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Results: 1 to 20 of 175

1.

Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at the GLP-1 receptor.

Li N, Lu J, Willars GB.

PLoS One. 2012;7(10):e47936. doi: 10.1371/journal.pone.0047936. Epub 2012 Oct 19.

PMID:
23094100
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Comparative effects of the endogenous agonist glucagon-like peptide-1 (GLP-1)-(7-36) amide and the small-molecule ago-allosteric agent "compound 2" at the GLP-1 receptor.

Coopman K, Huang Y, Johnston N, Bradley SJ, Wilkinson GF, Willars GB.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):795-808. doi: 10.1124/jpet.110.166009. Epub 2010 May 27.

PMID:
20507928
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently.

Cheong YH, Kim MK, Son MH, Kaang BK.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):558-63. doi: 10.1016/j.bbrc.2011.12.004. Epub 2011 Dec 8.

PMID:
22177947
[PubMed - indexed for MEDLINE]
4.

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

Göke R, Fehmann HC, Linn T, Schmidt H, Krause M, Eng J, Göke B.

J Biol Chem. 1993 Sep 15;268(26):19650-5.

PMID:
8396143
[PubMed - indexed for MEDLINE]
Free Article
5.

Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor.

Ban K, Kim KH, Cho CK, Sauvé M, Diamandis EP, Backx PH, Drucker DJ, Husain M.

Endocrinology. 2010 Apr;151(4):1520-31. doi: 10.1210/en.2009-1197. Epub 2010 Feb 19.

PMID:
20172966
[PubMed - indexed for MEDLINE]
6.

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.

Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.

J Biol Chem. 2012 Feb 3;287(6):3642-58. doi: 10.1074/jbc.M111.309328. Epub 2011 Dec 6.

PMID:
22147710
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Glucagon-like peptide-1 improves insulin and proinsulin binding on RINm5F cells and human monocytes.

Ebinger M, Jehle DR, Fussgaenger RD, Fehmann HC, Jehle PM.

Am J Physiol Endocrinol Metab. 2000 Jul;279(1):E88-94.

PMID:
10893327
[PubMed - indexed for MEDLINE]
Free Article
8.

Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

Koole C, Wootten D, Simms J, Valant C, Sridhar R, Woodman OL, Miller LJ, Summers RJ, Christopoulos A, Sexton PM.

Mol Pharmacol. 2010 Sep;78(3):456-65. doi: 10.1124/mol.110.065664. Epub 2010 Jun 14.

PMID:
20547734
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.

Koole C, Wootten D, Simms J, Savage EE, Miller LJ, Christopoulos A, Sexton PM.

J Biol Chem. 2012 Feb 3;287(6):3659-73. doi: 10.1074/jbc.M111.309369. Epub 2011 Dec 6.

PMID:
22147709
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39).

Green BD, Mooney MH, Gault VA, Irwin N, Bailey CJ, Harriott P, Greer B, Flatt PR, O'Harte FP.

Metabolism. 2004 Feb;53(2):252-9.

PMID:
14767880
[PubMed - indexed for MEDLINE]
11.

Value of the radiolabelled GLP-1 receptor antagonist exendin(9-39) for targeting of GLP-1 receptor-expressing pancreatic tissues in mice and humans.

Waser B, Reubi JC.

Eur J Nucl Med Mol Imaging. 2011 Jun;38(6):1054-8. doi: 10.1007/s00259-010-1701-0. Epub 2011 Jan 6.

PMID:
21210113
[PubMed - indexed for MEDLINE]
12.

Divergent effects of GLP-1 analogs exendin-4 and exendin-9 on the expression of myosin heavy chain isoforms in C2C12 myotubes.

Wang L, Guo F, Wei S, Zhao R.

Peptides. 2011 Jun;32(6):1313-9. doi: 10.1016/j.peptides.2011.03.018. Epub 2011 Mar 29.

PMID:
21453734
[PubMed - indexed for MEDLINE]
13.

Regulation of glucagon-like peptide-1 receptor and calcium-sensing receptor signaling by L-histidine.

Leech CA, Habener JF.

Endocrinology. 2003 Nov;144(11):4851-8. Epub 2003 Jul 24.

PMID:
12959987
[PubMed - indexed for MEDLINE]
14.

Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis.

Marzioni M, Alpini G, Saccomanno S, Candelaresi C, Venter J, Rychlicki C, Fava G, Francis H, Trozzi L, Glaser S, Benedetti A.

Gastroenterology. 2007 Jul;133(1):244-55.

PMID:
17631146
[PubMed - indexed for MEDLINE]
15.

GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide.

Elahi D, Egan JM, Shannon RP, Meneilly GS, Khatri A, Habener JF, Andersen DK.

Obesity (Silver Spring). 2008 Jul;16(7):1501-9. doi: 10.1038/oby.2008.229. Epub 2008 Apr 17.

PMID:
18421270
[PubMed - indexed for MEDLINE]
16.

The peptide-hormone glucagon-like peptide-1 activates cAMP and inhibits growth of breast cancer cells.

Ligumsky H, Wolf I, Israeli S, Haimsohn M, Ferber S, Karasik A, Kaufman B, Rubinek T.

Breast Cancer Res Treat. 2012 Apr;132(2):449-61. doi: 10.1007/s10549-011-1585-0. Epub 2011 Jun 3.

PMID:
21638053
[PubMed - indexed for MEDLINE]
17.

Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.

Koole C, Wootten D, Simms J, Valant C, Miller LJ, Christopoulos A, Sexton PM.

Mol Pharmacol. 2011 Sep;80(3):486-97. doi: 10.1124/mol.111.072884. Epub 2011 May 26. Erratum in: Mol Pharmacol. 2012 Jul;82(1):142.

PMID:
21616920
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide.

Kolligs F, Fehmann HC, Göke R, Göke B.

Diabetes. 1995 Jan;44(1):16-9.

PMID:
7813808
[PubMed - indexed for MEDLINE]
19.

Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.

Baggio LL, Huang Q, Brown TJ, Drucker DJ.

Gastroenterology. 2004 Aug;127(2):546-58.

PMID:
15300587
[PubMed - indexed for MEDLINE]
20.

Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo.

Kim JG, Baggio LL, Bridon DP, Castaigne JP, Robitaille MF, Jetté L, Benquet C, Drucker DJ.

Diabetes. 2003 Mar;52(3):751-9.

PMID:
12606517
[PubMed - indexed for MEDLINE]
Free Article

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