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Results: 1 to 20 of 328

1.

A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic mice.

Yang SG, Wang SW, Zhao M, Zhang R, Zhou WW, Li YN, Su YJ, Zhang H, Yu XL, Liu RT.

PLoS One. 2012;7(11):e48540. doi: 10.1371/journal.pone.0048540. Epub 2012 Nov 1.

PMID:
23133641
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.

Kimura R, Devi L, Ohno M.

J Neurochem. 2010 Apr;113(1):248-61. doi: 10.1111/j.1471-4159.2010.06608.x. Epub 2010 Jan 20.

PMID:
20089133
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

[Effects of huannao yicong recipe extract on the learning and memory and related factors of Abeta generation in the brain of APP transgenic mice].

Li H, Liu MF, Liu JG, Liu LT, Guan J, Cai LL, Hu J, Wei Y.

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Jan;33(1):90-4. Chinese.

PMID:
23596795
[PubMed - indexed for MEDLINE]
4.

A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis.

Xue D, Zhao M, Wang YJ, Wang L, Yang Y, Wang SW, Zhang R, Zhao Y, Liu RT.

Neurobiol Dis. 2012 Jun;46(3):701-9. doi: 10.1016/j.nbd.2012.03.013. Epub 2012 Mar 9.

PMID:
22426388
[PubMed - indexed for MEDLINE]
5.

Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice.

Devi L, Ohno M.

Eur J Neurosci. 2010 Jan;31(1):110-8. doi: 10.1111/j.1460-9568.2009.07031.x. Epub 2009 Dec 21.

PMID:
20092558
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.

Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E.

J Neurosci Res. 2006 May 15;83(7):1252-61.

PMID:
16511867
[PubMed - indexed for MEDLINE]
7.

FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation.

Bao XQ, Li N, Wang T, Kong XC, Tai WJ, Sun H, Zhang D.

PLoS One. 2013 Nov 4;8(11):e78033. doi: 10.1371/journal.pone.0078033. eCollection 2013.

PMID:
24223757
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.

McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S.

J Biol Chem. 2007 Sep 7;282(36):26326-34. Epub 2007 Jul 6.

PMID:
17616527
[PubMed - indexed for MEDLINE]
Free Article
9.

Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.

Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG.

J Biol Chem. 2010 Sep 3;285(36):27737-44. doi: 10.1074/jbc.M110.117960. Epub 2010 Jul 1.

PMID:
20595388
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
[PubMed - indexed for MEDLINE]
11.

The beta-secretase, BACE: a prime drug target for Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2001 Oct;17(2):157-70. Review.

PMID:
11816789
[PubMed - indexed for MEDLINE]
12.

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF.

Eur J Neurosci. 2006 Jan;23(1):251-60.

PMID:
16420434
[PubMed - indexed for MEDLINE]
13.

The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis.

Zhao J, O'Connor T, Vassar R.

J Neuroinflammation. 2011 Nov 2;8:150. doi: 10.1186/1742-2094-8-150.

PMID:
22047170
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.

Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G.

J Biol Chem. 2011 Jul 22;286(29):26166-77. doi: 10.1074/jbc.M111.260471. Epub 2011 Jun 3.

PMID:
21642424
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model.

Durairajan SS, Liu LF, Lu JH, Chen LL, Yuan Q, Chung SK, Huang L, Li XS, Huang JD, Li M.

Neurobiol Aging. 2012 Dec;33(12):2903-19. doi: 10.1016/j.neurobiolaging.2012.02.016. Epub 2012 Mar 27.

PMID:
22459600
[PubMed - indexed for MEDLINE]
16.

Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes.

Plucińska K, Crouch B, Koss D, Robinson L, Siebrecht M, Riedel G, Platt B.

J Neurosci. 2014 Aug 6;34(32):10710-28. doi: 10.1523/JNEUROSCI.0433-14.2014.

PMID:
25100603
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.

Tian J, Shi J, Zhang L, Yin J, Hu Q, Xu Y, Sheng S, Wang P, Ren Y, Wang R, Wang Y.

Curr Alzheimer Res. 2009 Apr;6(2):118-31.

PMID:
19355846
[PubMed - indexed for MEDLINE]
18.

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.

Wu G, Sankaranarayanan S, Hsieh SH, Simon AJ, Savage MJ.

J Neurosci Res. 2011 Jun;89(6):822-32. doi: 10.1002/jnr.22618. Epub 2011 Mar 23.

PMID:
21433051
[PubMed - indexed for MEDLINE]
19.

AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice.

Eketjäll S, Janson J, Jeppsson F, Svanhagen A, Kolmodin K, Gustavsson S, Radesäter AC, Eliason K, Briem S, Appelkvist P, Niva C, Berg AL, Karlström S, Swahn BM, Fälting J.

J Neurosci. 2013 Jun 12;33(24):10075-84. doi: 10.1523/JNEUROSCI.1165-13.2013.

PMID:
23761903
[PubMed - indexed for MEDLINE]
Free Article
20.

p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.

Wang YJ, Wang X, Lu JJ, Li QX, Gao CY, Liu XH, Sun Y, Yang M, Lim Y, Evin G, Zhong JH, Masters C, Zhou XF.

J Neurosci. 2011 Feb 9;31(6):2292-304. doi: 10.1523/JNEUROSCI.2733-10.2011.

PMID:
21307265
[PubMed - indexed for MEDLINE]
Free Article
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