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Items: 1 to 20 of 105

1.

Ovarian cancer cells, not normal cells, are damaged by Mirk/Dyrk1B kinase inhibition.

Hu J, Deng H, Friedman EA.

Int J Cancer. 2013 May 15;132(10):2258-69. doi: 10.1002/ijc.27917. Epub 2012 Nov 21. Erratum in: Int J Cancer. 2015 Sep 15;137(6):E13.

2.

Mirk/dyrk1B Kinase in Ovarian Cancer.

Friedman E.

Int J Mol Sci. 2013 Mar 8;14(3):5560-75. doi: 10.3390/ijms14035560.

3.

Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells.

Ewton DZ, Hu J, Vilenchik M, Deng X, Luk KC, Polonskaia A, Hoffman AF, Zipf K, Boylan JF, Friedman EA.

Mol Cancer Ther. 2011 Nov;10(11):2104-14. doi: 10.1158/1535-7163.MCT-11-0498. Epub 2011 Aug 30.

4.

Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by both Mirk/dyrk1b and p130/RB2.

Hu J, Nakhla H, Friedman E.

Int J Cancer. 2011 Jul 15;129(2):307-18. doi: 10.1002/ijc.25692. Epub 2010 Nov 18.

5.

Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species.

Deng X, Ewton DZ, Friedman E.

Cancer Res. 2009 Apr 15;69(8):3317-24. doi: 10.1158/0008-5472.CAN-08-2903. Epub 2009 Apr 7.

6.

Mirk regulates the exit of colon cancer cells from quiescence.

Jin K, Ewton DZ, Park S, Hu J, Friedman E.

J Biol Chem. 2009 Aug 21;284(34):22916-25. doi: 10.1074/jbc.M109.035519. Epub 2009 Jun 19.

7.

The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer.

Gao J, Yang X, Yin P, Hu W, Liao H, Miao Z, Pan C, Li N.

Int J Oncol. 2012 Apr;40(4):1203-9. doi: 10.3892/ijo.2011.1293. Epub 2011 Dec 12.

8.

Mirk kinase inhibition targets ovarian cancer ascites.

Deng X, Hu J, Cunningham MJ, Friedman E.

Genes Cancer. 2014 May;5(5-6):201-11.

9.

Mirk/dyrk1B kinase is upregulated following inhibition of mTOR.

Deng X, Hu J, Ewton DZ, Friedman E.

Carcinogenesis. 2014 Sep;35(9):1968-76. doi: 10.1093/carcin/bgu058. Epub 2014 Mar 3.

10.

Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells.

Gao J, Zhao Y, Lv Y, Chen Y, Wei B, Tian J, Yang Z, Kong F, Pang J, Liu J, Shi H.

Cancer Cell Int. 2013 Jan 11;13(1):2. doi: 10.1186/1475-2867-13-2.

11.
12.

The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase.

Deng X, Mercer SE, Shah S, Ewton DZ, Friedman E.

J Biol Chem. 2004 May 21;279(21):22498-504. Epub 2004 Mar 9.

13.

Mirk/Dyrk1B in cancer.

Friedman E.

J Cell Biochem. 2007 Oct 1;102(2):274-9. Review.

PMID:
17583556
14.

Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells.

Gao J, Zheng Z, Rawal B, Schell MJ, Bepler G, Haura EB.

Cancer Biol Ther. 2009 Sep;8(17):1671-9. Epub 2009 Sep 20.

15.

Mirk kinase inhibition blocks the in vivo growth of pancreatic cancer cells.

Deng X, Friedman E.

Genes Cancer. 2014 Sep;5(9-10):337-47.

16.

Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice.

Masuda T, Itoh K, Higashitsuji H, Higashitsuji H, Nakazawa N, Sakurai T, Liu Y, Tokuchi H, Fujita T, Zhao Y, Nishiyama H, Tanaka T, Fukumoto M, Ikawa M, Okabe M, Fujita J.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10885-90. doi: 10.1073/pnas.1121524109. Epub 2012 Jun 18.

17.

Rapid turnover of cell-cycle regulators found in Mirk/dyrk1B transfectants.

Ewton DZ, Lee K, Deng X, Lim S, Friedman E.

Int J Cancer. 2003 Jan 1;103(1):21-8.

18.

The normal function of the cancer kinase Mirk/dyrk1B is to reduce reactive oxygen species.

Deng X, Mercer SE, Sun CY, Friedman E.

Genes Cancer. 2014 Apr;5(1-2):22-30.

19.

The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer.

Jin K, Park S, Ewton DZ, Friedman E.

Cancer Res. 2007 Aug 1;67(15):7247-55.

20.

Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288.

Zou Y, Ewton DZ, Deng X, Mercer SE, Friedman E.

J Biol Chem. 2004 Jun 25;279(26):27790-8. Epub 2004 Apr 9.

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