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Items: 1 to 20 of 120

1.

Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels.

Khoo KK, Gupta K, Green BR, Zhang MM, Watkins M, Olivera BM, Balaram P, Yoshikami D, Bulaj G, Norton RS.

Biochemistry. 2012 Dec 11;51(49):9826-35. doi: 10.1021/bi301256s. Epub 2012 Nov 28.

2.

Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion.

Khoo KK, Feng ZP, Smith BJ, Zhang MM, Yoshikami D, Olivera BM, Bulaj G, Norton RS.

Biochemistry. 2009 Feb 17;48(6):1210-9. doi: 10.1021/bi801998a.

3.

Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics.

Han TS, Zhang MM, Walewska A, Gruszczynski P, Robertson CR, Cheatham TE 3rd, Yoshikami D, Olivera BM, Bulaj G.

ChemMedChem. 2009 Mar;4(3):406-14. doi: 10.1002/cmdc.200800292.

4.

Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency.

Kuang Z, Zhang MM, Gupta K, Gajewiak J, Gulyas J, Balaram P, Rivier JE, Olivera BM, Yoshikami D, Bulaj G, Norton RS.

ACS Chem Biol. 2013;8(6):1344-51. doi: 10.1021/cb300674x. Epub 2013 Apr 16.

5.

Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity.

Van Der Haegen A, Peigneur S, Tytgat J.

FEBS J. 2011 Sep;278(18):3408-18. doi: 10.1111/j.1742-4658.2011.08264.x. Epub 2011 Aug 24.

6.

The three-dimensional solution structure of mini-M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold.

Akcan M, Cao Y, Chongxu F, Craik DJ.

Bioorg Med Chem. 2013 Jun 15;21(12):3590-6. doi: 10.1016/j.bmc.2013.02.012. Epub 2013 Feb 22.

PMID:
23490156
8.

Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA.

McArthur JR, Singh G, McMaster D, Winkfein R, Tieleman DP, French RJ.

Mol Pharmacol. 2011 Oct;80(4):573-84. doi: 10.1124/mol.111.073460. Epub 2011 Jun 27.

9.

μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels.

Zhang MM, Han TS, Olivera BM, Bulaj G, Yoshikami D.

Biochemistry. 2010 Jun 15;49(23):4804-12. doi: 10.1021/bi100207k.

10.

Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker μ-KIIIA and its selenopeptide analogues.

Walewska A, Han TS, Zhang MM, Yoshikami D, Bulaj G, Rolka K.

Eur J Med Chem. 2013 Jul;65:144-50. doi: 10.1016/j.ejmech.2013.04.041. Epub 2013 May 1.

11.

Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels.

Bulaj G, West PJ, Garrett JE, Watkins M, Zhang MM, Norton RS, Smith BJ, Yoshikami D, Olivera BM.

Biochemistry. 2005 May 17;44(19):7259-65. Erratum in: Biochemistry. 2006 Mar 7;45(9):3116. Marsh, Maren [corrected to Watkins, Maren].

PMID:
15882064
12.

NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA.

Walewska A, Skalicky JJ, Davis DR, Zhang MM, Lopez-Vera E, Watkins M, Han TS, Yoshikami D, Olivera BM, Bulaj G.

J Am Chem Soc. 2008 Oct 29;130(43):14280-6. doi: 10.1021/ja804303p. Epub 2008 Oct 3.

13.

lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization from the venom of Conus marmoreus.

Balaji RA, Ohtake A, Sato K, Gopalakrishnakone P, Kini RM, Seow KT, Bay BH.

J Biol Chem. 2000 Dec 15;275(50):39516-22.

14.

Design of bioactive peptides from naturally occurring μ-conotoxin structures.

Stevens M, Peigneur S, Dyubankova N, Lescrinier E, Herdewijn P, Tytgat J.

J Biol Chem. 2012 Sep 7;287(37):31382-92. doi: 10.1074/jbc.M112.375733. Epub 2012 Jul 6.

15.

Characterization of novel M-superfamily conotoxins with new disulfide linkage.

Han YH, Wang Q, Jiang H, Liu L, Xiao C, Yuan DD, Shao XX, Dai QY, Cheng JS, Chi CW.

FEBS J. 2006 Nov;273(21):4972-82. Epub 2006 Oct 17.

17.

Using the deadly mu-conotoxins as probes of voltage-gated sodium channels.

Li RA, Tomaselli GF.

Toxicon. 2004 Aug;44(2):117-22. Review.

18.

Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA.

Yao S, Zhang MM, Yoshikami D, Azam L, Olivera BM, Bulaj G, Norton RS.

Biochemistry. 2008 Oct 14;47(41):10940-9. doi: 10.1021/bi801010u. Epub 2008 Sep 18.

19.

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

Zhang MM, Green BR, Catlin P, Fiedler B, Azam L, Chadwick A, Terlau H, McArthur JR, French RJ, Gulyas J, Rivier JE, Smith BJ, Norton RS, Olivera BM, Yoshikami D, Bulaj G.

J Biol Chem. 2007 Oct 19;282(42):30699-706. Epub 2007 Aug 27.

20.

Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxin.

Zhang MM, Gruszczynski P, Walewska A, Bulaj G, Olivera BM, Yoshikami D.

J Neurophysiol. 2010 Jul;104(1):88-97. doi: 10.1152/jn.00145.2010. Epub 2010 Apr 21.

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