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Results: 1 to 20 of 98

1.

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.

Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ.

Nat Chem Biol. 2012 Dec;8(12):982-9. doi: 10.1038/nchembio.1094. Epub 2012 Oct 21.

PMID:
23086298
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR.

Cell. 2009 Aug 7;138(3):562-75. doi: 10.1016/j.cell.2009.07.017.

PMID:
19665977
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.

Mimura N, Fulciniti M, Gorgun G, Tai YT, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H, Kiziltepe T, Ikeda H, Kawano Y, French M, Blumenthal M, Tam V, Kertesz NL, Malyankar UM, Hokenson M, Pham T, Zeng Q, Patterson JB, Richardson PG, Munshi NC, Anderson KC.

Blood. 2012 Jun 14;119(24):5772-81. doi: 10.1182/blood-2011-07-366633. Epub 2012 Apr 26.

PMID:
22538852
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.

Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ.

Genes Dev. 2002 Feb 15;16(4):452-66.

PMID:
11850408
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress.

Back SH, Lee K, Vink E, Kaufman RJ.

J Biol Chem. 2006 Jul 7;281(27):18691-706. Epub 2006 Apr 27.

PMID:
16644724
[PubMed - indexed for MEDLINE]
Free Article
6.

Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.

Newbatt Y, Hardcastle A, McAndrew PC, Strover JA, Mirza A, Morgan GJ, Burke R, Davies FE, Collins I, van Montfort RL.

J Biomol Screen. 2013 Mar;18(3):298-308. doi: 10.1177/1087057112465647. Epub 2012 Nov 8.

PMID:
23139381
[PubMed - indexed for MEDLINE]
7.

A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.

Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR.

Biochem Biophys Res Commun. 2008 Jan 25;365(4):777-83. Epub 2007 Nov 21.

PMID:
18035051
[PubMed - indexed for MEDLINE]
8.

Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells.

Wang FM, Galson DL, Roodman GD, Ouyang H.

Exp Hematol. 2011 Oct;39(10):999-1006. doi: 10.1016/j.exphem.2011.06.007. Epub 2011 Jul 1.

PMID:
21723843
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ.

J Clin Invest. 2005 Feb;115(2):268-81.

PMID:
15690081
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Experimental approaches for elucidation of stress-sensing mechanisms of the IRE1 family proteins.

Oikawa D, Kimata Y.

Methods Enzymol. 2011;490:195-216. doi: 10.1016/B978-0-12-385114-7.00012-X.

PMID:
21266252
[PubMed - indexed for MEDLINE]
11.

HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction.

Gupta S, Deepti A, Deegan S, Lisbona F, Hetz C, Samali A.

PLoS Biol. 2010 Jul 6;8(7):e1000410. doi: 10.1371/journal.pbio.1000410.

PMID:
20625543
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.

Ali MM, Bagratuni T, Davenport EL, Nowak PR, Silva-Santisteban MC, Hardcastle A, McAndrews C, Rowlands MG, Morgan GJ, Aherne W, Collins I, Davies FE, Pearl LH.

EMBO J. 2011 Mar 2;30(5):894-905. doi: 10.1038/emboj.2011.18. Epub 2011 Feb 11.

PMID:
21317875
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress.

Bouchecareilh M, Higa A, Fribourg S, Moenner M, Chevet E.

FASEB J. 2011 Sep;25(9):3115-29. doi: 10.1096/fj.11-182931. Epub 2011 Jun 16.

PMID:
21680894
[PubMed - indexed for MEDLINE]
Free Article
14.

Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.

Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, Sicheri F, Patterson JB.

J Biol Chem. 2011 Apr 8;286(14):12743-55. doi: 10.1074/jbc.M110.199737. Epub 2011 Feb 8.

PMID:
21303903
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells.

Hosoi T, Korematsu K, Horie N, Suezawa T, Okuma Y, Nomura Y, Ozawa K.

PLoS One. 2012;7(6):e40144. doi: 10.1371/journal.pone.0040144. Epub 2012 Jun 29.

PMID:
22768244
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis.

Tohmonda T, Yoda M, Mizuochi H, Morioka H, Matsumoto M, Urano F, Toyama Y, Horiuchi K.

J Biol Chem. 2013 Jan 18;288(3):1691-5. doi: 10.1074/jbc.C112.424606. Epub 2012 Dec 12.

PMID:
23235147
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR.

Cell Metab. 2012 Aug 8;16(2):250-64. doi: 10.1016/j.cmet.2012.07.007.

PMID:
22883233
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA.

Science. 2012 Nov 9;338(6108):818-22. doi: 10.1126/science.1226191. Epub 2012 Oct 4.

PMID:
23042294
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy.

Hernández-Gea V, Hilscher M, Rozenfeld R, Lim MP, Nieto N, Werner S, Devi LA, Friedman SL.

J Hepatol. 2013 Jul;59(1):98-104. doi: 10.1016/j.jhep.2013.02.016. Epub 2013 Feb 26.

PMID:
23485523
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins.

Oikawa D, Iwawaki T.

Biochem Biophys Res Commun. 2013 Apr 19;433(4):426-31. doi: 10.1016/j.bbrc.2013.02.119. Epub 2013 Mar 26.

PMID:
23541586
[PubMed - indexed for MEDLINE]

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