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Results: 1 to 20 of 104

1.

Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets.

Wulff H, Köhler R.

J Cardiovasc Pharmacol. 2013 Feb;61(2):102-12. doi: 10.1097/FJC.0b013e318279ba20. Review.

PMID:
23107876
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications.

Wulff H, Kolski-Andreaco A, Sankaranarayanan A, Sabatier JM, Shakkottai V.

Curr Med Chem. 2007;14(13):1437-57. Review.

PMID:
17584055
[PubMed - indexed for MEDLINE]
3.

Novel phenolic inhibitors of small/intermediate-conductance Ca²⁺-activated K⁺ channels, KCa3.1 and KCa2.3.

Oliván-Viguera A, Valero MS, Murillo MD, Wulff H, García-Otín AL, Arbonés-Mainar JM, Köhler R.

PLoS One. 2013;8(3):e58614. doi: 10.1371/journal.pone.0058614. Epub 2013 Mar 14.

PMID:
23516517
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.

Sankaranarayanan A, Raman G, Busch C, Schultz T, Zimin PI, Hoyer J, Köhler R, Wulff H.

Mol Pharmacol. 2009 Feb;75(2):281-95. doi: 10.1124/mol.108.051425. Epub 2008 Oct 27.

PMID:
18955585
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery.

Grgic I, Kaistha BP, Hoyer J, Köhler R.

Br J Pharmacol. 2009 Jun;157(4):509-26. doi: 10.1111/j.1476-5381.2009.00132.x. Epub 2009 Mar 19. Review.

PMID:
19302590
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs.

Damkjaer M, Nielsen G, Bodendiek S, Staehr M, Gramsbergen JB, de Wit C, Jensen BL, Simonsen U, Bie P, Wulff H, Köhler R.

Br J Pharmacol. 2012 Jan;165(1):223-34. doi: 10.1111/j.1476-5381.2011.01546.x.

PMID:
21699504
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+ -activated K+ -channels.

Hasenau AL, Nielsen G, Morisseau C, Hammock BD, Wulff H, Köhler R.

Acta Physiol (Oxf). 2011 Sep;203(1):117-26. doi: 10.1111/j.1748-1716.2010.02240.x. Epub 2011 Mar 1.

PMID:
21362152
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo.

Wölfle SE, Schmidt VJ, Hoyer J, Köhler R, de Wit C.

Cardiovasc Res. 2009 Jun 1;82(3):476-83. doi: 10.1093/cvr/cvp060. Epub 2009 Feb 13.

PMID:
19218287
[PubMed - indexed for MEDLINE]
Free Article
9.

Laminar shear stress upregulates endothelial Ca²⁺-activated K⁺ channels KCa2.3 and KCa3.1 via a Ca²⁺/calmodulin-dependent protein kinase kinase/Akt/p300 cascade.

Takai J, Santu A, Zheng H, Koh SD, Ohta M, Filimban LM, Lemaître V, Teraoka R, Jo H, Miura H.

Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H484-93. doi: 10.1152/ajpheart.00642.2012. Epub 2013 Jun 21.

PMID:
23792675
[PubMed - indexed for MEDLINE]
10.

Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease.

Köhler R, Kaistha BP, Wulff H.

Expert Opin Ther Targets. 2010 Feb;14(2):143-55. doi: 10.1517/14728220903540257. Review.

PMID:
20055714
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice.

Köhler R, Ruth P.

Pflugers Arch. 2010 May;459(6):969-76. doi: 10.1007/s00424-010-0819-z. Epub 2010 Mar 28. Review.

PMID:
20349244
[PubMed - indexed for MEDLINE]
12.

Role of S3 and S4 transmembrane domain charged amino acids in channel biogenesis and gating of KCa2.3 and KCa3.1.

Gao Y, Chotoo CK, Balut CM, Sun F, Bailey MA, Devor DC.

J Biol Chem. 2008 Apr 4;283(14):9049-59. doi: 10.1074/jbc.M708022200. Epub 2008 Jan 28.

PMID:
18227067
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases.

Lam J, Coleman N, Garing AL, Wulff H.

Expert Opin Ther Targets. 2013 Oct;17(10):1203-20. doi: 10.1517/14728222.2013.823161. Epub 2013 Jul 25. Review.

PMID:
23883298
[PubMed - indexed for MEDLINE]
14.

Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?

Balut CM, Hamilton KL, Devor DC.

ChemMedChem. 2012 Oct;7(10):1741-55. doi: 10.1002/cmdc.201200226. Epub 2012 Aug 7. Review.

PMID:
22887933
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels.

Sones WR, Leblanc N, Greenwood IA.

Br J Pharmacol. 2009 Sep;158(2):521-31. doi: 10.1111/j.1476-5381.2009.00332.x. Epub 2009 Jul 23.

PMID:
19645713
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease.

Köhler R.

Pflugers Arch. 2010 Jul;460(2):343-51. doi: 10.1007/s00424-009-0768-6. Epub 2009 Dec 31. Review.

PMID:
20043229
[PubMed - indexed for MEDLINE]
17.

NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats.

Brøndum E, Kold-Petersen H, Simonsen U, Aalkjaer C.

Br J Pharmacol. 2010 Jan;159(1):154-65. doi: 10.1111/j.1476-5381.2009.00525.x. Epub 2009 Dec 10.

PMID:
20015296
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity.

Senadheera S, Kim Y, Grayson TH, Toemoe S, Kochukov MY, Abramowitz J, Housley GD, Bertrand RL, Chadha PS, Bertrand PP, Murphy TV, Tare M, Birnbaumer L, Marrelli SP, Sandow SL.

Cardiovasc Res. 2012 Sep 1;95(4):439-47. doi: 10.1093/cvr/cvs208. Epub 2012 Jun 21.

PMID:
22721989
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

KCa2.3 channel-dependent hyperpolarization increases melanoma cell motility.

Chantome A, Girault A, Potier M, Collin C, Vaudin P, Pagès JC, Vandier C, Joulin V.

Exp Cell Res. 2009 Dec 10;315(20):3620-30. doi: 10.1016/j.yexcr.2009.07.021. Epub 2009 Jul 30.

PMID:
19646982
[PubMed - indexed for MEDLINE]
20.

Small- and intermediate-conductance Ca2+-activated K+ channels directly control agonist-evoked nitric oxide synthesis in human vascular endothelial cells.

Sheng JZ, Braun AP.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C458-67. Epub 2007 Apr 25.

PMID:
17459950
[PubMed - indexed for MEDLINE]
Free Article

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