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Results: 1 to 20 of 101

1.

TGF-β-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development?

Warburton D, Shi W, Xu B.

Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15;304(2):L83-5. doi: 10.1152/ajplung.00258.2012. Epub 2012 Nov 16. Review.

PMID:
23161884
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice.

Xu B, Chen H, Xu W, Zhang W, Buckley S, Zheng SG, Warburton D, Kolb M, Gauldie J, Shi W.

Am J Physiol Lung Cell Mol Physiol. 2012 Jul;303(2):L89-96. doi: 10.1152/ajplung.00060.2012. Epub 2012 May 18.

PMID:
22610349
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis.

Bonniaud P, Kolb M, Galt T, Robertson J, Robbins C, Stampfli M, Lavery C, Margetts PJ, Roberts AB, Gauldie J.

J Immunol. 2004 Aug 1;173(3):2099-108.

PMID:
15265946
[PubMed - indexed for MEDLINE]
Free Article
4.

Smad3 signaling involved in pulmonary fibrosis and emphysema.

Gauldie J, Kolb M, Ask K, Martin G, Bonniaud P, Warburton D.

Proc Am Thorac Soc. 2006 Nov;3(8):696-702. Review.

PMID:
17065376
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema.

Chen H, Sun J, Buckley S, Chen C, Warburton D, Wang XF, Shi W.

Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L683-91. Epub 2004 Dec 10.

PMID:
15591413
[PubMed - indexed for MEDLINE]
Free Article
6.

Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro.

Meng XM, Huang XR, Xiao J, Chung AC, Qin W, Chen HY, Lan HY.

Kidney Int. 2012 Feb;81(3):266-79. doi: 10.1038/ki.2011.327. Epub 2011 Nov 2.

PMID:
22048127
[PubMed - indexed for MEDLINE]
7.

Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice.

Farkas L, Farkas D, Warburton D, Gauldie J, Shi W, Stampfli MR, Voelkel NF, Kolb M.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L391-401. doi: 10.1152/ajplung.00369.2010. Epub 2011 Jul 8.

PMID:
21743024
[PubMed - indexed for MEDLINE]
Free Article
8.

TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis.

Bonniaud P, Margetts PJ, Ask K, Flanders K, Gauldie J, Kolb M.

J Immunol. 2005 Oct 15;175(8):5390-5.

PMID:
16210645
[PubMed - indexed for MEDLINE]
Free Article
9.

Is Smad3 a major player in signal transduction pathways leading to fibrogenesis?

Roberts AB, Piek E, Böttinger EP, Ashcroft G, Mitchell JB, Flanders KC.

Chest. 2001 Jul;120(1 Suppl):43S-47S.

PMID:
11451911
[PubMed - indexed for MEDLINE]
10.

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.

Zhang Y, Feng XH, Derynck R.

Nature. 1998 Aug 27;394(6696):909-13. Erratum in: Nature 1998 Dec 3;396(6710):491.

PMID:
9732876
[PubMed - indexed for MEDLINE]
11.

Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-β/Smad3 pathway.

Huang XZ, Wen D, Zhang M, Xie Q, Ma L, Guan Y, Ren Y, Chen J, Hao CM.

J Cell Biochem. 2014 May;115(5):996-1005. doi: 10.1002/jcb.24748.

PMID:
24356887
[PubMed - indexed for MEDLINE]
12.

Cited2 modulates TGF-beta-mediated upregulation of MMP9.

Chou YT, Wang H, Chen Y, Danielpour D, Yang YC.

Oncogene. 2006 Sep 7;25(40):5547-60. Epub 2006 Apr 17.

PMID:
16619037
[PubMed - indexed for MEDLINE]
13.

miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice.

Xiao J, Meng XM, Huang XR, Chung AC, Feng YL, Hui DS, Yu CM, Sung JJ, Lan HY.

Mol Ther. 2012 Jun;20(6):1251-60. doi: 10.1038/mt.2012.36. Epub 2012 Mar 6.

PMID:
22395530
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Transgelin is a direct target of TGF-beta/Smad3-dependent epithelial cell migration in lung fibrosis.

Yu H, Königshoff M, Jayachandran A, Handley D, Seeger W, Kaminski N, Eickelberg O.

FASEB J. 2008 Jun;22(6):1778-89. doi: 10.1096/fj.07-083857. Epub 2008 Feb 1.

PMID:
18245174
[PubMed - indexed for MEDLINE]
Free Article
15.

EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts.

Li YJ, Azuma A, Usuki J, Abe S, Matsuda K, Sunazuka T, Shimizu T, Hirata Y, Inagaki H, Kawada T, Takahashi S, Kudoh S, Omura S.

Respir Res. 2006 Jan 27;7:16.

PMID:
16438734
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

ERK5 inhibition ameliorates pulmonary fibrosis via regulating Smad3 acetylation.

Kim S, Lim JH, Woo CH.

Am J Pathol. 2013 Dec;183(6):1758-68. doi: 10.1016/j.ajpath.2013.08.014. Epub 2013 Oct 1.

PMID:
24095924
[PubMed - indexed for MEDLINE]
Free Article
17.

Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-beta signaling.

Zhao Y, Geverd DA.

Biochem Biophys Res Commun. 2002 Jun 7;294(2):319-23.

PMID:
12051713
[PubMed - indexed for MEDLINE]
18.

Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice.

Mitani A, Nagase T, Fukuchi K, Aburatani H, Makita R, Kurihara H.

Am J Respir Crit Care Med. 2009 Aug 15;180(4):326-38. doi: 10.1164/rccm.200812-1827OC. Epub 2009 Jun 4.

PMID:
19498055
[PubMed - indexed for MEDLINE]
19.

Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3.

Yuan W, Varga J.

J Biol Chem. 2001 Oct 19;276(42):38502-10. Epub 2001 Aug 13.

PMID:
11502752
[PubMed - indexed for MEDLINE]
Free Article
20.

Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation.

Gu L, Zhu YJ, Yang X, Guo ZJ, Xu WB, Tian XL.

Acta Pharmacol Sin. 2007 Mar;28(3):382-91.

PMID:
17303001
[PubMed - indexed for MEDLINE]
Free Article

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