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Results: 1 to 20 of 99

1.

Probes for narcotic receptor mediated phenomena. 46. N-substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols - carbocyclic relatives of f-oxide-bridged phenylmorphans.

Li F, Deck JA, Dersch CM, Rothman RB, Deschamps JR, Jacobson AE, Rice KC.

Eur J Med Chem. 2012 Dec;58:557-67. doi: 10.1016/j.ejmech.2012.10.041. Epub 2012 Oct 30.

PMID:
23168379
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Probes for narcotic receptor mediated phenomena. Part 42: synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans.

Kim JH, Deschamps JR, Rothman RB, Dersch CM, Folk JE, Cheng K, Jacobson AE, Rice KC.

Bioorg Med Chem. 2011 Jun 1;19(11):3434-43. doi: 10.1016/j.bmc.2011.04.028. Epub 2011 Apr 22.

PMID:
21570305
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Probes for narcotic receptor mediated phenomena. 43. Synthesis of the ortho-a and para-a, and improved synthesis and optical resolution of the ortho-b and para-b oxide-bridged phenylmorphans: compounds with moderate to low opioid-receptor affinity.

Li F, Folk JE, Cheng K, Kurimura M, Deck JA, Deschamps JR, Rothman RB, Dersch CM, Jacobson AE, Rice KC.

Bioorg Med Chem. 2011 Jul 15;19(14):4330-7. doi: 10.1016/j.bmc.2011.05.035. Epub 2011 May 24.

PMID:
21684752
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Synthesis and pharmacological effects of the enantiomers of the N-phenethyl analogues of the ortho and para e- and f-oxide-bridged phenylmorphans.

Zezula J, Singer L, Przybył AK, Hashimoto A, Dersch CM, Rothman RB, Deschamps J, Lee YS, Jacobson AE, Rice KC.

Org Biomol Chem. 2008 Aug 21;6(16):2868-83. doi: 10.1039/b803433h. Epub 2008 Jun 13.

PMID:
18688479
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Probes for narcotic receptor mediated phenomena. 37. Synthesis and opioid binding affinity of the final pair of oxide-bridged phenylmorphans, the ortho- and para-b-isomers and their N-phenethyl analogues, and the synthesis of the N-phenethyl analogues of the ortho- and para-d-isomers.

Kurimura M, Liu H, Sulima A, Hashimoto A, Przybyl AK, Ohshima E, Kodato S, Deschamps JR, Dersch CM, Rothman RB, Lee YS, Jacobson AE, Rice KC.

J Med Chem. 2008 Dec 25;51(24):7866-81. doi: 10.1021/jm800913d. Erratum in: J Med Chem. 2009 Feb 26;52(4):1229.

PMID:
19053757
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Probes for narcotic receptor mediated phenomena. 39. Enantiomeric N-substituted benzofuro[2,3-c]pyridin-6-ols: synthesis and topological relationship to oxide-bridged phenylmorphans.

Zhang Y, Lee YS, Rothman RB, Dersch CM, Deschamps JR, Jacobson AE, Rice KC.

J Med Chem. 2009 Dec 10;52(23):7570-9. doi: 10.1021/jm9004225.

PMID:
19627147
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Probes for narcotic receptor mediated phenomena. 48. C7- and C8-substituted 5-phenylmorphan opioids from diastereoselective alkylation.

Lim HJ, Dersch CM, Rothman RB, Deschamps JR, Jacobson AE, Rice KC.

Eur J Med Chem. 2013 Sep;67:335-43. doi: 10.1016/j.ejmech.2013.06.030. Epub 2013 Jun 25.

PMID:
23880358
[PubMed - indexed for MEDLINE]
8.

Probes for narcotic receptor mediated phenomena. 44. Synthesis of an N-substituted 4-hydroxy-5-(3-hydroxyphenyl)morphan with high affinity and selective μ-antagonist activity.

Iyer MR, Lee YS, Deschamps JR, Dersch CM, Rothman RB, Jacobson AE, Rice KC.

Eur J Med Chem. 2012 Apr;50:44-54. doi: 10.1016/j.ejmech.2012.01.025. Epub 2012 Jan 20.

PMID:
22341895
[PubMed - indexed for MEDLINE]
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9.

Probes for narcotic receptor mediated phenomena. 41. Unusual inverse μ-agonists and potent μ-opioid antagonists by modification of the N-substituent in enantiomeric 5-(3-hydroxyphenyl)morphans.

Cheng K, Lee YS, Rothman RB, Dersch CM, Bittman RW, Jacobson AE, Rice KC.

J Med Chem. 2011 Feb 24;54(4):957-69. doi: 10.1021/jm1011676. Epub 2011 Jan 19.

PMID:
21247164
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.

Ananthan S, Johnson CA, Carter RL, Clayton SD, Rice KC, Xu H, Davis P, Porreca F, Rothman RB.

J Med Chem. 1998 Jul 16;41(15):2872-81.

PMID:
9667975
[PubMed - indexed for MEDLINE]
11.

Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors.

Decker M, Si YG, Knapp BI, Bidlack JM, Neumeyer JL.

J Med Chem. 2010 Jan 14;53(1):402-18. doi: 10.1021/jm9013482.

PMID:
19928862
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists.

Cheng K, Kim IJ, Lee MJ, Adah SA, Raymond TJ, Bilsky EJ, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Rothman RB, Jacobson AE, Rice KC.

Org Biomol Chem. 2007 Apr 21;5(8):1177-90. Epub 2007 Mar 1.

PMID:
17406716
[PubMed - indexed for MEDLINE]
13.

Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans.

Ananthan S, Khare NK, Saini SK, Davis P, Dersch CM, Porreca F, Rothman RB.

Bioorg Med Chem. 2003 Sep 1;11(18):4143-54.

PMID:
12927876
[PubMed - indexed for MEDLINE]
14.

Synthesis of rac-(1R,4aR,9aR)-2-methyl-1,3,4,9a-tetrahydro-2H-1,4a-propanobenzofuro[2,3-c]pyridin-6-ol. An unusual double rearrangement leading to the ortho- and para-f oxide-bridged phenylmorphan isomers.

Kodato S, Linders JT, Gu XH, Yamada K, Flippen-Anderson JL, Deschamps JR, Jacobson AE, Rice KC.

Org Biomol Chem. 2004 Feb 7;2(3):330-6. Epub 2004 Jan 5.

PMID:
14747861
[PubMed - indexed for MEDLINE]
15.

Probes for narcotic receptor-mediated phenomena. 33. Construction of a strained trans-5,6-ring system by displacement of a nitro-activated aromatic fluorine. synthesis of the penultimate oxide-bridged phenylmorphans.

Hashimoto A, Przybyl AK, Linders JT, Kodato S, Tian X, Deschamps JR, George C, Flippen-Anderson JL, Jacobson AE, Rice KC.

J Org Chem. 2004 Aug 6;69(16):5322-7.

PMID:
15287777
[PubMed - indexed for MEDLINE]
16.

Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.

McLamore S, Ullrich T, Rothman RB, Xu H, Dersch C, Coop A, Davis P, Porreca F, Jacobson AE, Rice KC.

J Med Chem. 2001 Apr 26;44(9):1471-4.

PMID:
11311071
[PubMed - indexed for MEDLINE]
17.

Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.

Li G, Aschenbach LC, Chen J, Cassidy MP, Stevens DL, Gabra BH, Selley DE, Dewey WL, Westkaemper RB, Zhang Y.

J Med Chem. 2009 Mar 12;52(5):1416-27. doi: 10.1021/jm801272c.

PMID:
19199782
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Phenylmorphans and analogues: opioid receptor subtype selectivity and effect of conformation on activity.

Froimowitz M, Pick CG, Pasternak GW.

J Med Chem. 1992 May 1;35(9):1521-5.

PMID:
1315868
[PubMed - indexed for MEDLINE]
19.

N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.

Thomas JB, Zheng X, Mascarella SW, Rothman RB, Dersch CM, Partilla JS, Flippen-Anderson JL, George CF, Cantrell BE, Zimmerman DM, Carroll FI.

J Med Chem. 1998 Oct 8;41(21):4143-9.

PMID:
9767649
[PubMed - indexed for MEDLINE]
20.

Aminothiazolomorphinans with mixed κ and μ opioid activity.

Zhang T, Yan Z, Sromek A, Knapp BI, Scrimale T, Bidlack JM, Neumeyer JL.

J Med Chem. 2011 Mar 24;54(6):1903-13. doi: 10.1021/jm101542c. Epub 2011 Feb 25.

PMID:
21351746
[PubMed - indexed for MEDLINE]
Free PMC Article

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