Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 113

1.

Evaluation of combination therapy schedules of doxorubicin and an acid-sensitive albumin-binding prodrug of doxorubicin in the MIA PaCa-2 pancreatic xenograft model.

Kratz F, Azab S, Zeisig R, Fichtner I, Warnecke A.

Int J Pharm. 2013 Jan 30;441(1-2):499-506. doi: 10.1016/j.ijpharm.2012.11.003. Epub 2012 Nov 10.

PMID:
23149257
[PubMed - indexed for MEDLINE]
2.
3.

DOXO-EMCH (INNO-206): the first albumin-binding prodrug of doxorubicin to enter clinical trials.

Kratz F.

Expert Opin Investig Drugs. 2007 Jun;16(6):855-66. Review.

PMID:
17501697
[PubMed - indexed for MEDLINE]
4.

The 6-maleimidocaproyl hydrazone derivative of doxorubicin (DOXO-EMCH) is superior to free doxorubicin with respect to cardiotoxicity and mitochondrial damage.

Lebrecht D, Geist A, Ketelsen UP, Haberstroh J, Setzer B, Kratz F, Walker UA.

Int J Cancer. 2007 Feb 15;120(4):927-34.

PMID:
17131338
[PubMed - indexed for MEDLINE]
5.

Phase I and pharmacokinetic study of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin.

Unger C, Häring B, Medinger M, Drevs J, Steinbild S, Kratz F, Mross K.

Clin Cancer Res. 2007 Aug 15;13(16):4858-66.

PMID:
17699865
[PubMed - indexed for MEDLINE]
Free Article
6.

Characterisation of the conjugate of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin with lactosaminated human albumin by 13C NMR spectroscopy.

Boga C, Fiume L, Baglioni M, Bertucci C, Farina C, Kratz F, Manerba M, Naldi M, Di Stefano G.

Eur J Pharm Sci. 2009 Oct 8;38(3):262-9. doi: 10.1016/j.ejps.2009.08.001. Epub 2009 Aug 18.

PMID:
19695327
[PubMed - indexed for MEDLINE]
7.

Zosuquidar and an albumin-binding prodrug of zosuquidar reverse multidrug resistance in breast cancer cells of doxorubicin and an albumin-binding prodrug of doxorubicin.

Abu Ajaj K, Graeser R, Kratz F.

Breast Cancer Res Treat. 2012 Jul;134(1):117-29. doi: 10.1007/s10549-011-1937-9. Epub 2012 Jan 8.

PMID:
22228402
[PubMed - indexed for MEDLINE]
8.

Synthesis and biological evaluation of an albumin-binding prodrug of doxorubicin that is cleaved by prostate-specific antigen (PSA) in a PSA-positive orthotopic prostate carcinoma model (LNCaP).

Graeser R, Chung DE, Esser N, Moor S, Schächtele C, Unger C, Kratz F.

Int J Cancer. 2008 Mar 1;122(5):1145-54.

PMID:
17973264
[PubMed - indexed for MEDLINE]
9.

Development of albumin-binding doxorubicin prodrugs that are cleaved by prostate-specific antigen.

Kratz F, Mansour A, Soltau J, Warnecke A, Fichtner I, Unger C, Drevs J.

Arch Pharm (Weinheim). 2005 Oct;338(10):462-72.

PMID:
16211657
[PubMed - indexed for MEDLINE]
10.

Combination therapy with the albumin-binding prodrug of doxorubicin (INNO-206) and doxorubicin achieves complete remissions and improves tolerability in an ovarian A2780 xenograft model.

Kratz F, Fichtner I, Graeser R.

Invest New Drugs. 2012 Aug;30(4):1743-9. doi: 10.1007/s10637-011-9686-5. Epub 2011 May 18. No abstract available.

PMID:
21590366
[PubMed - indexed for MEDLINE]
11.

Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy.

Schmid B, Chung DE, Warnecke A, Fichtner I, Kratz F.

Bioconjug Chem. 2007 May-Jun;18(3):702-16. Epub 2007 Mar 23.

PMID:
17378599
[PubMed - indexed for MEDLINE]
12.

INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model.

Graeser R, Esser N, Unger H, Fichtner I, Zhu A, Unger C, Kratz F.

Invest New Drugs. 2010 Feb;28(1):14-9. doi: 10.1007/s10637-008-9208-2. Epub 2009 Jan 8.

PMID:
19148580
[PubMed - indexed for MEDLINE]
13.

Probing the cysteine-34 position of endogenous serum albumin with thiol-binding doxorubicin derivatives. Improved efficacy of an acid-sensitive doxorubicin derivative with specific albumin-binding properties compared to that of the parent compound.

Kratz F, Warnecke A, Scheuermann K, Stockmar C, Schwab J, Lazar P, Drückes P, Esser N, Drevs J, Rognan D, Bissantz C, Hinderling C, Folkers G, Fichtner I, Unger C.

J Med Chem. 2002 Dec 5;45(25):5523-33.

PMID:
12459020
[PubMed - indexed for MEDLINE]
14.

Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.

Houba PH, Boven E, van der Meulen-Muileman IH, Leenders RG, Scheeren JW, Pinedo HM, Haisma HJ.

Int J Cancer. 2001 Feb 15;91(4):550-4.

PMID:
11251980
[PubMed - indexed for MEDLINE]
15.

Synergistic activity of troxacitabine (Troxatyl) and gemcitabine in pancreatic cancer.

Damaraju VL, Bouffard DY, Wong CK, Clarke ML, Mackey JR, Leblond L, Cass CE, Grey M, Gourdeau H.

BMC Cancer. 2007 Jul 3;7:121.

PMID:
17608948
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Cell penetrating peptides fused to a thermally targeted biopolymer drug carrier improve the delivery and antitumor efficacy of an acid-sensitive doxorubicin derivative.

Walker L, Perkins E, Kratz F, Raucher D.

Int J Pharm. 2012 Oct 15;436(1-2):825-32. doi: 10.1016/j.ijpharm.2012.07.043. Epub 2012 Jul 28.

PMID:
22850291
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer.

Ottewell PD, Mönkkönen H, Jones M, Lefley DV, Coleman RE, Holen I.

J Natl Cancer Inst. 2008 Aug 20;100(16):1167-78. doi: 10.1093/jnci/djn240. Epub 2008 Aug 11.

PMID:
18695136
[PubMed - indexed for MEDLINE]
Free Article
18.
19.

The synthesis of a prodrug of doxorubicin designed to provide reduced systemic toxicity and greater target efficacy.

Garsky VM, Lumma PK, Feng DM, Wai J, Ramjit HG, Sardana MK, Oliff A, Jones RE, DeFeo-Jones D, Freidinger RM.

J Med Chem. 2001 Nov 22;44(24):4216-24.

PMID:
11708923
[PubMed - indexed for MEDLINE]
20.

Anti-myeloma effects of the novel anthracycline derivative INNO-206.

Sanchez E, Li M, Wang C, Nichols CM, Li J, Chen H, Berenson JR.

Clin Cancer Res. 2012 Jul 15;18(14):3856-67. doi: 10.1158/1078-0432.CCR-11-3130. Epub 2012 May 22.

PMID:
22619306
[PubMed - indexed for MEDLINE]
Free Article
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk