamino)piperidine-4-carboxamide, a selective cannabinoid receptor antagonist, in healthy male volunteers.

Miao Z, Sun H, Liras J, Prakash C.

Drug Metab Dispos. 2012 Mar;40(3):568-78. doi: 10.1124/dmd.111.043273. Epub 2011 Dec 20.

PMID:
22187487
[PubMed - indexed for MEDLINE]
Free Article
15.

Characterization of cytochrome P450s mediating ipriflavone metabolism in human liver microsomes.

Moon Y, Kim SY, Ji HY, Kim YK, Chae HJ, Chae SW, Lee HS.

Xenobiotica. 2007 Mar;37(3):246-59.

PMID:
17624023
[PubMed - indexed for MEDLINE]
16.

Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients.

Xie C, Zhou J, Guo Z, Diao X, Gao Z, Zhong D, Jiang H, Zhang L, Chen X.

Br J Pharmacol. 2013 Apr;168(7):1687-706. doi: 10.1111/bph.12047.

PMID:
23126373
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.

Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.

Biopharm Drug Dispos. 2006 Nov;27(8):371-86.

PMID:
16944451
[PubMed - indexed for MEDLINE]
18.

Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans.

Vincent SH, Reed JR, Bergman AJ, Elmore CS, Zhu B, Xu S, Ebel D, Larson P, Zeng W, Chen L, Dilzer S, Lasseter K, Gottesdiener K, Wagner JA, Herman GA.

Drug Metab Dispos. 2007 Apr;35(4):533-8. Epub 2007 Jan 12.

PMID:
17220239
[PubMed - indexed for MEDLINE]
Free Article
19.
20.

CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide.

Bidstrup TB, Bjørnsdottir I, Sidelmann UG, Thomsen MS, Hansen KT.

Br J Clin Pharmacol. 2003 Sep;56(3):305-14.

PMID:
12919179
[PubMed - indexed for MEDLINE]
Free PMC Article

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