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Re: VHL-Regulated miR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma.

Atala A.

J Urol. 2012 Dec;188(6):2434. doi: 10.1016/j.juro.2012.08.067. Epub 2012 Oct 22. No abstract available.


Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.

Smith K, Gunaratnam L, Morley M, Franovic A, Mekhail K, Lee S.

Cancer Res. 2005 Jun 15;65(12):5221-30.


The von Hippel-Lindau tumor suppressor gene and kidney cancer.

Kaelin WG Jr.

Clin Cancer Res. 2004 Sep 15;10(18 Pt 2):6290S-5S. Review.


Vascular endothelial growth factor-B and vascular endothelial growth factor-C expression in renal cell carcinomas: regulation by the von Hippel-Lindau gene and hypoxia.

Gunningham SP, Currie MJ, Han C, Turner K, Scott PA, Robinson BA, Harris AL, Fox SB.

Cancer Res. 2001 Apr 1;61(7):3206-11.


Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.

de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause A, Lee S.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1387-92. Epub 2001 Feb 6.


A transcriptional variant of the LC3A gene is involved in autophagy and frequently inactivated in human cancers.

Bai H, Inoue J, Kawano T, Inazawa J.

Oncogene. 2012 Oct 4;31(40):4397-408. doi: 10.1038/onc.2011.613. Epub 2012 Jan 16.


The miR-17-92 cluster is over expressed in and has an oncogenic effect on renal cell carcinoma.

Chow TF, Mankaruos M, Scorilas A, Youssef Y, Girgis A, Mossad S, Metias S, Rofael Y, Honey RJ, Stewart R, Pace KT, Yousef GM.

J Urol. 2010 Feb;183(2):743-51. doi: 10.1016/j.juro.2009.09.086.


JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma.

Kanno T, Kamba T, Yamasaki T, Shibasaki N, Saito R, Terada N, Toda Y, Mikami Y, Inoue T, Kanematsu A, Nishiyama H, Ogawa O, Nakamura E.

Oncogene. 2012 Jun 21;31(25):3098-110. doi: 10.1038/onc.2011.475. Epub 2011 Oct 24.


Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene.

Chen F, Kishida T, Duh FM, Renbaum P, Orcutt ML, Schmidt L, Zbar B.

Cancer Res. 1995 Nov 1;55(21):4804-7.


Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma.

Perier A, Fregni G, Wittnebel S, Gad S, Allard M, Gervois N, Escudier B, Azzarone B, Caignard A.

Oncogene. 2011 Jun 9;30(23):2622-32. doi: 10.1038/onc.2010.638. Epub 2011 Jan 24.


Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia.

Schraml P, Frew IJ, Thoma CR, Boysen G, Struckmann K, Krek W, Moch H.

Mod Pathol. 2009 Jan;22(1):31-6. doi: 10.1038/modpathol.2008.132. Epub 2008 Jul 25.


Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins.

Rohan SM, Xiao Y, Liang Y, Dudas ME, Al-Ahmadie HA, Fine SW, Gopalan A, Reuter VE, Rosenblum MK, Russo P, Tickoo SK.

Mod Pathol. 2011 Sep;24(9):1207-20. doi: 10.1038/modpathol.2011.80. Epub 2011 May 20.


Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells.

Sutphin PD, Chan DA, Li JM, Turcotte S, Krieg AJ, Giaccia AJ.

Cancer Res. 2007 Jun 15;67(12):5896-905.


Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein.

Esteban MA, Harten SK, Tran MG, Maxwell PH.

J Am Soc Nephrol. 2006 Jul;17(7):1801-6. Epub 2006 Jun 14.


Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells.

Gunaratnam L, Morley M, Franovic A, de Paulsen N, Mekhail K, Parolin DA, Nakamura E, Lorimer IA, Lee S.

J Biol Chem. 2003 Nov 7;278(45):44966-74. Epub 2003 Aug 27.

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