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Results: 1 to 20 of 406

1.

Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells.

Fafilek B, Krausova M, Vojtechova M, Pospichalova V, Tumova L, Sloncova E, Huranova M, Stancikova J, Hlavata A, Svec J, Sedlacek R, Luksan O, Oliverius M, Voska L, Jirsa M, Paces J, Kolar M, Krivjanska M, Klimesova K, Tlaskalova-Hogenova H, Korinek V.

Gastroenterology. 2013 Feb;144(2):381-91. doi: 10.1053/j.gastro.2012.10.048. Epub 2012 Nov 7.

PMID:
23142137
[PubMed - indexed for MEDLINE]
2.

Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling.

Nik AM, Reyahi A, Pontén F, Carlsson P.

Gastroenterology. 2013 May;144(5):1001-11. doi: 10.1053/j.gastro.2013.01.045. Epub 2013 Jan 31.

PMID:
23376422
[PubMed - indexed for MEDLINE]
3.

The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling.

Chen HZ, Liu QF, Li L, Wang WJ, Yao LM, Yang M, Liu B, Chen W, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA, Wu Q.

Gut. 2012 May;61(5):714-24. doi: 10.1136/gutjnl-2011-300783. Epub 2011 Aug 28.

PMID:
21873734
[PubMed - indexed for MEDLINE]
4.

BCL9-2 promotes early stages of intestinal tumor progression.

Brembeck FH, Wiese M, Zatula N, Grigoryan T, Dai Y, Fritzmann J, Birchmeier W.

Gastroenterology. 2011 Oct;141(4):1359-70, 1370.e1-3. doi: 10.1053/j.gastro.2011.06.039. Epub 2011 Jun 23.

PMID:
21703997
[PubMed - indexed for MEDLINE]
5.

Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells.

Kemper K, Prasetyanti PR, De Lau W, Rodermond H, Clevers H, Medema JP.

Stem Cells. 2012 Nov;30(11):2378-86. doi: 10.1002/stem.1233.

PMID:
22969042
[PubMed - indexed for MEDLINE]
Free Article
6.

Wnt signaling in adult intestinal stem cells and cancer.

Krausova M, Korinek V.

Cell Signal. 2014 Mar;26(3):570-9. doi: 10.1016/j.cellsig.2013.11.032. Epub 2013 Dec 2. Review.

PMID:
24308963
[PubMed - indexed for MEDLINE]
Free Article
7.

Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis.

Zeilstra J, Joosten SP, Dokter M, Verwiel E, Spaargaren M, Pals ST.

Cancer Res. 2008 May 15;68(10):3655-61. doi: 10.1158/0008-5472.CAN-07-2940.

PMID:
18483247
[PubMed - indexed for MEDLINE]
Free Article
8.

LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines.

Walker F, Zhang HH, Odorizzi A, Burgess AW.

PLoS One. 2011;6(7):e22733. doi: 10.1371/journal.pone.0022733. Epub 2011 Jul 28.

PMID:
21829496
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Genetic reconstitution of tumorigenesis in primary intestinal cells.

Onuma K, Ochiai M, Orihashi K, Takahashi M, Imai T, Nakagama H, Hippo Y.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11127-32. doi: 10.1073/pnas.1221926110. Epub 2013 Jun 17.

PMID:
23776211
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

LGR5 positivity defines stem-like cells in colorectal cancer.

Hirsch D, Barker N, McNeil N, Hu Y, Camps J, McKinnon K, Clevers H, Ried T, Gaiser T.

Carcinogenesis. 2014 Apr;35(4):849-58. doi: 10.1093/carcin/bgt377. Epub 2013 Nov 26.

PMID:
24282287
[PubMed - indexed for MEDLINE]
11.

HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression.

Li Y, Bavarva JH, Wang Z, Guo J, Qian C, Thibodeau SN, Golemis EA, Liu W.

Oncogene. 2011 Jun 9;30(23):2633-43. doi: 10.1038/onc.2010.632. Epub 2011 Feb 14.

PMID:
21317929
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signaling.

Bonnans C, Flacelière M, Grillet F, Dantec C, Desvignes JP, Pannequin J, Severac D, Dubois E, Bibeau F, Escriou V, Crespy P, Journot L, Hollande F, Joubert D.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3047-52. doi: 10.1073/pnas.1109457109. Epub 2012 Feb 6.

PMID:
22315403
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs.

Al-Kharusi MR, Smartt HJ, Greenhough A, Collard TJ, Emery ED, Williams AC, Paraskeva C.

Carcinogenesis. 2013 May;34(5):1150-7. doi: 10.1093/carcin/bgt020. Epub 2013 Jan 24.

PMID:
23349017
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression.

Janssen KP, Alberici P, Fsihi H, Gaspar C, Breukel C, Franken P, Rosty C, Abal M, El Marjou F, Smits R, Louvard D, Fodde R, Robine S.

Gastroenterology. 2006 Oct;131(4):1096-109. Epub 2006 Aug 16. Erratum in: Gastroenterology. 2006 Dec;131(6):2029.

PMID:
17030180
[PubMed - indexed for MEDLINE]
15.

[Plasticity of WNT signaling activity in colorectal cancer].

Horst D.

Pathologe. 2012 Nov;33 Suppl 2:194-7. doi: 10.1007/s00292-012-1660-2. Review. German.

PMID:
22968731
[PubMed - indexed for MEDLINE]
16.

Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer.

Uchida H, Yamazaki K, Fukuma M, Yamada T, Hayashida T, Hasegawa H, Kitajima M, Kitagawa Y, Sakamoto M.

Cancer Sci. 2010 Jul;101(7):1731-7. doi: 10.1111/j.1349-7006.2010.01571.x. Epub 2010 Mar 24. Erratum in: Cancer Sci. 2010 Jul;101(7):1767.

PMID:
20384634
[PubMed - indexed for MEDLINE]
17.

Constitutive TLR4 signalling in intestinal epithelium reduces tumor load by increasing apoptosis in APC(Min/+) mice.

Li Y, Teo WL, Low MJ, Meijer L, Sanderson I, Pettersson S, Greicius G.

Oncogene. 2014 Jan 16;33(3):369-77. doi: 10.1038/onc.2012.581. Epub 2013 Jan 14.

PMID:
23318418
[PubMed - indexed for MEDLINE]
18.

Myb controls intestinal stem cell genes and self-renewal.

Cheasley D, Pereira L, Lightowler S, Vincan E, Malaterre J, Ramsay RG.

Stem Cells. 2011 Dec;29(12):2042-50. doi: 10.1002/stem.761.

PMID:
21997934
[PubMed - indexed for MEDLINE]
Free Article
19.

Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.

Lewis A, Segditsas S, Deheragoda M, Pollard P, Jeffery R, Nye E, Lockstone H, Davis H, Clark S, Stamp G, Poulsom R, Wright N, Tomlinson I.

Gut. 2010 Dec;59(12):1680-6. doi: 10.1136/gut.2009.193680. Epub 2010 Oct 6.

PMID:
20926645
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The Intestinal Wnt/TCF Signature.

Van der Flier LG, Sabates-Bellver J, Oving I, Haegebarth A, De Palo M, Anti M, Van Gijn ME, Suijkerbuijk S, Van de Wetering M, Marra G, Clevers H.

Gastroenterology. 2007 Feb;132(2):628-32. Epub 2006 Aug 18.

PMID:
17320548
[PubMed - indexed for MEDLINE]
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