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Local autoantigen expression as essential gatekeeper of memory T-cell recruitment to islet grafts in diabetic hosts.

Alkemade GM, Clemente-Casares X, Yu Z, Xu BY, Wang J, Tsai S, Wright JR Jr, Roep BO, Santamaria P.

Diabetes. 2013 Mar;62(3):905-11. doi: 10.2337/db12-0600. Epub 2012 Nov 16.


In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammation.

Wang J, Tsai S, Shameli A, Yamanouchi J, Alkemade G, Santamaria P.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9317-22. doi: 10.1073/pnas.0913835107. Epub 2010 May 3.


Genetic and therapeutic control of diabetogenic CD8+ T cells.

Santamaria P.

Novartis Found Symp. 2008;292:130-6; discussion 136-45, 202-3.


Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage.

Diz R, Garland A, Vincent BG, Johnson MC, Spidale N, Wang B, Tisch R.

PLoS One. 2012;7(12):e52054. doi: 10.1371/journal.pone.0052054. Epub 2012 Dec 14.


Autoantigen recognition is required for recruitment of IGRP(206-214)-autoreactive CD8+ T cells but is dispensable for tolerance.

Wang J, Tsai S, Han B, Tailor P, Santamaria P.

J Immunol. 2012 Sep 15;189(6):2975-84. doi: 10.4049/jimmunol.1201787. Epub 2012 Aug 20.


Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

Krishnamurthy B, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, Colman PG, Harrison LC, Lew AM, Thomas HE, Kay TW.

J Clin Invest. 2006 Dec;116(12):3258-65.


MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo.

Kupfer TM, Crawford ML, Pham K, Gill RG.

J Immunol. 2005 Aug 15;175(4):2309-16.


Prospective prediction of spontaneous but not recurrent autoimmune diabetes in the non-obese diabetic mouse.

Trudeau JD, Chandler T, Soukhatcheva G, Verchere CB, Tan R.

Diabetologia. 2007 May;50(5):1015-23. Epub 2007 Mar 2.


Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

Lieberman SM, Evans AM, Han B, Takaki T, Vinnitskaya Y, Caldwell JA, Serreze DV, Shabanowitz J, Hunt DF, Nathenson SG, Santamaria P, DiLorenzo TP.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8384-8. Epub 2003 Jun 18.


Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach.

Niens M, Grier AE, Marron M, Kay TW, Greiner DL, Serreze DV.

Diabetes. 2011 Apr;60(4):1229-36. doi: 10.2337/db10-1523. Epub 2011 Feb 23.


Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice.

Vincent BG, Young EF, Buntzman AS, Stevens R, Kepler TB, Tisch RM, Frelinger JA, Hess PR.

J Immunol. 2010 Apr 15;184(8):4196-204. doi: 10.4049/jimmunol.0903931. Epub 2010 Mar 10.


Both CD4+ and CD8+ T-cells in syngeneic islet grafts in NOD mice produce interferon-gamma during beta-cell destruction.

Suarez-Pinzon W, Rajotte RV, Mosmann TR, Rabinovitch A.

Diabetes. 1996 Oct;45(10):1350-7.


HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.

Takaki T, Marron MP, Mathews CE, Guttmann ST, Bottino R, Trucco M, DiLorenzo TP, Serreze DV.

J Immunol. 2006 Mar 1;176(5):3257-65.


CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles.

Martinez X, Kreuwel HT, Redmond WL, Trenney R, Hunter K, Rosen H, Sarvetnick N, Wicker LS, Sherman LA.

J Immunol. 2005 Aug 1;175(3):1677-85.


Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice.

Oeser JK, Parekh VV, Wang Y, Jegadeesh NK, Sarkar SA, Wong R, Lee CE, Pound LD, Hutton JC, Van Kaer L, O'Brien RM.

Diabetes. 2011 Nov;60(11):2922-7. doi: 10.2337/db11-0220. Epub 2011 Sep 6.


Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of beta cell autoantigens.

Yamanouchi J, Verdaguer J, Han B, Amrani A, Serra P, Santamaria P.

J Immunol. 2003 Dec 15;171(12):6900-9.

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