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Results: 1 to 20 of 98

1.

Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.

Alapafuja SO, Nikas SP, Bharathan IT, Shukla VG, Nasr ML, Bowman AL, Zvonok N, Li J, Shi X, Engen JR, Makriyannis A.

J Med Chem. 2012 Nov 26;55(22):10074-89. doi: 10.1021/jm301205j. Epub 2012 Nov 2.

PMID:
23083016
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.

Godlewski G, Alapafuja SO, Bátkai S, Nikas SP, Cinar R, Offertáler L, Osei-Hyiaman D, Liu J, Mukhopadhyay B, Harvey-White J, Tam J, Pacak K, Blankman JL, Cravatt BF, Makriyannis A, Kunos G.

Chem Biol. 2010 Nov 24;17(11):1256-66. doi: 10.1016/j.chembiol.2010.08.013.

PMID:
21095576
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor.

Deutsch DG, Lin S, Hill WA, Morse KL, Salehani D, Arreaza G, Omeir RL, Makriyannis A.

Biochem Biophys Res Commun. 1997 Feb 3;231(1):217-21.

PMID:
9070252
[PubMed - indexed for MEDLINE]
4.

Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.

Karbarz MJ, Luo L, Chang L, Tham CS, Palmer JA, Wilson SJ, Wennerholm ML, Brown SM, Scott BP, Apodaca RL, Keith JM, Wu J, Breitenbucher JG, Chaplan SR, Webb M.

Anesth Analg. 2009 Jan;108(1):316-29. doi: 10.1213/ane.0b013e31818c7cbd.

PMID:
19095868
[PubMed - indexed for MEDLINE]
5.

Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice.

Bashashati M, Storr MA, Nikas SP, Wood JT, Godlewski G, Liu J, Ho W, Keenan CM, Zhang H, Alapafuja SO, Cravatt BF, Lutz B, Mackie K, Kunos G, Patel KD, Makriyannis A, Davison JS, Sharkey KA.

Br J Pharmacol. 2012 Mar;165(5):1556-71. doi: 10.1111/j.1476-5381.2011.01644.x.

PMID:
21883147
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).

Min X, Thibault ST, Porter AC, Gustin DJ, Carlson TJ, Xu H, Lindstrom M, Xu G, Uyeda C, Ma Z, Li Y, Kayser F, Walker NP, Wang Z.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7379-84. doi: 10.1073/pnas.1016167108. Epub 2011 Apr 18.

PMID:
21502526
[PubMed - indexed for MEDLINE]
Free PMC Article
7.
8.

Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.

Wang X, Sarris K, Kage K, Zhang D, Brown SP, Kolasa T, Surowy C, El Kouhen OF, Muchmore SW, Brioni JD, Stewart AO.

J Med Chem. 2009 Jan 8;52(1):170-80. doi: 10.1021/jm801042a.

PMID:
19072118
[PubMed - indexed for MEDLINE]
9.

Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency.

Tian G, Paschetto KA, Gharahdaghi F, Gordon E, Wilkins DE, Luo X, Scott CW.

Biochemistry. 2011 Aug 16;50(32):6867-78. doi: 10.1021/bi200552p. Epub 2011 Jul 22.

PMID:
21728345
[PubMed - indexed for MEDLINE]
10.

Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.

Gustin DJ, Ma Z, Min X, Li Y, Hedberg C, Guimaraes C, Porter AC, Lindstrom M, Lester-Zeiner D, Xu G, Carlson TJ, Xiao S, Meleza C, Connors R, Wang Z, Kayser F.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2492-6. doi: 10.1016/j.bmcl.2011.02.052. Epub 2011 Feb 17.

PMID:
21392988
[PubMed - indexed for MEDLINE]
11.

Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors.

Dickason-Chesterfield AK, Kidd SR, Moore SA, Schaus JM, Liu B, Nomikos GG, Felder CC.

Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):407-23. Epub 2006 May 31.

PMID:
16736384
[PubMed - indexed for MEDLINE]
12.

A MBP-FAAH fusion protein as a tool to produce human and rat fatty acid amide hydrolase: expression and pharmacological comparison.

Labar G, Vliet FV, Wouters J, Lambert DM.

Amino Acids. 2008 Jan;34(1):127-33. Epub 2007 May 4.

PMID:
17476568
[PubMed - indexed for MEDLINE]
13.

Selective inhibitors of fatty acid amide hydrolase relative to neuropathy target esterase and acetylcholinesterase: toxicological implications.

Quistad GB, Sparks SE, Segall Y, Nomura DK, Casida JE.

Toxicol Appl Pharmacol. 2002 Feb 15;179(1):57-63.

PMID:
11884237
[PubMed - indexed for MEDLINE]
14.

Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.

Roughley SD, Browne H, Macias AT, Benwell K, Brooks T, D'Alessandro J, Daniels Z, Dugdale S, Francis G, Gibbons B, Hart T, Haymes T, Kennett G, Lightowler S, Matassova N, Mansell H, Merrett A, Misra A, Padfield A, Parsons R, Pratt R, Robertson A, Simmonite H, Tan K, Walls SB, Wong M.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):901-6. doi: 10.1016/j.bmcl.2011.12.032. Epub 2011 Dec 13.

PMID:
22209458
[PubMed - indexed for MEDLINE]
15.

Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.

Kono M, Matsumoto T, Kawamura T, Nishimura A, Kiyota Y, Oki H, Miyazaki J, Igaki S, Behnke CA, Shimojo M, Kori M.

Bioorg Med Chem. 2013 Jan 1;21(1):28-41. doi: 10.1016/j.bmc.2012.11.006. Epub 2012 Nov 15.

PMID:
23218778
[PubMed - indexed for MEDLINE]
16.

Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage.

Karanian DA, Karim SL, Wood JT, Williams JS, Lin S, Makriyannis A, Bahr BA.

J Pharmacol Exp Ther. 2007 Sep;322(3):1059-66. Epub 2007 Jun 1.

PMID:
17545313
[PubMed - indexed for MEDLINE]
Free Article
17.

Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity.

Karanian DA, Brown QB, Makriyannis A, Kosten TA, Bahr BA.

J Neurosci. 2005 Aug 24;25(34):7813-20.

PMID:
16120783
[PubMed - indexed for MEDLINE]
Free Article
18.

(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).

Holtfrerich A, Hanekamp W, Lehr M.

Eur J Med Chem. 2013 May;63:64-75. doi: 10.1016/j.ejmech.2013.01.050. Epub 2013 Feb 8.

PMID:
23455058
[PubMed - indexed for MEDLINE]
19.

Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues.

Otrubova K, Brown M, McCormick MS, Han GW, O'Neal ST, Cravatt BF, Stevens RC, Lichtman AH, Boger DL.

J Am Chem Soc. 2013 Apr 24;135(16):6289-99. doi: 10.1021/ja4014997. Epub 2013 Apr 12.

PMID:
23581831
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.

Boger DL, Miyauchi H, Du W, Hardouin C, Fecik RA, Cheng H, Hwang I, Hedrick MP, Leung D, Acevedo O, Guimarães CR, Jorgensen WL, Cravatt BF.

J Med Chem. 2005 Mar 24;48(6):1849-56.

PMID:
15771430
[PubMed - indexed for MEDLINE]
Free PMC Article
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