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Results: 1 to 20 of 97

1.

Integrated compound profiling screens identify the mitochondrial electron transport chain as the molecular target of the natural products manassantin, sesquicillin, and arctigenin.

Lai K, Selinger DW, Solomon JM, Wu H, Schmitt E, Serluca FC, Curtis D, Benson JD.

ACS Chem Biol. 2013 Jan 18;8(1):257-67. doi: 10.1021/cb300495e. Epub 2012 Nov 8.

PMID:
23138533
[PubMed - indexed for MEDLINE]
2.

Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.

Thomas S, Sharma N, Gonzalez R, Pao PW, Hofman FM, Chen TC, Louie SG, Pirrung MC, Schönthal AH.

PLoS One. 2013 Jun 6;8(6):e65695. doi: 10.1371/journal.pone.0065695. Print 2013.

PMID:
23755268
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway.

Zhao F, Wang L, Liu K.

J Ethnopharmacol. 2009 Apr 21;122(3):457-62. doi: 10.1016/j.jep.2009.01.038. Epub 2009 Feb 20.

PMID:
19429312
[PubMed - indexed for MEDLINE]
4.

Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice.

Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, Hu YH, Tao YD, Leng Y.

Diabetologia. 2012 May;55(5):1469-81. doi: 10.1007/s00125-011-2366-3. Epub 2011 Nov 18.

PMID:
22095235
[PubMed - indexed for MEDLINE]
5.

Molecular-targeted antitumor agents: the Saururus cernuus dineolignans manassantin B and 4-O-demethylmanassantin B are potent inhibitors of hypoxia-activated HIF-1.

Hodges TW, Hossain CF, Kim YP, Zhou YD, Nagle DG.

J Nat Prod. 2004 May;67(5):767-71.

PMID:
15165135
[PubMed - indexed for MEDLINE]
6.

Development of an assay for Complex I/Complex III of the respiratory chain using solid supported membranes and its application in mitochondrial toxicity screening in drug discovery.

Preissl S, Bick I, Obrdlik P, Diekert K, Gul S, Gribbon P.

Assay Drug Dev Technol. 2011 Apr;9(2):147-56. doi: 10.1089/adt.2010.0320. Epub 2010 Dec 6.

PMID:
21133681
[PubMed - indexed for MEDLINE]
7.

Phytochemical profile and apoptotic activity of Onopordum cynarocephalum.

Formisano C, Rigano D, Russo A, Cardile V, Caggia S, Apostolides Arnold N, Mari A, Piacente S, Rosselli S, Senatore F, Bruno M.

Planta Med. 2012 Oct;78(15):1651-60. doi: 10.1055/s-0032-1315259. Epub 2012 Sep 10.

PMID:
22965548
[PubMed - indexed for MEDLINE]
8.

Functional prediction and physiological characterization of a novel short trans-membrane protein 1 as a subunit of mitochondrial respiratory complexes.

Zhang D, Xi Y, Coccimiglio ML, Mennigen JA, Jonz MG, Ekker M, Trudeau VL.

Physiol Genomics. 2012 Dec 1;44(23):1133-40. doi: 10.1152/physiolgenomics.00079.2012. Epub 2012 Oct 16.

PMID:
23073385
[PubMed - indexed for MEDLINE]
Free Article
9.

Lignans inhibit cell growth via regulation of Wnt/beta-catenin signaling.

Yoo JH, Lee HJ, Kang K, Jho EH, Kim CY, Baturen D, Tunsag J, Nho CW.

Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2247-52. doi: 10.1016/j.fct.2010.05.056. Epub 2010 May 25.

PMID:
20510325
[PubMed - indexed for MEDLINE]
10.

Radical carboxyarylation approach to lignans. Total synthesis of (-)-arctigenin, (-)-matairesinol, and related natural products.

Fischer J, Reynolds AJ, Sharp LA, Sherburn MS.

Org Lett. 2004 Apr 29;6(9):1345-8.

PMID:
15101738
[PubMed - indexed for MEDLINE]
11.

Suppression of RelA/p65 transactivation activity by a lignoid manassantin isolated from Saururus chinensis.

Lee JH, Hwang BY, Kim KS, Nam JB, Hong YS, Lee JJ.

Biochem Pharmacol. 2003 Nov 15;66(10):1925-33.

PMID:
14599550
[PubMed - indexed for MEDLINE]
12.

Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells.

Sun S, Wang X, Wang C, Nawaz A, Wei W, Li J, Wang L, Yu DH.

Planta Med. 2011 Jan;77(2):141-5. doi: 10.1055/s-0030-1250179. Epub 2010 Aug 17.

PMID:
20717870
[PubMed - indexed for MEDLINE]
13.

Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis.

Lee WS, Lee DW, Baek YI, An S, Cho KH, Choi YK, Kim HC, Park HY, Bae KH, Jeong TS.

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3109-12. Erratum in: Bioorg Med Chem Lett. 2009 Mar 15;19(6):1836. An, So-Jin [corrected to An, Sojin].

PMID:
15149654
[PubMed - indexed for MEDLINE]
14.

Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK.

Shen S, Zhuang J, Chen Y, Lei M, Chen J, Shen X, Hu L.

Bioorg Med Chem. 2013 Jul 1;21(13):3882-93. doi: 10.1016/j.bmc.2013.04.010. Epub 2013 Apr 18.

PMID:
23673223
[PubMed - indexed for MEDLINE]
Free Article
15.

New expectations from the well-known medicinal properties of Arctium lappa.

Miele C, Beguinot F.

Diabetologia. 2012 May;55(5):1244-6. doi: 10.1007/s00125-012-2503-7. Epub 2012 Feb 23.

PMID:
22358500
[PubMed - indexed for MEDLINE]
16.

Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism.

Gu Y, Qi C, Sun X, Ma X, Zhang H, Hu L, Yuan J, Yu Q.

Biochem Pharmacol. 2012 Aug 15;84(4):468-76. doi: 10.1016/j.bcp.2012.06.002. Epub 2012 Jun 9.

PMID:
22687625
[PubMed - indexed for MEDLINE]
17.

Synthesis of (-)-arctigenin derivatives and their anticancer activity.

Gui-Rong C, Li-Ping C, De-Qiang D, Ting-Guo K, Hong-Fu L, Fu-Rui L, Ning J.

Nat Prod Res. 2012;26(2):177-81. doi: 10.1080/14786419.2010.541874. Epub 2011 Aug 26.

PMID:
21867457
[PubMed - indexed for MEDLINE]
18.

[Recent progresses in studies on bioactive lignans from plants].

Zhang GL, Li N, Lin LL, Wang MW.

Zhongguo Zhong Yao Za Zhi. 2007 Oct;32(20):2089-94. Review. Chinese.

PMID:
18306734
[PubMed - indexed for MEDLINE]
19.

Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway.

Kou X, Qi S, Dai W, Luo L, Yin Z.

Int Immunopharmacol. 2011 Aug;11(8):1095-102. doi: 10.1016/j.intimp.2011.03.005. Epub 2011 Mar 21.

PMID:
21426947
[PubMed - indexed for MEDLINE]
20.

Identification of a novel retinoid by small molecule screening with zebrafish embryos.

Sachidanandan C, Yeh JR, Peterson QP, Peterson RT.

PLoS One. 2008 Apr 9;3(4):e1947. doi: 10.1371/journal.pone.0001947.

PMID:
18398471
[PubMed - indexed for MEDLINE]
Free PMC Article

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