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1.

CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion.

Zhu AZ, Cox LS, Nollen N, Faseru B, Okuyemi KS, Ahluwalia JS, Benowitz NL, Tyndale RF.

Clin Pharmacol Ther. 2012 Dec;92(6):771-7. doi: 10.1038/clpt.2012.186. Epub 2012 Nov 14.

2.

CYP2B6 genotype alters abstinence rates in a bupropion smoking cessation trial.

Lee AM, Jepson C, Hoffmann E, Epstein L, Hawk LW, Lerman C, Tyndale RF.

Biol Psychiatry. 2007 Sep 15;62(6):635-41. Epub 2007 Jan 16.

PMID:
17223085
3.

Effects of woohwangcheongsimwon suspension on the pharmacokinetics of bupropion and its active metabolite, 4-hydroxybupropion, in healthy subjects.

Kim H, Bae SK, Park SJ, Shim EJ, Kim HS, Shon JH, Liu KH, Shin JG.

Br J Clin Pharmacol. 2010 Jul;70(1):126-31. doi: 10.1111/j.1365-2125.2010.03661.x.

4.

Bupropion metabolism by human placenta.

Wang X, Abdelrahman DR, Zharikova OL, Patrikeeva SL, Hankins GD, Ahmed MS, Nanovskaya TN.

Biochem Pharmacol. 2010 Jun 1;79(11):1684-90. doi: 10.1016/j.bcp.2010.01.026. Epub 2010 Jan 28.

5.

Gene variants in CYP2C19 are associated with altered in vivo bupropion pharmacokinetics but not bupropion-assisted smoking cessation outcomes.

Zhu AZ, Zhou Q, Cox LS, Ahluwalia JS, Benowitz NL, Tyndale RF.

Drug Metab Dispos. 2014 Nov;42(11):1971-7. doi: 10.1124/dmd.114.060285. Epub 2014 Sep 3.

PMID:
25187485
6.

Serum concentrations of hydroxybupropion for dose optimization of depressed patients treated with bupropion.

Laib AK, Brünen S, Pfeifer P, Vincent P, Hiemke C.

Ther Drug Monit. 2014 Aug;36(4):473-9. doi: 10.1097/FTD.0000000000000042.

PMID:
24452068
7.

Inhibition of human CYP2B6-catalyzed bupropion hydroxylation by Ginkgo biloba extract: effect of terpene trilactones and flavonols.

Lau AJ, Chang TK.

Drug Metab Dispos. 2009 Sep;37(9):1931-7. doi: 10.1124/dmd.109.028118. Epub 2009 Jun 1.

8.

Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.

Kharasch ED, Mitchell D, Coles R.

J Clin Pharmacol. 2008 Apr;48(4):464-74. doi: 10.1177/0091270008314254. Epub 2008 Feb 20.

PMID:
18287571
9.

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ.

Drug Metab Dispos. 2000 Oct;28(10):1176-83.

10.

Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation.

David SP, Brown RA, Papandonatos GD, Kahler CW, Lloyd-Richardson EE, Munafò MR, Shields PG, Lerman C, Strong D, McCaffery J, Niaura R.

Nicotine Tob Res. 2007 Aug;9(8):821-33. Erratum in: Nicotine Tob Res. 2007 Nov;9(11):1243.

11.

Efavirenz induces CYP2B6-mediated hydroxylation of bupropion in healthy subjects.

Robertson SM, Maldarelli F, Natarajan V, Formentini E, Alfaro RM, Penzak SR.

J Acquir Immune Defic Syndr. 2008 Dec 15;49(5):513-9. doi: 10.1097/QAI.0b013e318183a425.

PMID:
18989234
12.

Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases.

Joy MS, Frye RF, Stubbert K, Brouwer KR, Falk RJ, Kharasch ED.

J Clin Pharmacol. 2010 Jun;50(6):714-20. doi: 10.1177/0091270009353031. Epub 2010 Jan 26. No abstract available.

13.

Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: effect of induction by rifampin and ethnicity.

Loboz KK, Gross AS, Williams KM, Liauw WS, Day RO, Blievernicht JK, Zanger UM, McLachlan AJ.

Clin Pharmacol Ther. 2006 Jul;80(1):75-84.

PMID:
16815319
14.

Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6.

Kirchheiner J, Klein C, Meineke I, Sasse J, Zanger UM, Mürdter TE, Roots I, Brockmöller J.

Pharmacogenetics. 2003 Oct;13(10):619-26.

PMID:
14515060
15.

Effects of sertraline on the pharmacokinetics of bupropion and its major metabolite, hydroxybupropion, in mice.

Molnari JC, Hassan HE, Myers AL.

Eur J Drug Metab Pharmacokinet. 2012 Mar;37(1):57-63. doi: 10.1007/s13318-011-0065-6. Epub 2011 Sep 17.

PMID:
21928040
16.

Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin.

Chung JY, Cho JY, Lim HS, Kim JR, Yu KS, Lim KS, Shin SG, Jang IJ.

Drug Metab Dispos. 2011 Jan;39(1):92-7. doi: 10.1124/dmd.110.035246. Epub 2010 Sep 28.

17.

Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation.

Fan L, Wang JC, Jiang F, Tan ZR, Chen Y, Li Q, Zhang W, Wang G, Lei HP, Hu DL, Wang D, Zhou HH.

Eur J Clin Pharmacol. 2009 Apr;65(4):403-9. doi: 10.1007/s00228-008-0594-3. Epub 2008 Dec 9.

PMID:
19066872
18.

The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans.

Ilic K, Hawke RL, Thirumaran RK, Schuetz EG, Hull JH, Kashuba AD, Stewart PW, Lindley CM, Chen ML.

Drug Metab Dispos. 2013 Mar;41(3):575-81. doi: 10.1124/dmd.112.048108. Epub 2012 Dec 13.

19.

A double-blind, placebo-controlled, randomized trial of bupropion for smoking cessation in primary care.

Fossati R, Apolone G, Negri E, Compagnoni A, La Vecchia C, Mangano S, Clivio L, Garattini S; General Practice Tobacco Cessation Investigators Group.

Arch Intern Med. 2007 Sep 10;167(16):1791-7.

PMID:
17846399
20.

Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men.

Qin WJ, Zhang W, Liu ZQ, Chen XP, Tan ZR, Hu DL, Wang D, Fan L, Zhou HH.

Br J Clin Pharmacol. 2012 Dec;74(6):999-1004. doi: 10.1111/j.1365-2125.2012.04304.x.

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