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Results: 1 to 20 of 105

1.

The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity.

Malatesta M, Peschiaroli A, Memmi EM, Zhang J, Antonov A, Green DR, Barlev NA, Garabadgiu AV, Zhou P, Melino G, Bernassola F.

Oncogene. 2013 Sep 26;32(39):4721-6. doi: 10.1038/onc.2012.463. Epub 2012 Oct 22.

PMID:
23085759
[PubMed - indexed for MEDLINE]
2.

Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis.

Jiang L, Rong R, Sheikh MS, Huang Y.

J Biol Chem. 2011 Mar 4;286(9):6971-8. doi: 10.1074/jbc.M110.186494. Epub 2011 Jan 4.

PMID:
21205828
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes.

Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H.

Cell Cycle. 2006 Aug;5(15):1719-29. Epub 2006 Aug 1.

PMID:
16861890
[PubMed - indexed for MEDLINE]
Free Article
4.

Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination.

Wu H, Zeinab RA, Flores ER, Leng RP.

Mol Cancer Res. 2011 Dec;9(12):1780-90. doi: 10.1158/1541-7786.MCR-11-0157. Epub 2011 Oct 12.

PMID:
21994467
[PubMed - indexed for MEDLINE]
Free Article
5.

Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.

Hu J, McCall CM, Ohta T, Xiong Y.

Nat Cell Biol. 2004 Oct;6(10):1003-9. Epub 2004 Sep 26.

PMID:
15448697
[PubMed - indexed for MEDLINE]
6.

The ubiquitin-protein ligase Itch regulates p73 stability.

Rossi M, De Laurenzi V, Munarriz E, Green DR, Liu YC, Vousden KH, Cesareni G, Melino G.

EMBO J. 2005 Feb 23;24(4):836-48. Epub 2005 Jan 27.

PMID:
15678106
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27.

Yan Y, Zhang X, Legerski RJ.

Cell Cycle. 2011 Dec 1;10(23):4098-109. doi: 10.4161/cc.10.23.18227. Epub 2011 Dec 1.

PMID:
22134138
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73.

Peschiaroli A, Scialpi F, Bernassola F, Pagano M, Melino G.

Oncogene. 2009 Sep 3;28(35):3157-66. doi: 10.1038/onc.2009.177. Epub 2009 Jul 6.

PMID:
19581926
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome.

Bondar T, Kalinina A, Khair L, Kopanja D, Nag A, Bagchi S, Raychaudhuri P.

Mol Cell Biol. 2006 Apr;26(7):2531-9.

PMID:
16537899
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

p73 cooperates with DNA damage agents to induce apoptosis in MCF7 cells in a p53-dependent manner.

Zhu J, Nozell S, Wang J, Jiang J, Zhou W, Chen X.

Oncogene. 2001 Jul 5;20(30):4050-7.

PMID:
11494133
[PubMed - indexed for MEDLINE]
Free Article
11.

TAp73 alpha increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation.

Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F.

Mol Cancer Res. 2008 Jan;6(1):64-77. doi: 10.1158/1541-7786.MCR-07-0005.

PMID:
18234963
[PubMed - indexed for MEDLINE]
Free Article
12.

Promoter specificity and stability control of the p53-related protein p73.

Lee CW, La Thangue NB.

Oncogene. 1999 Jul 22;18(29):4171-81.

PMID:
10435630
[PubMed - indexed for MEDLINE]
Free Article
13.

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.

Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y.

Genes Dev. 2008 Apr 1;22(7):866-71. doi: 10.1101/gad.1624008.

PMID:
18381890
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria.

John K, Alla V, Meier C, Pützer BM.

Cell Death Differ. 2011 May;18(5):874-86. doi: 10.1038/cdd.2010.153. Epub 2010 Dec 3. Erratum in: Cell Death Differ. 2012 Mar;19(3):552.

PMID:
21127500
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.

Lapi E, Di Agostino S, Donzelli S, Gal H, Domany E, Rechavi G, Pandolfi PP, Givol D, Strano S, Lu X, Blandino G.

Mol Cell. 2008 Dec 26;32(6):803-14. doi: 10.1016/j.molcel.2008.11.019.

PMID:
19111660
[PubMed - indexed for MEDLINE]
Free Article
16.

Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.

Ozaki T, Watanabe K, Nakagawa T, Miyazaki K, Takahashi M, Nakagawara A.

Oncogene. 2003 May 22;22(21):3231-42.

PMID:
12761493
[PubMed - indexed for MEDLINE]
17.

Depletion of the receptor for advanced glycation end products (RAGE) sensitizes towards apoptosis via p53 and p73 posttranslational regulation.

Brune M, Müller M, Melino G, Bierhaus A, Schilling T, Nawroth PP.

Oncogene. 2013 Mar 14;32(11):1460-8. doi: 10.1038/onc.2012.150. Epub 2012 Apr 30.

PMID:
22543586
[PubMed - indexed for MEDLINE]
18.

Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.

Sayan BS, Yang AL, Conforti F, Tucci P, Piro MC, Browne GJ, Agostini M, Bernardini S, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12877-82. doi: 10.1073/pnas.0911828107. Epub 2010 Jul 6.

PMID:
20615966
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.

Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapić-Otrin V.

Cancer Res. 2008 Jul 1;68(13):5014-22. doi: 10.1158/0008-5472.CAN-07-6162.

PMID:
18593899
[PubMed - indexed for MEDLINE]
Free Article
20.

Knocking down PML impairs p53 signaling transduction pathway and suppresses irradiation induced apoptosis in breast carcinoma cell MCF-7.

Bao-Lei T, Zhu-Zhong M, Yi S, Jun-Jie Q, Yan D, Hua L, Bin L, Guo-Wei Z, Zhi-Xian S.

J Cell Biochem. 2006 Feb 15;97(3):561-71.

PMID:
16215989
[PubMed - indexed for MEDLINE]

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