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Results: 1 to 20 of 105

1.

Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans.

Khetani SR, Kanchagar C, Ukairo O, Krzyzewski S, Moore A, Shi J, Aoyama S, Aleo M, Will Y.

Toxicol Sci. 2013 Mar;132(1):107-17. doi: 10.1093/toxsci/kfs326. Epub 2012 Nov 14.

PMID:
23152190
[PubMed - indexed for MEDLINE]
Free Article
2.

Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans.

Atienzar FA, Novik EI, Gerets HH, Parekh A, Delatour C, Cardenas A, MacDonald J, Yarmush ML, Dhalluin S.

Toxicol Appl Pharmacol. 2014 Feb 15;275(1):44-61. doi: 10.1016/j.taap.2013.11.022. Epub 2013 Dec 10.

PMID:
24333257
[PubMed - indexed for MEDLINE]
3.

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.

Howell BA, Yang Y, Kumar R, Woodhead JL, Harrill AH, Clewell HJ 3rd, Andersen ME, Siler SQ, Watkins PB.

J Pharmacokinet Pharmacodyn. 2012 Oct;39(5):527-41. doi: 10.1007/s10928-012-9266-0. Epub 2012 Aug 9.

PMID:
22875368
[PubMed - indexed for MEDLINE]
4.

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model.

Chen M, Tung CW, Shi Q, Guo L, Shi L, Fang H, Borlak J, Tong W.

Arch Toxicol. 2014 Jul;88(7):1439-49. doi: 10.1007/s00204-014-1276-9. Epub 2014 Jun 11.

PMID:
24958025
[PubMed - indexed for MEDLINE]
5.

Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes.

Ogimura E, Sekine S, Horie T.

Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):313-7. doi: 10.1016/j.bbrc.2011.11.032. Epub 2011 Nov 15.

PMID:
22108051
[PubMed - indexed for MEDLINE]
6.

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.

Aleo MD, Luo Y, Swiss R, Bonin PD, Potter DM, Will Y.

Hepatology. 2014 Sep;60(3):1015-22. doi: 10.1002/hep.27206. Epub 2014 Jul 14.

PMID:
24799086
[PubMed - indexed for MEDLINE]
7.

Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes.

Garside H, Marcoe KF, Chesnut-Speelman J, Foster AJ, Muthas D, Kenna JG, Warrior U, Bowes J, Baumgartner J.

Toxicol In Vitro. 2014 Mar;28(2):171-81. doi: 10.1016/j.tiv.2013.10.015. Epub 2013 Nov 1.

PMID:
24189122
[PubMed - indexed for MEDLINE]
Free Article
8.

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity.

Kostadinova R, Boess F, Applegate D, Suter L, Weiser T, Singer T, Naughton B, Roth A.

Toxicol Appl Pharmacol. 2013 Apr 1;268(1):1-16. doi: 10.1016/j.taap.2013.01.012. Epub 2013 Jan 23.

PMID:
23352505
[PubMed - indexed for MEDLINE]
9.

Hormone and Drug-Mediated Modulation of Glucose Metabolism in a Microscale Model of the Human Liver.

Davidson MD, Lehrer M, Khetani SR.

Tissue Eng Part C Methods. 2014 Dec 17. [Epub ahead of print]

PMID:
25517416
[PubMed - as supplied by publisher]
10.

Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria.

Porceddu M, Buron N, Roussel C, Labbe G, Fromenty B, Borgne-Sanchez A.

Toxicol Sci. 2012 Oct;129(2):332-45. doi: 10.1093/toxsci/kfs197.

PMID:
22987451
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins.

Usui T, Mise M, Hashizume T, Yabuki M, Komuro S.

Drug Metab Dispos. 2009 Dec;37(12):2383-92. doi: 10.1124/dmd.109.028860. Epub 2009 Aug 31.

PMID:
19720731
[PubMed - indexed for MEDLINE]
Free Article
12.

A high content screening assay to predict human drug-induced liver injury during drug discovery.

Persson M, Løye AF, Mow T, Hornberg JJ.

J Pharmacol Toxicol Methods. 2013 Nov-Dec;68(3):302-13. doi: 10.1016/j.vascn.2013.08.001. Epub 2013 Aug 8.

PMID:
23933113
[PubMed - indexed for MEDLINE]
13.

Is toxicogenomics a more reliable and sensitive biomarker than conventional indicators from rats to predict drug-induced liver injury in humans?

Zhang M, Chen M, Tong W.

Chem Res Toxicol. 2012 Jan 13;25(1):122-9. doi: 10.1021/tx200320e. Epub 2011 Dec 13.

PMID:
22122743
[PubMed - indexed for MEDLINE]
14.

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.

PLoS Comput Biol. 2011 Dec;7(12):e1002310. doi: 10.1371/journal.pcbi.1002310. Epub 2011 Dec 15.

PMID:
22194678
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Detection of nanolevel drug metabolites in an organotypic culture of primary human hepatocytes and porcine hepatocytes with special reference to a two-compartment model.

Acikgöz A, Giri S, Bader A.

Int J Nanomedicine. 2012;7:5859-72. doi: 10.2147/IJN.S29651. Epub 2012 Nov 27.

PMID:
23226017
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Cellular imaging predictions of clinical drug-induced liver injury.

Xu JJ, Henstock PV, Dunn MC, Smith AR, Chabot JR, de Graaf D.

Toxicol Sci. 2008 Sep;105(1):97-105. doi: 10.1093/toxsci/kfn109. Epub 2008 Jun 3.

PMID:
18524759
[PubMed - indexed for MEDLINE]
Free Article
17.

Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats.

Yamazaki M, Miyake M, Sato H, Masutomi N, Tsutsui N, Adam KP, Alexander DC, Lawton KA, Milburn MV, Ryals JA, Wulff JE, Guo L.

Toxicol Appl Pharmacol. 2013 Apr 1;268(1):79-89. doi: 10.1016/j.taap.2013.01.018. Epub 2013 Jan 27.

PMID:
23360887
[PubMed - indexed for MEDLINE]
18.

Drug-induced hepatotoxicity test using gamma-glutamylcysteine synthetase knockdown rat.

Morita M, Akai S, Hosomi H, Tsuneyama K, Nakajima M, Yokoi T.

Toxicol Lett. 2009 Sep 10;189(2):159-65. doi: 10.1016/j.toxlet.2009.05.016. Epub 2009 May 27.

PMID:
19481141
[PubMed - indexed for MEDLINE]
19.

Cytotoxicity of naphthylisothiocyanates in rat hepatocyte-neutrophil cocultures.

Jean PA, Kessel SL, Hill DA, Roth RA.

Toxicol Lett. 1998 May;95(3):155-63.

PMID:
9704817
[PubMed - indexed for MEDLINE]
20.

Development of an in vitro liver toxicity prediction model based on longer term primary rat hepatocyte culture.

Hrach J, Mueller SO, Hewitt P.

Toxicol Lett. 2011 Oct 10;206(2):189-96. doi: 10.1016/j.toxlet.2011.07.012. Epub 2011 Jul 23.

PMID:
21807079
[PubMed - indexed for MEDLINE]
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