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Results: 1 to 20 of 87

1.

Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease.

Xun Z, Rivera-Sánchez S, Ayala-Peña S, Lim J, Budworth H, Skoda EM, Robbins PD, Niedernhofer LJ, Wipf P, McMurray CT.

Cell Rep. 2012 Nov 29;2(5):1137-42. doi: 10.1016/j.celrep.2012.10.001. Epub 2012 Nov 1.

PMID:
23122961
[PubMed - indexed for MEDLINE]
Free PMC Article
2.
3.

Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease.

Siddiqui A, Rivera-Sánchez S, Castro Mdel R, Acevedo-Torres K, Rane A, Torres-Ramos CA, Nicholls DG, Andersen JK, Ayala-Torres S.

Free Radic Biol Med. 2012 Oct 1;53(7):1478-88. doi: 10.1016/j.freeradbiomed.2012.06.008. Epub 2012 Jun 16.

PMID:
22709585
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease.

Chen CM.

Chang Gung Med J. 2011 Mar-Apr;34(2):135-52. Review.

PMID:
21539755
[PubMed - indexed for MEDLINE]
Free Article
5.

Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease.

Acevedo-Torres K, Berríos L, Rosario N, Dufault V, Skatchkov S, Eaton MJ, Torres-Ramos CA, Ayala-Torres S.

DNA Repair (Amst). 2009 Jan 1;8(1):126-36. doi: 10.1016/j.dnarep.2008.09.004. Epub 2008 Nov 20.

PMID:
18935984
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Probucol modulates oxidative stress and excitotoxicity in Huntington's disease models in vitro.

Colle D, Hartwig JM, Soares FA, Farina M.

Brain Res Bull. 2012 Mar 10;87(4-5):397-405. doi: 10.1016/j.brainresbull.2012.01.003. Epub 2012 Jan 11.

PMID:
22245028
[PubMed - indexed for MEDLINE]
Free Article
7.

Dysregulation of mitochondrial calcium signaling and superoxide flashes cause mitochondrial genomic DNA damage in Huntington disease.

Wang JQ, Chen Q, Wang X, Wang QC, Wang Y, Cheng HP, Guo C, Sun Q, Chen Q, Tang TS.

J Biol Chem. 2013 Feb 1;288(5):3070-84. doi: 10.1074/jbc.M112.407726. Epub 2012 Dec 17.

PMID:
23250749
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease.

Klivenyi P, Ferrante RJ, Gardian G, Browne S, Chabrier PE, Beal MF.

J Neurochem. 2003 Jul;86(1):267-72. Erratum in: J Neurochem. 2003 Oct;87(1):272.

PMID:
12807446
[PubMed - indexed for MEDLINE]
9.

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration.

Nasto LA, Robinson AR, Ngo K, Clauson CL, Dong Q, St Croix C, Sowa G, Pola E, Robbins PD, Kang J, Niedernhofer LJ, Wipf P, Vo NV.

J Orthop Res. 2013 Jul;31(7):1150-7. doi: 10.1002/jor.22320. Epub 2013 Feb 6.

PMID:
23389888
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis.

Ayala-Peña S.

Free Radic Biol Med. 2013 Sep;62:102-10. doi: 10.1016/j.freeradbiomed.2013.04.017. Epub 2013 Apr 18. Review.

PMID:
23602907
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease.

Jia H, Li X, Gao H, Feng Z, Li X, Zhao L, Jia X, Zhang H, Liu J.

J Neurosci Res. 2008 Jul;86(9):2083-90. doi: 10.1002/jnr.21650.

PMID:
18381761
[PubMed - indexed for MEDLINE]
12.

Neuroprotective effects of L-carnitine in a transgenic animal model of Huntington's disease.

Vamos E, Voros K, Vecsei L, Klivenyi P.

Biomed Pharmacother. 2010 Apr;64(4):282-6. doi: 10.1016/j.biopha.2009.06.020. Epub 2009 Oct 27.

PMID:
19932584
[PubMed - indexed for MEDLINE]
13.

Reagents that block neuronal death from Huntington's disease also curb oxidative stress.

Valencia A, Sapp E, Reeves PB, Alexander J, Masso N, Li X, Kegel KB, DiFiglia M.

Neuroreport. 2012 Jan 4;23(1):10-5. doi: 10.1097/WNR.0b013e32834d92e6.

PMID:
22045254
[PubMed - indexed for MEDLINE]
14.

Exploiting proteomics in the discovery of drugs that target mitochondrial oxidative damage.

Gibson BW.

Sci Aging Knowledge Environ. 2004 Mar 17;2004(11):pe12. Review.

PMID:
15028863
[PubMed - indexed for MEDLINE]
15.

Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease.

Johri A, Calingasan NY, Hennessey TM, Sharma A, Yang L, Wille E, Chandra A, Beal MF.

Hum Mol Genet. 2012 Mar 1;21(5):1124-37. doi: 10.1093/hmg/ddr541. Epub 2011 Nov 17.

PMID:
22095692
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Lipoic acid improves survival in transgenic mouse models of Huntington's disease.

Andreassen OA, Ferrante RJ, Dedeoglu A, Beal MF.

Neuroreport. 2001 Oct 29;12(15):3371-3.

PMID:
11711888
[PubMed - indexed for MEDLINE]
17.

Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitochondrial DNA in primary cultured neurons.

Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wang Y, Wang X, Li M, Chen Y, Chen C, He M, Zhang G, Zhong M.

Brain Res. 2010 Jan 22;1311:189-96. doi: 10.1016/j.brainres.2009.10.062. Epub 2009 Oct 30.

PMID:
19879861
[PubMed - indexed for MEDLINE]
18.

Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E.

Butterfield DA, Koppal T, Howard B, Subramaniam R, Hall N, Hensley K, Yatin S, Allen K, Aksenov M, Aksenova M, Carney J.

Ann N Y Acad Sci. 1998 Nov 20;854:448-62. Review.

PMID:
9928452
[PubMed - indexed for MEDLINE]
19.

Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted anti-oxidants.

Fink MP, Macias CA, Xiao J, Tyurina YY, Jiang J, Belikova N, Delude RL, Greenberger JS, Kagan VE, Wipf P.

Biochem Pharmacol. 2007 Sep 15;74(6):801-9. Epub 2007 May 29. Review.

PMID:
17601494
[PubMed - indexed for MEDLINE]
20.

Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease.

Ferrante RJ, Ryu H, Kubilus JK, D'Mello S, Sugars KL, Lee J, Lu P, Smith K, Browne S, Beal MF, Kristal BS, Stavrovskaya IG, Hewett S, Rubinsztein DC, Langley B, Ratan RR.

J Neurosci. 2004 Nov 17;24(46):10335-42.

PMID:
15548647
[PubMed - indexed for MEDLINE]
Free PMC Article

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