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PNUTS functions as a proto-oncogene by sequestering PTEN.

Kavela S, Shinde SR, Ratheesh R, Viswakalyan K, Bashyam MD, Gowrishankar S, Vamsy M, Pattnaik S, Rao S, Sastry RA, Srinivasulu M, Chen J, Maddika S.

Cancer Res. 2013 Jan 1;73(1):205-14. doi: 10.1158/0008-5472.CAN-12-1394. Epub 2012 Nov 1.


Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2.

Lee SJ, Lim CJ, Min JK, Lee JK, Kim YM, Lee JY, Won MH, Kwon YG.

Cell Death Differ. 2007 Jun;14(6):1106-16. Epub 2007 Feb 23.


Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress.

Lehman JA, Waning DL, Batuello CN, Cipriano R, Kadakia MP, Mayo LD.

J Biol Chem. 2011 Oct 21;286(42):36631-40. doi: 10.1074/jbc.M110.217620. Epub 2011 Aug 26.


Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulation.

Lee SJ, Lee JK, Maeng YS, Kim YM, Kwon YG.

Exp Mol Med. 2009 Mar 31;41(3):189-200. doi: 10.3858/emm.2009.41.3.022.


PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway.

Tian T, Nan KJ, Guo H, Wang WJ, Ruan ZP, Wang SH, Liang X, Lu CX.

Oncol Rep. 2010 Jun;23(6):1593-600.


Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells.

Cheng Z, Yang N, Liang W, Yan X, Li L, Pan L.

Leuk Lymphoma. 2012 Jul;53(7):1383-9. doi: 10.3109/10428194.2011.650695. Epub 2012 Jan 31.


The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response.

Landsverk HB, Mora-Bermúdez F, Landsverk OJ, Hasvold G, Naderi S, Bakke O, Ellenberg J, Collas P, Syljuåsen RG, Küntziger T.

EMBO Rep. 2010 Nov;11(11):868-75. doi: 10.1038/embor.2010.134. Epub 2010 Oct 1.


PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation.

Kim YM, Watanabe T, Allen PB, Kim YM, Lee SJ, Greengard P, Nairn AC, Kwon YG.

J Biol Chem. 2003 Apr 18;278(16):13819-28. Epub 2003 Feb 6.


IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells.

Ma J, Sawai H, Matsuo Y, Ochi N, Yasuda A, Takahashi H, Wakasugi T, Funahashi H, Sato M, Takeyama H.

J Surg Res. 2010 May 1;160(1):90-101. doi: 10.1016/j.jss.2008.08.016. Epub 2008 Sep 13.


Identification and characterization of a novel human PP1 phosphatase complex.

Lee JH, You J, Dobrota E, Skalnik DG.

J Biol Chem. 2010 Aug 6;285(32):24466-76. doi: 10.1074/jbc.M110.109801. Epub 2010 Jun 1.


PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner.

Landsverk HB, Kirkhus M, Bollen M, Küntziger T, Collas P.

Biochem J. 2005 Sep 15;390(Pt 3):709-17.


Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity.

Hjelmeland AB, Hjelmeland MD, Shi Q, Hart JL, Bigner DD, Wang XF, Kontos CD, Rich JN.

Cancer Res. 2005 Dec 15;65(24):11276-81.


PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells.

De Leon G, Cavino M, D'Angelo M, Krucher NA.

Int J Oncol. 2010 May;36(5):1269-75.


Regulation of PTEN expression by the SWI/SNF chromatin-remodelling protein BRG1 in human colorectal carcinoma cells.

Watanabe T, Semba S, Yokozaki H.

Br J Cancer. 2011 Jan 4;104(1):146-54. doi: 10.1038/sj.bjc.6606018. Epub 2010 Nov 23.


Phosphatase activity of nuclear PTEN is required for CDX2-mediated intestinal differentiation of gastric carcinoma.

Semba S, Satake S, Matsushita M, Yokozaki H.

Cancer Lett. 2009 Feb 8;274(1):143-50. doi: 10.1016/j.canlet.2008.09.019. Epub 2008 Nov 8.


PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells.

Ma J, Sawai H, Ochi N, Matsuo Y, Xu D, Yasuda A, Takahashi H, Wakasugi T, Takeyama H.

Mol Cell Biochem. 2009 Nov;331(1-2):161-71. doi: 10.1007/s11010-009-0154-x. Epub 2009 May 13.


PTEN inhibits BMI1 function independently of its phosphatase activity.

Fan C, He L, Kapoor A, Rybak AP, De Melo J, Cutz JC, Tang D.

Mol Cancer. 2009 Nov 10;8:98. doi: 10.1186/1476-4598-8-98.


Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases.

Mistafa O, Ghalali A, Kadekar S, Högberg J, Stenius U.

J Biol Chem. 2010 Sep 3;285(36):27900-10. doi: 10.1074/jbc.M110.117093. Epub 2010 Jul 6.

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