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Results: 1 to 20 of 142

Similar articles for PubMed (Select 23098609)

1.

Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach.

Zhan P, Chen W, Li Z, Li X, Chen X, Tian Y, Pannecouque C, Clercq ED, Liu X.

Bioorg Med Chem. 2012 Dec 1;20(23):6795-802. doi: 10.1016/j.bmc.2012.09.058. Epub 2012 Oct 6.

PMID:
23098609
2.

Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs.

Zhan P, Li X, Li Z, Chen X, Tian Y, Chen W, Liu X, Pannecouque C, De Clercq E.

Bioorg Med Chem Lett. 2012 Dec 1;22(23):7155-62. doi: 10.1016/j.bmcl.2012.09.062. Epub 2012 Oct 2.

PMID:
23084898
3.

Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors.

Zhan P, Chen X, Li X, Li D, Tian Y, Chen W, Pannecouque C, De Clercq E, Liu X.

Eur J Med Chem. 2011 Oct;46(10):5039-45. doi: 10.1016/j.ejmech.2011.08.011. Epub 2011 Aug 12.

PMID:
21872971
4.

Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Zhan P, Liu X, Fang Z, Li Z, Pannecouque C, De Clercq E.

Eur J Med Chem. 2009 Nov;44(11):4648-53. doi: 10.1016/j.ejmech.2009.06.037. Epub 2009 Jul 4.

PMID:
19628308
5.

Synthesis and biological activity of naphthyl-substituted (B-ring) benzophenone derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Ma XD, Zhang X, Dai HF, Yang SQ, Yang LM, Gu SX, Zheng YT, He QQ, Chen FE.

Bioorg Med Chem. 2011 Aug 1;19(15):4601-7. doi: 10.1016/j.bmc.2011.06.007. Epub 2011 Jun 15.

PMID:
21719299
6.

Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs.

Gu SX, Yang SQ, He QQ, Ma XD, Chen FE, Dai HF, Clercq ED, Balzarini J, Pannecouque C.

Bioorg Med Chem. 2011 Dec 1;19(23):7093-9. doi: 10.1016/j.bmc.2011.10.002. Epub 2011 Oct 7.

PMID:
22037050
7.

Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses.

Tang G, Kertesz DJ, Yang M, Lin X, Wang Z, Li W, Qiu Z, Chen J, Mei J, Chen L, Mirzadegan T, Harris SF, Villaseñor AG, Fretland J, Fitch WL, Hang JQ, Heilek G, Klumpp K.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6020-3. doi: 10.1016/j.bmcl.2010.08.068. Epub 2010 Aug 19.

PMID:
20829038
8.

Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies.

Zhan P, Liu X, Li Z, Fang Z, Li Z, Wang D, Pannecouque C, Clercq ED.

Bioorg Med Chem. 2009 Aug 15;17(16):5920-7. doi: 10.1016/j.bmc.2009.07.004. Epub 2009 Jul 7.

PMID:
19620009
9.

Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents.

Zhan P, Wang L, Liu H, Chen X, Li X, Jiang X, Zhang Q, Liu X, Pannecouque C, Naesens L, De Clercq E, Liu A, Du G.

Arch Pharm Res. 2012 Jun;35(6):975-86. doi: 10.1007/s12272-012-0604-y. Epub 2012 Jun 30.

PMID:
22870806
10.

Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Tian X, Qin B, Lu H, Lai W, Jiang S, Lee KH, Chen CH, Xie L.

Bioorg Med Chem Lett. 2009 Sep 15;19(18):5482-5. doi: 10.1016/j.bmcl.2009.07.080. Epub 2009 Jul 19.

11.

Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs.

Rai D, Chen W, Tian Y, Chen X, Zhan P, De Clercq E, Pannecouque C, Balzarini J, Liu X.

Bioorg Med Chem. 2013 Dec 1;21(23):7398-405. doi: 10.1016/j.bmc.2013.09.051. Epub 2013 Oct 1.

PMID:
24134904
12.

Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors.

Chen X, Zhan P, Liu X, Cheng Z, Meng C, Shao S, Pannecouque C, De Clercq E, Liu X.

Bioorg Med Chem. 2012 Jun 15;20(12):3856-64. doi: 10.1016/j.bmc.2012.04.030. Epub 2012 Apr 21.

PMID:
22591854
13.

Structure-based design, parallel synthesis, structure-activity relationship, and molecular modeling studies of thiocarbamates, new potent non-nucleoside HIV-1 reverse transcriptase inhibitor isosteres of phenethylthiazolylthiourea derivatives.

Ranise A, Spallarossa A, Cesarini S, Bondavalli F, Schenone S, Bruno O, Menozzi G, Fossa P, Mosti L, La Colla M, Sanna G, Murreddu M, Collu G, Busonera B, Marongiu ME, Pani A, La Colla P, Loddo R.

J Med Chem. 2005 Jun 2;48(11):3858-73.

PMID:
15916438
14.

Synthesis and biological evaluation of (±)-benzhydrol derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Ma XD, Zhang X, Yang SQ, Dai HF, Yang LM, Gu SX, Zheng YT, He QQ, Chen FE.

Bioorg Med Chem. 2011 Aug 15;19(16):4704-9. doi: 10.1016/j.bmc.2011.07.003. Epub 2011 Jul 13.

PMID:
21788138
15.

Virtual screening studies on HIV-1 reverse transcriptase inhibitors to design potent leads.

Vadivelan S, Deeksha TN, Arun S, Machiraju PK, Gundla R, Sinha BN, Jagarlapudi SA.

Eur J Med Chem. 2011 Mar;46(3):851-9. doi: 10.1016/j.ejmech.2010.12.022. Epub 2011 Jan 9.

PMID:
21272964
16.

Lead optimization at C-2 and N-3 positions of thiazolidin-4-ones as HIV-1 non-nucleoside reverse transcriptase inhibitors.

Murugesan V, Tiwari VS, Saxena R, Tripathi R, Paranjape R, Kulkarni S, Makwana N, Suryawanshi R, Katti SB.

Bioorg Med Chem. 2011 Nov 15;19(22):6919-26. doi: 10.1016/j.bmc.2011.09.018. Epub 2011 Sep 13.

PMID:
21982685
17.

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.

Ludovici DW, Kavash RW, Kukla MJ, Ho CY, Ye H, De Corte BL, Andries K, de Béthune MP, Azijn H, Pauwels R, Moereels HE, Heeres J, Koymans LM, de Jonge MR, Van Aken KJ, Daeyaert FF, Lewi PJ, Das K, Arnold E, Janssen PA.

Bioorg Med Chem Lett. 2001 Sep 3;11(17):2229-34.

PMID:
11527704
18.

1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

Zhan P, Liu X, Cao Y, Wang Y, Pannecouque C, De Clercq E.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5368-71. doi: 10.1016/j.bmcl.2008.09.055. Epub 2008 Sep 18.

PMID:
18824350
19.

Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays.

Chen W, Zhan P, Rai D, De Clercq E, Pannecouque C, Balzarini J, Zhou Z, Liu H, Liu X.

Bioorg Med Chem. 2014 Mar 15;22(6):1863-72. doi: 10.1016/j.bmc.2014.01.054. Epub 2014 Feb 6.

PMID:
24581546
20.

Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy.

Zeng ZS, He QQ, Liang YH, Feng XQ, Chen FE, De Clercq E, Balzarini J, Pannecouque C.

Bioorg Med Chem. 2010 Jul 15;18(14):5039-47. doi: 10.1016/j.bmc.2010.05.081. Epub 2010 Jun 4.

PMID:
20598556
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