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Results: 1 to 20 of 96

1.

The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies.

Wang D, Li L, Yang H, Ferguson SS, Baer MR, Gartenhaus RB, Wang H.

Blood. 2013 Jan 10;121(2):329-38. doi: 10.1182/blood-2012-06-436691. Epub 2012 Nov 16.

PMID:
23160467
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes.

Wang D, Li L, Fuhrman J, Ferguson S, Wang H.

Pharm Res. 2011 Aug;28(8):2034-44. doi: 10.1007/s11095-011-0429-2. Epub 2011 Apr 13.

PMID:
21487929
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells.

Li L, Hassan HE, Tolson AH, Ferguson SS, Eddington ND, Wang H.

J Pharmacol Exp Ther. 2010 Dec;335(3):562-71. doi: 10.1124/jpet.110.173187. Epub 2010 Sep 9.

PMID:
20829393
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2.

Rhodes SP, Otten JN, Hingorani GP, Hartley DP, Franklin RB.

J Pharmacol Toxicol Methods. 2011 May-Jun;63(3):223-6. doi: 10.1016/j.vascn.2010.11.002. Epub 2010 Nov 24.

PMID:
21111054
[PubMed - indexed for MEDLINE]
5.

Improvement of cyclophosphamide activation by CYP2B6 mutants: from in silico to ex vivo.

Nguyen TA, Tychopoulos M, Bichat F, Zimmermann C, Flinois JP, Diry M, Ahlberg E, Delaforge M, Corcos L, Beaune P, Dansette P, André F, de Waziers I.

Mol Pharmacol. 2008 Apr;73(4):1122-33. doi: 10.1124/mol.107.042861. Epub 2008 Jan 22. Erratum in: Mol Pharmacol. 2008 Jun;73(6):1866.

PMID:
18212249
[PubMed - indexed for MEDLINE]
Free Article
6.

The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes.

Lindley C, Hamilton G, McCune JS, Faucette S, Shord SS, Hawke RL, Wang H, Gilbert D, Jolley S, Yan B, LeCluyse EL.

Drug Metab Dispos. 2002 Jul;30(7):814-22.

PMID:
12065440
[PubMed - indexed for MEDLINE]
Free Article
7.

Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+.

Doloff JC, Su T, Waxman DJ.

BMC Cancer. 2010 Sep 13;10:487. doi: 10.1186/1471-2407-10-487.

PMID:
20836875
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Nuclear translocation of adenoviral-enhanced yellow fluorescent protein-tagged-human constitutive androstane receptor (hCAR): a novel tool for screening hCAR activators in human primary hepatocytes.

Li H, Chen T, Cottrell J, Wang H.

Drug Metab Dispos. 2009 May;37(5):1098-106. doi: 10.1124/dmd.108.026005. Epub 2009 Feb 5.

PMID:
19196842
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.

Drug Metab Dispos. 2007 Jul;35(7):1032-41. Epub 2007 Mar 28.

PMID:
17392393
[PubMed - indexed for MEDLINE]
Free Article
11.

Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).

Anderson LE, Dring AM, Hamel LD, Stoner MA.

Toxicol Lett. 2011 Apr 25;202(2):148-54. doi: 10.1016/j.toxlet.2011.02.004. Epub 2011 Feb 18.

PMID:
21315811
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.

Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H.

J Pharmacol Exp Ther. 2006 Jun;317(3):1200-9. Epub 2006 Mar 2.

PMID:
16513849
[PubMed - indexed for MEDLINE]
Free Article
13.

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide.

Huang Z, Roy P, Waxman DJ.

Biochem Pharmacol. 2000 Apr 15;59(8):961-72.

PMID:
10692561
[PubMed - indexed for MEDLINE]
14.

Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies.

Kenny JR, Chen L, McGinnity DF, Grime K, Shakesheff KM, Thomson B, Riley R.

Xenobiotica. 2008 Dec;38(12):1500-17. doi: 10.1080/00498250802495846.

PMID:
18989830
[PubMed - indexed for MEDLINE]
15.

Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes.

Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL.

J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):43-58. doi: 10.1002/jbt.20264.

PMID:
19202563
[PubMed - indexed for MEDLINE]
16.

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.

Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL.

J Biol Chem. 2003 Apr 18;278(16):14146-52. Epub 2003 Feb 5.

PMID:
12571232
[PubMed - indexed for MEDLINE]
Free Article
17.

Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy.

Koh KH, Jurkovic S, Yang K, Choi SY, Jung JW, Kim KP, Zhang W, Jeong H.

Biochem Pharmacol. 2012 Jul 1;84(1):93-103. doi: 10.1016/j.bcp.2012.03.016. Epub 2012 Mar 30.

PMID:
22484313
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy.

Jounaidi Y, Hecht JE, Waxman DJ.

Cancer Res. 1998 Oct 1;58(19):4391-401.

PMID:
9766669
[PubMed - indexed for MEDLINE]
Free Article
19.

Coordinated roles of pregnane X receptor and constitutive androstane receptor in autoinduction of voriconazole metabolism in mice.

Ohbuchi M, Yoshinari K, Kaneko H, Matsumoto S, Inoue A, Kawamura A, Usui T, Yamazoe Y.

Antimicrob Agents Chemother. 2013 Mar;57(3):1332-8. doi: 10.1128/AAC.01900-12. Epub 2012 Dec 28.

PMID:
23274663
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A virus-directed enzyme prodrug therapy (VDEPT) strategy for lung cancer using a CYP2B6/NADPH-cytochrome P450 reductase fusion protein.

Tychopoulos M, Corcos L, Genne P, Beaune P, de Waziers I.

Cancer Gene Ther. 2005 May;12(5):497-508.

PMID:
15746946
[PubMed - indexed for MEDLINE]

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