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Results: 1 to 20 of 101

1.

Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner.

Kaul A, Chen YH, Emnett RJ, Dahiya S, Gutmann DH.

Genes Dev. 2012 Dec 1;26(23):2561-6. doi: 10.1101/gad.200907.112. Epub 2012 Nov 14.

PMID:
23152448
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.

Banerjee S, Crouse NR, Emnett RJ, Gianino SM, Gutmann DH.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15996-6001. doi: 10.1073/pnas.1019012108. Epub 2011 Sep 6.

PMID:
21896734
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects.

Kaul A, Chen YH, Emnett RJ, Gianino SM, Gutmann DH.

Genesis. 2013 Oct;51(10):708-16. doi: 10.1002/dvg.22415. Epub 2013 Aug 16.

PMID:
23893969
[PubMed - indexed for MEDLINE]
4.

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.

Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP.

J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.

PMID:
15150271
[PubMed - indexed for MEDLINE]
Free Article
6.

Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling.

Scheidenhelm DK, Cresswell J, Haipek CA, Fleming TP, Mercer RW, Gutmann DH.

Mol Cell Biol. 2005 Apr;25(8):3151-62.

PMID:
15798201
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J.

Curr Biol. 2003 Aug 5;13(15):1259-68.

PMID:
12906785
[PubMed - indexed for MEDLINE]
Free Article
8.

Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas.

Sievert AJ, Lang SS, Boucher KL, Madsen PJ, Slaunwhite E, Choudhari N, Kellet M, Storm PB, Resnick AC.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5957-62. doi: 10.1073/pnas.1219232110. Epub 2013 Mar 26. Erratum in: Proc Natl Acad Sci U S A. 2013 May 21;110(21):8750.

PMID:
23533272
[PubMed - indexed for MEDLINE]
Free PMC Article
9.
10.

Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation.

Uhlmann EJ, Li W, Scheidenhelm DK, Gau CL, Tamanoi F, Gutmann DH.

Glia. 2004 Aug 1;47(2):180-8.

PMID:
15185396
[PubMed - indexed for MEDLINE]
11.

Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner.

Lee da Y, Yeh TH, Emnett RJ, White CR, Gutmann DH.

Genes Dev. 2010 Oct 15;24(20):2317-29. doi: 10.1101/gad.1957110. Epub 2010 Sep 28.

PMID:
20876733
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

GLUT1 enhances mTOR activity independently of TSC2 and AMPK.

Buller CL, Heilig CW, Brosius FC 3rd.

Am J Physiol Renal Physiol. 2011 Sep;301(3):F588-96. doi: 10.1152/ajprenal.00472.2010. Epub 2011 May 25.

PMID:
21613414
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target.

Hütt-Cabezas M, Karajannis MA, Zagzag D, Shah S, Horkayne-Szakaly I, Rushing EJ, Cameron JD, Jain D, Eberhart CG, Raabe EH, Rodriguez FJ.

Neuro Oncol. 2013 Dec;15(12):1604-14. doi: 10.1093/neuonc/not132. Epub 2013 Nov 6.

PMID:
24203892
[PubMed - indexed for MEDLINE]
14.

Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas.

Tian Y, Rich BE, Vena N, Craig JM, Macconaill LE, Rajaram V, Goldman S, Taha H, Mahmoud M, Ozek M, Sav A, Longtine JA, Lindeman NI, Garraway LA, Ligon AH, Stiles CD, Santagata S, Chan JA, Kieran MW, Ligon KL.

J Mol Diagn. 2011 Nov;13(6):669-77. doi: 10.1016/j.jmoldx.2011.07.002. Epub 2011 Aug 30.

PMID:
21884820
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Rheb, an activator of target of rapamycin, in the blackback land crab, Gecarcinus lateralis: cloning and effects of molting and unweighting on expression in skeletal muscle.

MacLea KS, Abuhagr AM, Pitts NL, Covi JA, Bader BD, Chang ES, Mykles DL.

J Exp Biol. 2012 Feb 15;215(Pt 4):590-604. doi: 10.1242/jeb.062869.

PMID:
22279066
[PubMed - indexed for MEDLINE]
Free Article
16.

Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation.

Robinson JP, VanBrocklin MW, Guilbeault AR, Signorelli DL, Brandner S, Holmen SL.

Oncogene. 2010 Jan 21;29(3):335-44. doi: 10.1038/onc.2009.333. Epub 2009 Oct 26.

PMID:
19855433
[PubMed - indexed for MEDLINE]
17.

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth.

Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden KL, Meloche S, Roux PP.

Oncogene. 2013 Jun 13;32(24):2917-26. doi: 10.1038/onc.2012.312. Epub 2012 Jul 16.

PMID:
22797077
[PubMed - indexed for MEDLINE]
18.

BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.

Lin A, Rodriguez FJ, Karajannis MA, Williams SC, Legault G, Zagzag D, Burger PC, Allen JC, Eberhart CG, Bar EE.

J Neuropathol Exp Neurol. 2012 Jan;71(1):66-72. doi: 10.1097/NEN.0b013e31823f2cb0.

PMID:
22157620
[PubMed - indexed for MEDLINE]
19.

A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy.

Goodman CA, Miu MH, Frey JW, Mabrey DM, Lincoln HC, Ge Y, Chen J, Hornberger TA.

Mol Biol Cell. 2010 Sep 15;21(18):3258-68. doi: 10.1091/mbc.E10-05-0454. Epub 2010 Jul 28.

PMID:
20668162
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.

Misra UK, Pizzo SV.

PLoS One. 2012;7(12):e51735. doi: 10.1371/journal.pone.0051735. Epub 2012 Dec 14.

PMID:
23272152
[PubMed - indexed for MEDLINE]
Free PMC Article

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