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Results: 1 to 20 of 104

1.

Conformational dynamics of full-length inducible human Hsp70 derived from microsecond molecular dynamics simulations in explicit solvent.

Nicolaï A, Delarue P, Senet P.

J Biomol Struct Dyn. 2013 Oct;31(10):1111-26. doi: 10.1080/07391102.2012.726190. Epub 2012 Oct 17.

PMID:
23075261
[PubMed - indexed for MEDLINE]
2.

Decipher the mechanisms of protein conformational changes induced by nucleotide binding through free-energy landscape analysis: ATP binding to Hsp70.

Nicolaï A, Delarue P, Senet P.

PLoS Comput Biol. 2013;9(12):e1003379. doi: 10.1371/journal.pcbi.1003379. Epub 2013 Dec 12.

PMID:
24348227
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Simulation of the opening and closing of Hsp70 chaperones by coarse-grained molecular dynamics.

Gołaś E, Maisuradze GG, Senet P, Ołdziej S, Czaplewski C, Scheraga HA, Liwo A.

J Chem Theory Comput. 2012 May 8;8(5):1750-1764. Epub 2012 Mar 15.

PMID:
22737044
[PubMed]
Free PMC Article
4.

Amide hydrogen exchange reveals conformational changes in hsp70 chaperones important for allosteric regulation.

Rist W, Graf C, Bukau B, Mayer MP.

J Biol Chem. 2006 Jun 16;281(24):16493-501. Epub 2006 Apr 13.

PMID:
16613854
[PubMed - indexed for MEDLINE]
Free Article
5.

Molecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulations.

Chiappori F, Merelli I, Colombo G, Milanesi L, Morra G.

PLoS Comput Biol. 2012;8(12):e1002844. doi: 10.1371/journal.pcbi.1002844. Epub 2012 Dec 27.

PMID:
23300424
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

NMR study of nucleotide-induced changes in the nucleotide binding domain of Thermus thermophilus Hsp70 chaperone DnaK: implications for the allosteric mechanism.

Revington M, Holder TM, Zuiderweg ER.

J Biol Chem. 2004 Aug 6;279(32):33958-67. Epub 2004 Jun 2.

PMID:
15175340
[PubMed - indexed for MEDLINE]
Free Article
7.

ATP-induced conformational changes in Hsp70: molecular dynamics and experimental validation of an in silico predicted conformation.

Woo HJ, Jiang J, Lafer EM, Sousa R.

Biochemistry. 2009 Dec 8;48(48):11470-7. doi: 10.1021/bi901256y.

PMID:
19883127
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP.

Qi R, Sarbeng EB, Liu Q, Le KQ, Xu X, Xu H, Yang J, Wong JL, Vorvis C, Hendrickson WA, Zhou L, Liu Q.

Nat Struct Mol Biol. 2013 Jul;20(7):900-7. doi: 10.1038/nsmb.2583. Epub 2013 May 26.

PMID:
23708608
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Allostery in Hsp70 chaperones is transduced by subdomain rotations.

Bhattacharya A, Kurochkin AV, Yip GN, Zhang Y, Bertelsen EB, Zuiderweg ER.

J Mol Biol. 2009 May 8;388(3):475-90. doi: 10.1016/j.jmb.2009.01.062. Epub 2009 Feb 4.

PMID:
19361428
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Structure and dynamics of the ATP-bound open conformation of Hsp70 chaperones.

Kityk R, Kopp J, Sinning I, Mayer MP.

Mol Cell. 2012 Dec 28;48(6):863-74. doi: 10.1016/j.molcel.2012.09.023. Epub 2012 Nov 1.

PMID:
23123194
[PubMed - indexed for MEDLINE]
Free Article
11.

Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state.

Shida M, Arakawa A, Ishii R, Kishishita S, Takagi T, Kukimoto-Niino M, Sugano S, Tanaka A, Shirouzu M, Yokoyama S.

Acta Crystallogr D Biol Crystallogr. 2010 Mar;66(Pt 3):223-32. doi: 10.1107/S0907444909053979. Epub 2010 Feb 12.

PMID:
20179333
[PubMed - indexed for MEDLINE]
12.

An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones.

Zhuravleva A, Clerico EM, Gierasch LM.

Cell. 2012 Dec 7;151(6):1296-307. doi: 10.1016/j.cell.2012.11.002.

PMID:
23217711
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Dominant-negative effects in prion diseases: insights from molecular dynamics simulations on mouse prion protein chimeras.

Cong X, Bongarzone S, Giachin G, Rossetti G, Carloni P, Legname G.

J Biomol Struct Dyn. 2013;31(8):829-40. doi: 10.1080/07391102.2012.712477. Epub 2012 Aug 30.

PMID:
22934595
[PubMed - indexed for MEDLINE]
14.

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate.

Bertelsen EB, Chang L, Gestwicki JE, Zuiderweg ER.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):8471-6. doi: 10.1073/pnas.0903503106. Epub 2009 May 13.

PMID:
19439666
[PubMed - indexed for MEDLINE]
Free PMC Article
15.
16.

Hsp70 chaperone dynamics and molecular mechanism.

Mayer MP.

Trends Biochem Sci. 2013 Oct;38(10):507-14. doi: 10.1016/j.tibs.2013.08.001. Epub 2013 Sep 5. Review.

PMID:
24012426
[PubMed - indexed for MEDLINE]
17.

Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate.

Zhang P, Leu JI, Murphy ME, George DL, Marmorstein R.

PLoS One. 2014 Jul 24;9(7):e103518. doi: 10.1371/journal.pone.0103518. eCollection 2014.

PMID:
25058147
[PubMed - in process]
Free PMC Article
18.

Crystal structures of the 70-kDa heat shock proteins in domain disjoining conformation.

Chang YW, Sun YJ, Wang C, Hsiao CD.

J Biol Chem. 2008 May 30;283(22):15502-11. doi: 10.1074/jbc.M708992200. Epub 2008 Apr 8.

PMID:
18400763
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange.

Arakawa A, Handa N, Ohsawa N, Shida M, Kigawa T, Hayashi F, Shirouzu M, Yokoyama S.

Structure. 2010 Mar 10;18(3):309-19. doi: 10.1016/j.str.2010.01.004.

PMID:
20223214
[PubMed - indexed for MEDLINE]
Free Article
20.

Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide.

Krukenberg KA, Böttcher UM, Southworth DR, Agard DA.

Protein Sci. 2009 Sep;18(9):1815-27. doi: 10.1002/pro.191.

PMID:
19554567
[PubMed - indexed for MEDLINE]
Free PMC Article

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