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Items: 1 to 20 of 95

1.

Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.

Biava M, Battilocchio C, Poce G, Alfonso S, Consalvi S, Porretta GC, Schenone S, Calderone V, Martelli A, Testai L, Ghelardini C, Di Cesare Mannelli L, Sautebin L, Rossi A, Giordani A, Patrignani P, Anzini M.

Eur J Med Chem. 2012 Dec;58:287-98. doi: 10.1016/j.ejmech.2012.10.014. Epub 2012 Oct 18.

PMID:
23131542
2.

Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.

Biava M, Battilocchio C, Poce G, Alfonso S, Consalvi S, Di Capua A, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Ghelardini C, Di Cesare Mannelli L, Giordani A, Persiani S, Colovic M, Dovizio M, Patrignani P, Anzini M.

Bioorg Med Chem. 2014 Jan 15;22(2):772-86. doi: 10.1016/j.bmc.2013.12.008. Epub 2013 Dec 18.

PMID:
24373735
3.

Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs.

Brzozowski T, Konturek PC, Konturek SJ, Sliwowski Z, Drozdowicz D, Kwiecień S, Pajdo R, Ptak A, Pawlik M, Hahn E.

Dig Liver Dis. 2000 Oct;32(7):583-94.

PMID:
11142556
4.

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.

Biava M, Porretta GC, Poce G, Supino S, Manetti F, Forli S, Botta M, Sautebin L, Rossi A, Pergola C, Ghelardini C, Norcini M, Makovec F, Giordani A, Anzellotti P, Cirilli R, Ferretti R, Gallinella B, La Torre F, Anzini M, Patrignani P.

Bioorg Med Chem. 2008 Sep 1;16(17):8072-81. doi: 10.1016/j.bmc.2008.07.058. Epub 2008 Jul 24.

PMID:
18752957
5.

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.

Biava M, Porretta GC, Poce G, Battilocchio C, Alfonso S, Rovini M, Valenti S, Giorgi G, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Papa G, Ghelardini C, Di Cesare Mannelli L, Giordani A, Anzellotti P, Bruno A, Patrignani P, Anzini M.

J Med Chem. 2011 Nov 24;54(22):7759-71. doi: 10.1021/jm200715n. Epub 2011 Oct 31.

PMID:
21992176
6.

Synthesis and pharmacological characterization of a novel nitric oxide-releasing diclofenac derivative containing a benzofuroxan moiety.

de Carvalho PS, Maróstica M, Gambero A, Pedrazzoli J Jr.

Eur J Med Chem. 2010 Jun;45(6):2489-93. doi: 10.1016/j.ejmech.2010.02.034. Epub 2010 Feb 20.

PMID:
20227145
7.

Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs.

Bhandari SV, Dangre SC, Bothara KG, Patil AA, Sarkate AP, Lokwani DK, Gore ST, Deshmane BJ, Raparti VT, Khachane CV.

Eur J Med Chem. 2009 Nov;44(11):4622-36. doi: 10.1016/j.ejmech.2009.06.035. Epub 2009 Jul 4.

PMID:
19647903
8.

Acyclic triaryl olefins possessing a sulfohydroxamic acid pharmacophore: synthesis, nitric oxide/nitroxyl release, cyclooxygenase inhibition, and anti-inflammatory studies.

Huang Z, Velázquez C, Abdellatif K, Chowdhury M, Jain S, Reisz J, Dumond J, King SB, Knaus E.

Org Biomol Chem. 2010 Sep 21;8(18):4124-30. doi: 10.1039/c005066k. Epub 2010 Jul 22.

PMID:
20664853
10.

Anti-inflammatory activity of the synthetic C-C biflavonoids.

Park H, Kim YH, Chang HW, Kim HP.

J Pharm Pharmacol. 2006 Dec;58(12):1661-7.

PMID:
17331331
11.

New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.

Janusz JM, Young PA, Ridgeway JM, Scherz MW, Enzweiler K, Wu LI, Gan L, Chen J, Kellstein DE, Green SA, Tulich JL, Rosario-Jansen T, Magrisso IJ, Wehmeyer KR, Kuhlenbeck DL, Eichhold TH, Dobson RL.

J Med Chem. 1998 Aug 27;41(18):3515-29.

PMID:
9719605
12.

Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines.

Almansa C, de Arriba AF, Cavalcanti FL, Gómez LA, Miralles A, Merlos M, García-Rafanell J, Forn J.

J Med Chem. 2001 Feb 1;44(3):350-61.

PMID:
11462976
13.
16.

Cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs and gastric mucosal responses.

Takeuchi K, Suzuki K, Yamamoto H, Araki H, Mizoguchi H, Ukawa H.

J Physiol Pharmacol. 1998 Dec;49(4):501-13.

PMID:
10069692
17.

Nitric oxide releasing derivatives of tolfenamic acid with anti-inflammatory activity and safe gastrointestinal profile.

Ziakas GN, Rekka EA, Gavalas AM, Eleftheriou PT, Tsiakitzis KC, Kourounakis PN.

Bioorg Med Chem. 2005 Dec 1;13(23):6485-92. Epub 2005 Sep 26.

PMID:
16185877
18.

Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.

Song Y, Connor DT, Doubleday R, Sorenson RJ, Sercel AD, Unangst PC, Roth BD, Gilbertsen RB, Chan K, Schrier DJ, Guglietta A, Bornemeier DA, Dyer RD.

J Med Chem. 1999 Apr 8;42(7):1151-60.

PMID:
10197959
19.

Design, synthesis, and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives.

Li MH, Yin LL, Cai MJ, Zhang WY, Huang Y, Wang X, Zhu XZ, Shen JK.

Acta Pharmacol Sin. 2005 Jul;26(7):865-72.

20.

Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae).

Ibrahim B, Sowemimo A, van Rooyen A, Van de Venter M.

J Ethnopharmacol. 2012 May 7;141(1):282-9. doi: 10.1016/j.jep.2012.02.032. Epub 2012 Mar 1.

PMID:
22387161
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