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Results: 1 to 20 of 128

1.

Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway.

Ahner A, Gong X, Schmidt BZ, Peters KW, Rabeh WM, Thibodeau PH, Lukacs GL, Frizzell RA.

Mol Biol Cell. 2013 Jan;24(2):74-84. doi: 10.1091/mbc.E12-09-0678. Epub 2012 Nov 14.

PMID:
23155000
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Cystic fibrosis transmembrane conductance regulator degradation: cross-talk between the ubiquitylation and SUMOylation pathways.

Ahner A, Gong X, Frizzell RA.

FEBS J. 2013 Sep;280(18):4430-8. doi: 10.1111/febs.12415. Epub 2013 Jul 22. Review.

PMID:
23809253
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

BAG-1 stabilizes mutant F508del-CFTR in a ubiquitin-like-domain-dependent manner.

Mendes F, Farinha CM, FelĂ­cio V, Alves PC, Vieira I, Amaral MD.

Cell Physiol Biochem. 2012;30(5):1120-33. doi: 10.1159/000343303. Epub 2012 Oct 5.

PMID:
23178238
[PubMed - indexed for MEDLINE]
4.

Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622.

Norez C, Bilan F, Kitzis A, Mettey Y, Becq F.

J Pharmacol Exp Ther. 2008 Apr;325(1):89-99. doi: 10.1124/jpet.107.134502. Epub 2008 Jan 29.

PMID:
18230692
[PubMed - indexed for MEDLINE]
Free Article
5.

Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone.

Scott-Ward TS, Amaral MD.

FEBS J. 2009 Dec;276(23):7097-109. doi: 10.1111/j.1742-4658.2009.07421.x. Epub 2009 Oct 29.

PMID:
19878303
[PubMed - indexed for MEDLINE]
6.

Kaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivation.

Izumiya Y, Kobayashi K, Kim KY, Pochampalli M, Izumiya C, Shevchenko B, Wang DH, Huerta SB, Martinez A, Campbell M, Kung HJ.

PLoS Pathog. 2013;9(8):e1003506. doi: 10.1371/journal.ppat.1003506. Epub 2013 Aug 22.

PMID:
23990779
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms.

Maroui MA, Kheddache-Atmane S, El Asmi F, Dianoux L, Aubry M, Chelbi-Alix MK.

PLoS One. 2012;7(9):e44949. doi: 10.1371/journal.pone.0044949. Epub 2012 Sep 18.

PMID:
23028697
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.

Tatham MH, Geoffroy MC, Shen L, Plechanovova A, Hattersley N, Jaffray EG, Palvimo JJ, Hay RT.

Nat Cell Biol. 2008 May;10(5):538-46. doi: 10.1038/ncb1716. Epub 2008 Apr 13.

PMID:
18408734
[PubMed - indexed for MEDLINE]
9.
10.

Rescue of F508del-CFTR by RXR motif inactivation triggers proteome modulation associated with the unfolded protein response.

Gomes-Alves P, Couto F, Pesquita C, Coelho AV, Penque D.

Biochim Biophys Acta. 2010 Apr;1804(4):856-65. doi: 10.1016/j.bbapap.2009.12.013. Epub 2010 Jan 4.

PMID:
20044041
[PubMed - indexed for MEDLINE]
Free Article
11.

Rescue of epithelial HCO3- secretion in murine intestine by apical membrane expression of the cystic fibrosis transmembrane conductance regulator mutant F508del.

Xiao F, Li J, Singh AK, Riederer B, Wang J, Sultan A, Park H, Lee MG, Lamprecht G, Scholte BJ, De Jonge HR, Seidler U.

J Physiol. 2012 Nov 1;590(Pt 21):5317-34. doi: 10.1113/jphysiol.2012.232124. Epub 2012 Jul 16.

PMID:
22802588
[PubMed - indexed for MEDLINE]
Free PMC Article
12.
13.

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR).

El Khouri E, Le Pavec G, Toledano MB, Delaunay-Moisan A.

J Biol Chem. 2013 Oct 25;288(43):31177-91. doi: 10.1074/jbc.M113.470500. Epub 2013 Sep 9.

PMID:
24019521
[PubMed - indexed for MEDLINE]
14.

Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation.

Henderson MJ, Vij N, Zeitlin PL.

J Biol Chem. 2010 Apr 9;285(15):11314-25. doi: 10.1074/jbc.M109.044057. Epub 2010 Feb 10.

PMID:
20147297
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.

Younger JM, Chen L, Ren HY, Rosser MF, Turnbull EL, Fan CY, Patterson C, Cyr DM.

Cell. 2006 Aug 11;126(3):571-82.

PMID:
16901789
[PubMed - indexed for MEDLINE]
Free Article
16.

Human heat shock protein 105/110 kDa (Hsp105/110) regulates biogenesis and quality control of misfolded cystic fibrosis transmembrane conductance regulator at multiple levels.

Saxena A, Banasavadi-Siddegowda YK, Fan Y, Bhattacharya S, Roy G, Giovannucci DR, Frizzell RA, Wang X.

J Biol Chem. 2012 Jun 1;287(23):19158-70. doi: 10.1074/jbc.M111.297580. Epub 2012 Apr 13.

PMID:
22505710
[PubMed - indexed for MEDLINE]
Free PMC Article
17.
18.

Probing conformational rescue induced by a chemical corrector of F508del-cystic fibrosis transmembrane conductance regulator (CFTR) mutant.

Yu W, Kim Chiaw P, Bear CE.

J Biol Chem. 2011 Jul 15;286(28):24714-25. doi: 10.1074/jbc.M111.239699. Epub 2011 May 21.

PMID:
21602569
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Structural basis for regulation of poly-SUMO chain by a SUMO-like domain of Nip45.

Sekiyama N, Arita K, Ikeda Y, Hashiguchi K, Ariyoshi M, Tochio H, Saitoh H, Shirakawa M.

Proteins. 2010 May 1;78(6):1491-502. doi: 10.1002/prot.22667.

PMID:
20077568
[PubMed - indexed for MEDLINE]
20.

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition.

Luciani A, Villella VR, Esposito S, Brunetti-Pierri N, Medina D, Settembre C, Gavina M, Pulze L, Giardino I, Pettoello-Mantovani M, D'Apolito M, Guido S, Masliah E, Spencer B, Quaratino S, Raia V, Ballabio A, Maiuri L.

Nat Cell Biol. 2010 Sep;12(9):863-75. doi: 10.1038/ncb2090. Epub 2010 Aug 15.

PMID:
20711182
[PubMed - indexed for MEDLINE]

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