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Results: 1 to 20 of 86

1.

Role of C-terminal negative charges and tyrosine residues in fibril formation of α-synuclein.

Izawa Y, Tateno H, Kameda H, Hirakawa K, Hato K, Yagi H, Hongo K, Mizobata T, Kawata Y.

Brain Behav. 2012 Sep;2(5):595-605. doi: 10.1002/brb3.86. Epub 2012 Aug 10.

PMID:
23139905
[PubMed]
Free PMC Article
2.

Impact of Tyr to Ala mutations on alpha-synuclein fibrillation and structural properties.

Ulrih NP, Barry CH, Fink AL.

Biochim Biophys Acta. 2008 Oct;1782(10):581-5. doi: 10.1016/j.bbadis.2008.07.004. Epub 2008 Jul 22.

PMID:
18692132
[PubMed - indexed for MEDLINE]
Free Article
3.

Engineered alpha-synuclein prevents wild type and familial Parkin variant fibril formation.

Sode K, Usuzaka E, Kobayashi N, Ochiai S.

Biochem Biophys Res Commun. 2005 Sep 23;335(2):432-6.

PMID:
16081040
[PubMed - indexed for MEDLINE]
4.

Mechanistic insight into the relationship between N-terminal acetylation of α-synuclein and fibril formation rates by NMR and fluorescence.

Kang L, Janowska MK, Moriarty GM, Baum J.

PLoS One. 2013 Sep 18;8(9):e75018. doi: 10.1371/journal.pone.0075018. eCollection 2013.

PMID:
24058647
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The E46K mutation in alpha-synuclein increases amyloid fibril formation.

Greenbaum EA, Graves CL, Mishizen-Eberz AJ, Lupoli MA, Lynch DR, Englander SW, Axelsen PH, Giasson BI.

J Biol Chem. 2005 Mar 4;280(9):7800-7. Epub 2005 Jan 4.

PMID:
15632170
[PubMed - indexed for MEDLINE]
Free Article
6.

Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro.

Cohlberg JA, Li J, Uversky VN, Fink AL.

Biochemistry. 2002 Feb 5;41(5):1502-11.

PMID:
11814343
[PubMed - indexed for MEDLINE]
7.

Sequence determinants regulating fibrillation of human alpha-synuclein.

Koo HJ, Lee HJ, Im H.

Biochem Biophys Res Commun. 2008 Apr 11;368(3):772-8. doi: 10.1016/j.bbrc.2008.01.140. Epub 2008 Feb 7.

PMID:
18261982
[PubMed - indexed for MEDLINE]
8.

Isolation of short peptide fragments from alpha-synuclein fibril core identifies a residue important for fibril nucleation: a possible implication for diagnostic applications.

Yagi H, Takeuchi H, Ogawa S, Ito N, Sakane I, Hongo K, Mizobata T, Goto Y, Kawata Y.

Biochim Biophys Acta. 2010 Oct;1804(10):2077-87. doi: 10.1016/j.bbapap.2010.07.007. Epub 2010 Jul 13.

PMID:
20637318
[PubMed - indexed for MEDLINE]
9.

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.

Conway KA, Harper JD, Lansbury PT Jr.

Biochemistry. 2000 Mar 14;39(10):2552-63.

PMID:
10704204
[PubMed - indexed for MEDLINE]
10.

Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity.

Rekas A, Adda CG, Andrew Aquilina J, Barnham KJ, Sunde M, Galatis D, Williamson NA, Masters CL, Anders RF, Robinson CV, Cappai R, Carver JA.

J Mol Biol. 2004 Jul 23;340(5):1167-83.

PMID:
15236975
[PubMed - indexed for MEDLINE]
11.

Aggregation-defective alpha-synuclein mutants inhibit the fibrillation of Parkinson's disease-linked alpha-synuclein variants.

Koo HJ, Choi MY, Im H.

Biochem Biophys Res Commun. 2009 Aug 14;386(1):165-9. doi: 10.1016/j.bbrc.2009.06.002. Epub 2009 Jun 6.

PMID:
19501571
[PubMed - indexed for MEDLINE]
12.

The conformation and the aggregation kinetics of α-synuclein depend on the proline residues in its C-terminal region.

Meuvis J, Gerard M, Desender L, Baekelandt V, Engelborghs Y.

Biochemistry. 2010 Nov 2;49(43):9345-52. doi: 10.1021/bi1010927.

PMID:
20828147
[PubMed - indexed for MEDLINE]
13.

The inhibitory effect of pyrroloquinoline quinone on the amyloid formation and cytotoxicity of truncated alpha-synuclein.

Kim J, Harada R, Kobayashi M, Kobayashi N, Sode K.

Mol Neurodegener. 2010 May 20;5:20. doi: 10.1186/1750-1326-5-20.

PMID:
20482893
[PubMed]
Free PMC Article
14.

Investigation of alpha-synuclein fibril structure by site-directed spin labeling.

Chen M, Margittai M, Chen J, Langen R.

J Biol Chem. 2007 Aug 24;282(34):24970-9. Epub 2007 Jun 15.

PMID:
17573347
[PubMed - indexed for MEDLINE]
Free Article
15.

Role of different regions of alpha-synuclein in the assembly of fibrils.

Qin Z, Hu D, Han S, Hong DP, Fink AL.

Biochemistry. 2007 Nov 20;46(46):13322-30. Epub 2007 Oct 27.

PMID:
17963364
[PubMed - indexed for MEDLINE]
16.

Identification of the region responsible for fibril formation in the CAD domain of caspase-activated DNase.

Nakamura T, Kobayashi A, Hagihara Y, Takai T, Mine S, Yamazaki T, Yumoto N, Uegaki K.

J Biochem. 2005 Dec;138(6):815-9.

PMID:
16428311
[PubMed - indexed for MEDLINE]
17.

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro.

Murray IV, Giasson BI, Quinn SM, Koppaka V, Axelsen PH, Ischiropoulos H, Trojanowski JQ, Lee VM.

Biochemistry. 2003 Jul 22;42(28):8530-40.

PMID:
12859200
[PubMed - indexed for MEDLINE]
18.

Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization.

Waxman EA, Mazzulli JR, Giasson BI.

Biochemistry. 2009 Oct 13;48(40):9427-36. doi: 10.1021/bi900539p.

PMID:
19722699
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Amyloid fibril formation of alpha-synuclein is accelerated by preformed amyloid seeds of other proteins: implications for the mechanism of transmissible conformational diseases.

Yagi H, Kusaka E, Hongo K, Mizobata T, Kawata Y.

J Biol Chem. 2005 Nov 18;280(46):38609-16. Epub 2005 Sep 14.

PMID:
16162499
[PubMed - indexed for MEDLINE]
Free Article
20.

Granular assembly of alpha-synuclein leading to the accelerated amyloid fibril formation with shear stress.

Bhak G, Lee JH, Hahn JS, Paik SR.

PLoS One. 2009;4(1):e4177. doi: 10.1371/journal.pone.0004177. Epub 2009 Jan 12.

PMID:
19137068
[PubMed - indexed for MEDLINE]
Free PMC Article

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