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Results: 1 to 20 of 145

1.

Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs.

Sato N, Okochi M, Shinohara M, Thinakaran G, Takeda S, Fukumori A, Shinohara-Noma M, Mori-Ueda M, Hamada H, Takeda M, Rakugi H, Morishita R.

PLoS One. 2012;7(11):e48551. doi: 10.1371/journal.pone.0048551. Epub 2012 Nov 12. Erratum in: PLoS One. 2012;7(11). doi:10.1371/annotation/5cac3524-f2a4-4997-ba21-a5f1d8551f59.

PMID:
23152781
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.

J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21.

PMID:
18430735
[PubMed - indexed for MEDLINE]
Free Article
3.

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.

Biochemistry. 1998 Nov 24;37(47):16465-71.

PMID:
9843412
[PubMed - indexed for MEDLINE]
4.

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.

Wanngren J, Lara P, Ojemalm K, Maioli S, Moradi N, Chen L, Tjernberg LO, Lundkvist J, Nilsson I, Karlström H.

FEBS Open Bio. 2014 Apr 24;4:393-406. doi: 10.1016/j.fob.2014.04.006. eCollection 2014.

PMID:
24918054
[PubMed]
Free PMC Article
5.

Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.

Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.

Neurosci Res. 2007 Mar;57(3):446-53. Epub 2007 Jan 8.

PMID:
17210196
[PubMed - indexed for MEDLINE]
6.

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.

Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR.

Hum Mol Genet. 2004 Jan 15;13(2):159-70. Epub 2003 Nov 25.

PMID:
14645205
[PubMed - indexed for MEDLINE]
Free Article
7.

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT.

J Neurosci. 2005 Mar 16;25(11):3009-17.

PMID:
15772361
[PubMed - indexed for MEDLINE]
Free Article
8.

Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.

Quintero-Monzon O, Martin MM, Fernandez MA, Cappello CA, Krzysiak AJ, Osenkowski P, Wolfe MS.

Biochemistry. 2011 Oct 25;50(42):9023-35. doi: 10.1021/bi2007146. Epub 2011 Sep 30.

PMID:
21919498
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease.

Svedružić ZM, Popović K, Smoljan I, Sendula-Jengić V.

PLoS One. 2012;7(3):e32293. doi: 10.1371/journal.pone.0032293. Epub 2012 Mar 30.

PMID:
22479317
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Activation and intrinsic gamma-secretase activity of presenilin 1.

Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21435-40. doi: 10.1073/pnas.1013246107. Epub 2010 Nov 29.

PMID:
21115843
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.

Heilig EA, Xia W, Shen J, Kelleher RJ 3rd.

J Biol Chem. 2010 Jul 16;285(29):22350-9. doi: 10.1074/jbc.M110.116962. Epub 2010 May 11.

PMID:
20460383
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
[PubMed - indexed for MEDLINE]
13.

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.

Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D.

Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8972-7. Epub 2005 Jun 10.

PMID:
15951428
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, Parker EM.

Biochemistry. 2005 Mar 22;44(11):4450-7.

PMID:
15766275
[PubMed - indexed for MEDLINE]
15.
16.

Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.

Pintchovski SA, Schenk DB, Basi GS.

Curr Alzheimer Res. 2013 Jan;10(1):4-10.

PMID:
22950863
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.

Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME.

J Neurochem. 2007 Aug;102(3):619-26. Erratum in: J Neurochem. 2007 Nov;103(3):1272. Bogush, Alexey [added].

PMID:
17630980
[PubMed - indexed for MEDLINE]
18.

Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.

Kumar VB, Franko M, Banks WA, Kasinadhuni P, Farr SA, Vyas K, Choudhuri V, Morley JE.

J Exp Biol. 2009 Feb;212(Pt 4):494-8. doi: 10.1242/jeb.022780.

PMID:
19181896
[PubMed - indexed for MEDLINE]
Free Article
19.

Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.

Sultana R, Robinson RA, Di Domenico F, Abdul HM, St Clair DK, Markesbery WR, Cai J, Pierce WM, Butterfield DA.

J Proteomics. 2011 Oct 19;74(11):2430-40. doi: 10.1016/j.jprot.2011.06.015. Epub 2011 Jun 25.

PMID:
21726674
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.

Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS.

Hum Mol Genet. 2008 Nov 15;17(22):3474-86. doi: 10.1093/hmg/ddn240. Epub 2008 Aug 11.

PMID:
18694898
[PubMed - indexed for MEDLINE]
Free PMC Article

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