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Results: 1 to 20 of 105

1.

Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein.

Ochoa MC, Fioravanti J, Rodriguez I, Hervas-Stubbs S, Azpilikueta A, Mazzolini G, Gúrpide A, Prieto J, Pardo J, Berraondo P, Melero I.

Cancer Res. 2013 Jan 1;73(1):139-49. doi: 10.1158/0008-5472.CAN-12-2660. Epub 2012 Nov 13.

PMID:
23149919
[PubMed - indexed for MEDLINE]
Free Article
2.

Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy.

Ochoa MC, Fioravanti J, Duitman EH, Medina-Echeverz J, Palazon A, Arina A, Dubrot J, Alfaro C, Morales-Kastresana A, Murillo O, Hervas-Stubbs S, Prieto J, Berraondo P, Melero I.

PLoS One. 2012;7(12):e52370. doi: 10.1371/journal.pone.0052370. Epub 2012 Dec 21.

PMID:
23285013
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action.

Dubois S, Patel HJ, Zhang M, Waldmann TA, Müller JR.

J Immunol. 2008 Feb 15;180(4):2099-106.

PMID:
18250415
[PubMed - indexed for MEDLINE]
Free Article
4.

IL-15R alpha-IgG1-Fc enhances IL-2 and IL-15 anti-tumor action through NK and CD8+ T cells proliferation and activation.

Wu Z, Xu Y.

J Mol Cell Biol. 2010 Aug;2(4):217-22. doi: 10.1093/jmcb/mjq012.

PMID:
20671116
[PubMed - indexed for MEDLINE]
Free Article
5.

Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice.

Zhang M, Ju W, Yao Z, Yu P, Wei BR, Simpson RM, Waitz R, Fassò M, Allison JP, Waldmann TA.

J Immunol. 2012 Jun 15;188(12):6156-64. doi: 10.4049/jimmunol.1102604. Epub 2012 May 16.

PMID:
22593619
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis.

Burkett PR, Koka R, Chien M, Chai S, Boone DL, Ma A.

J Exp Med. 2004 Oct 4;200(7):825-34. Epub 2004 Sep 27.

PMID:
15452177
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.

Chenoweth MJ, Mian MF, Barra NG, Alain T, Sonenberg N, Bramson J, Lichty BD, Richards CD, Ma A, Ashkar AA.

J Immunol. 2012 May 1;188(9):4149-57. doi: 10.4049/jimmunol.1101883. Epub 2012 Mar 23.

PMID:
22447977
[PubMed - indexed for MEDLINE]
Free Article
8.

Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity.

Søndergaard H, Coquet JM, Uldrich AP, McLaughlin N, Godfrey DI, Sivakumar PV, Skak K, Smyth MJ.

J Immunol. 2009 Dec 1;183(11):7326-36. doi: 10.4049/jimmunol.0902697. Epub 2009 Nov 13.

PMID:
19915059
[PubMed - indexed for MEDLINE]
Free Article
9.

In vivo antitumor activity of interleukin 21 mediated by natural killer cells.

Wang G, Tschoi M, Spolski R, Lou Y, Ozaki K, Feng C, Kim G, Leonard WJ, Hwu P.

Cancer Res. 2003 Dec 15;63(24):9016-22.

PMID:
14695220
[PubMed - indexed for MEDLINE]
Free Article
10.

In vivo expansion of activated naive CD8+ T cells and NK cells driven by complexes of IL-2 and anti-IL-2 monoclonal antibody as novel approach of cancer immunotherapy.

Tomala J, Chmelova H, Mrkvan T, Rihova B, Kovar M.

J Immunol. 2009 Oct 15;183(8):4904-12. doi: 10.4049/jimmunol.0900284.

PMID:
19801515
[PubMed - indexed for MEDLINE]
Free Article
11.

Reduced tumorigenesis of EG7 after interleukin-10 gene transfer and enhanced efficacy in combination with intratumorally injection of adenovirus-mediated lymphotactin and the underlying mechanism.

Zhang J, Zhou Z, Wang C, Shen J, Zheng Y, Zhang L, Wang J, Xia D.

Cancer Immunol Immunother. 2011 Apr;60(4):559-73. doi: 10.1007/s00262-010-0955-5. Epub 2011 Jan 15.

PMID:
21240488
[PubMed - indexed for MEDLINE]
12.

An antibody fusion protein for cancer immunotherapy mimicking IL-15 trans-presentation at the tumor site.

Kermer V, Baum V, Hornig N, Kontermann RE, Müller D.

Mol Cancer Ther. 2012 Jun;11(6):1279-88. doi: 10.1158/1535-7163.MCT-12-0019. Epub 2012 Apr 6.

PMID:
22491823
[PubMed - indexed for MEDLINE]
Free Article
13.

Recombinant human prolactin improves antitumor effects of murine natural killer cells in vitro and in vivo.

Sun R, Wei H, Zhang J, Li A, Zhang W, Tian Z.

Neuroimmunomodulation. 2002-2003;10(3):169-76.

PMID:
12481157
[PubMed - indexed for MEDLINE]
14.

IL-15: targeting CD8+ T cells for immunotherapy.

Diab A, Cohen AD, Alpdogan O, Perales MA.

Cytotherapy. 2005;7(1):23-35. Review.

PMID:
16040381
[PubMed - indexed for MEDLINE]
15.

The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation.

Wu Z, Xue HH, Bernard J, Zeng R, Issakov D, Bollenbacher-Reilley J, Belyakov IM, Oh S, Berzofsky JA, Leonard WJ.

Blood. 2008 Dec 1;112(12):4411-9. doi: 10.1182/blood-2007-03-080697. Epub 2008 Sep 16.

PMID:
18796634
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo.

Stoklasek TA, Schluns KS, Lefrançois L.

J Immunol. 2006 Nov 1;177(9):6072-80.

PMID:
17056533
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Different dynamics of IL-15R activation following IL-15 cis- or trans-presentation.

Perdreau H, Mortier E, Bouchaud G, Solé V, Boublik Y, Plet A, Jacques Y.

Eur Cytokine Netw. 2010 Dec;21(4):297-307. doi: 10.1684/ecn.2010.0207. Epub 2010 Nov 16.

PMID:
21078585
[PubMed - indexed for MEDLINE]
18.

Treatment of hepatocellular carcinoma with adeno-associated virus encoding interleukin-15 superagonist.

Chang CM, Lo CH, Shih YM, Chen Y, Wu PY, Tsuneyama K, Roffler SR, Tao MH.

Hum Gene Ther. 2010 May;21(5):611-21. doi: 10.1089/hum.2009.187.

PMID:
20064014
[PubMed - indexed for MEDLINE]
19.

High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor alpha fusion protein, in metastatic melanoma and colorectal cancer.

Bessard A, Solé V, Bouchaud G, Quéméner A, Jacques Y.

Mol Cancer Ther. 2009 Sep;8(9):2736-45. doi: 10.1158/1535-7163.MCT-09-0275. Epub 2009 Sep 1.

PMID:
19723883
[PubMed - indexed for MEDLINE]
Free Article
20.

Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes.

Elpek KG, Rubinstein MP, Bellemare-Pelletier A, Goldrath AW, Turley SJ.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21647-52. doi: 10.1073/pnas.1012128107. Epub 2010 Nov 22.

PMID:
21098276
[PubMed - indexed for MEDLINE]
Free PMC Article

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