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Results: 1 to 20 of 107

1.

Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1).

Xing L, Salas M, Zhang H, Gittler J, Ludwig T, Lin CS, Murty VV, Silverman W, Arancio O, Tycko B.

Mamm Genome. 2013 Feb;24(1-2):30-43. doi: 10.1007/s00335-012-9436-9. Epub 2012 Oct 25.

PMID:
23096997
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.

Martin KR, Corlett A, Dubach D, Mustafa T, Coleman HA, Parkington HC, Merson TD, Bourne JA, Porta S, Arbonés ML, Finkelstein DI, Pritchard MA.

Hum Mol Genet. 2012 Jul 1;21(13):3025-41. doi: 10.1093/hmg/dds134. Epub 2012 Apr 17.

PMID:
22511596
[PubMed - indexed for MEDLINE]
Free Article
3.

Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation.

Jung MS, Park JH, Ryu YS, Choi SH, Yoon SH, Kwen MY, Oh JY, Song WJ, Chung SH.

J Biol Chem. 2011 Nov 18;286(46):40401-12. doi: 10.1074/jbc.M111.253971. Epub 2011 Sep 30.

PMID:
21965663
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease.

Keating DJ, Dubach D, Zanin MP, Yu Y, Martin K, Zhao YF, Chen C, Porta S, Arbonés ML, Mittaz L, Pritchard MA.

Hum Mol Genet. 2008 Apr 1;17(7):1020-30. doi: 10.1093/hmg/ddm374. Epub 2008 Jan 7.

PMID:
18180251
[PubMed - indexed for MEDLINE]
Free Article
5.

The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling.

Hoeffer CA, Dey A, Sachan N, Wong H, Patterson RJ, Shelton JM, Richardson JA, Klann E, Rothermel BA.

J Neurosci. 2007 Nov 28;27(48):13161-72.

PMID:
18045910
[PubMed - indexed for MEDLINE]
Free Article
6.

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.

Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S.

Nature. 2009 Jun 25;459(7250):1126-30. doi: 10.1038/nature08062. Epub 2009 May 20.

PMID:
19458618
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.

Dierssen M, Arqué G, McDonald J, Andreu N, Martínez-Cué C, Flórez J, Fillat C.

PLoS One. 2011 Feb 25;6(2):e17010. doi: 10.1371/journal.pone.0017010.

PMID:
21364922
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.

Sun X, Wu Y, Chen B, Zhang Z, Zhou W, Tong Y, Yuan J, Xia K, Gronemeyer H, Flavell RA, Song W.

J Biol Chem. 2011 Mar 18;286(11):9049-62. doi: 10.1074/jbc.M110.177519. Epub 2011 Jan 7.

PMID:
21216952
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

A hidden incoherent switch regulates RCAN1 in the calcineurin-NFAT signaling network.

Shin SY, Yang HW, Kim JR, Heo WD, Cho KH.

J Cell Sci. 2011 Jan 1;124(Pt 1):82-90. doi: 10.1242/jcs.076034.

PMID:
21172821
[PubMed - indexed for MEDLINE]
Free Article
10.

Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease.

Lloret A, Badia MC, Giraldo E, Ermak G, Alonso MD, Pallardó FV, Davies KJ, Viña J.

J Alzheimers Dis. 2011;27(4):701-9. doi: 10.3233/JAD-2011-110890.

PMID:
21876249
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.

Porta S, Serra SA, Huch M, Valverde MA, Llorens F, Estivill X, Arbonés ML, Martí E.

Hum Mol Genet. 2007 May 1;16(9):1039-50. Epub 2007 Mar 6.

PMID:
17341486
[PubMed - indexed for MEDLINE]
Free Article
12.

Protein kinase A phosphorylates Down syndrome critical region 1 (RCAN1).

Kim SS, Oh Y, Chung KC, Seo SR.

Biochem Biophys Res Commun. 2012 Feb 24;418(4):657-61. doi: 10.1016/j.bbrc.2012.01.071. Epub 2012 Jan 24.

PMID:
22293192
[PubMed - indexed for MEDLINE]
13.

RCAN1 (DSCR1 or Adapt78) stimulates expression of GSK-3beta.

Ermak G, Harris CD, Battocchio D, Davies KJ.

FEBS J. 2006 May;273(10):2100-9.

PMID:
16649988
[PubMed - indexed for MEDLINE]
14.

Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling.

Shaw JL, Chang KT.

PLoS Genet. 2013;9(9):e1003792. doi: 10.1371/journal.pgen.1003792. Epub 2013 Sep 26.

PMID:
24086147
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis.

Shin J, Lee JC, Baek KH.

Cancer Lett. 2014 Jan 1;342(1):70-81. doi: 10.1016/j.canlet.2013.08.047. Epub 2013 Sep 16.

PMID:
24051307
[PubMed - indexed for MEDLINE]
16.

Regulator of calcineurin 1 controls growth plasticity of adult pancreas.

Gurda GT, Crozier SJ, Ji B, Ernst SA, Logsdon CD, Rothermel BA, Williams JA.

Gastroenterology. 2010 Aug;139(2):609-19, 619.e1-6. doi: 10.1053/j.gastro.2010.04.050. Epub 2010 Jun 18.

PMID:
20438729
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Upregulation of RCAN1 causes Down syndrome-like immune dysfunction.

Martin KR, Layton D, Seach N, Corlett A, Barallobre MJ, Arbonés ML, Boyd RL, Scott B, Pritchard MA.

J Med Genet. 2013 Jul;50(7):444-54. doi: 10.1136/jmedgenet-2013-101522. Epub 2013 May 3.

PMID:
23644448
[PubMed - indexed for MEDLINE]
18.

Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease.

Ermak G, Davies KJ.

Free Radic Biol Med. 2013 Sep;62:47-51. doi: 10.1016/j.freeradbiomed.2013.01.016. Epub 2013 Jan 29. Review.

PMID:
23369757
[PubMed - indexed for MEDLINE]
19.

Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment.

Hoeffer CA, Wong H, Cain P, Levenga J, Cowansage KK, Choi Y, Davy C, Majmundar N, McMillan DR, Rothermel BA, Klann E.

J Neurosci. 2013 Oct 23;33(43):16930-44. doi: 10.1523/JNEUROSCI.3513-12.2013.

PMID:
24155299
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

CREB activates proteasomal degradation of DSCR1/RCAN1.

Seo SR, Chung KC.

FEBS Lett. 2008 Jun 11;582(13):1889-93. doi: 10.1016/j.febslet.2008.04.059. Epub 2008 May 15.

PMID:
18485898
[PubMed - indexed for MEDLINE]
Free Article

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