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Results: 1 to 20 of 80

1.

A common single-nucleotide variant in T is strongly associated with chordoma.

Pillay N, Plagnol V, Tarpey PS, Lobo SB, Presneau N, Szuhai K, Halai D, Berisha F, Cannon SR, Mead S, Kasperaviciute D, Palmen J, Talmud PJ, Kindblom LG, Amary MF, Tirabosco R, Flanagan AM.

Nat Genet. 2012 Nov;44(11):1185-7. doi: 10.1038/ng.2419. Epub 2012 Oct 14.

PMID:
23064415
[PubMed - indexed for MEDLINE]
2.

The brachyury Gly177Asp SNP is not associated with a risk of skull base chordoma in the Chinese population.

Wu Z, Wang K, Wang L, Feng J, Hao S, Tian K, Zhang L, Jia G, Wan H, Zhang J.

Int J Mol Sci. 2013 Oct 25;14(11):21258-65. doi: 10.3390/ijms141121258.

PMID:
24232574
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

'The chicken or the egg?' dilemma strikes back for the controlling mechanism in chordoma(#).

Szuhai K, Hogendoorn PC.

J Pathol. 2012 Nov;228(3):261-5. doi: 10.1002/path.4102.

PMID:
22952146
[PubMed - indexed for MEDLINE]
4.

Brachyury and chordoma: the chondroid-chordoid dilemma resolved?

Romeo S, Hogendoorn PC.

J Pathol. 2006 Jun;209(2):143-6.

PMID:
16604512
[PubMed - indexed for MEDLINE]
5.

T (brachyury) gene duplication confers major susceptibility to familial chordoma.

Yang XR, Ng D, Alcorta DA, Liebsch NJ, Sheridan E, Li S, Goldstein AM, Parry DM, Kelley MJ.

Nat Genet. 2009 Nov;41(11):1176-8. doi: 10.1038/ng.454. Epub 2009 Oct 4.

PMID:
19801981
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.

Nelson AC, Pillay N, Henderson S, Presneau N, Tirabosco R, Halai D, Berisha F, Flicek P, Stemple DL, Stern CD, Wardle FC, Flanagan AM.

J Pathol. 2012 Nov;228(3):274-85. doi: 10.1002/path.4082. Epub 2012 Sep 26.

PMID:
22847733
[PubMed - indexed for MEDLINE]
7.

Novel therapeutic targets in chordoma.

Bydon M, Papadimitriou K, Witham T, Wolinsky JP, Bydon A, Sciubba D, Gokaslan Z.

Expert Opin Ther Targets. 2012 Nov;16(11):1139-43. doi: 10.1517/14728222.2012.714772. Epub 2012 Aug 4. Review.

PMID:
22860993
[PubMed - indexed for MEDLINE]
8.

Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

Presneau N, Shalaby A, Ye H, Pillay N, Halai D, Idowu B, Tirabosco R, Whitwell D, Jacques TS, Kindblom LG, Brüderlein S, Möller P, Leithner A, Liegl B, Amary FM, Athanasou NN, Hogendoorn PC, Mertens F, Szuhai K, Flanagan AM.

J Pathol. 2011 Feb;223(3):327-35. doi: 10.1002/path.2816. Epub 2010 Nov 24.

PMID:
21171078
[PubMed - indexed for MEDLINE]
9.

From notochord formation to hereditary chordoma: the many roles of Brachyury.

Nibu Y, José-Edwards DS, Di Gregorio A.

Biomed Res Int. 2013;2013:826435. doi: 10.1155/2013/826435. Epub 2013 Mar 31. Review.

PMID:
23662285
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target.

Hsu W, Mohyeldin A, Shah SR, ap Rhys CM, Johnson LF, Sedora-Roman NI, Kosztowski TA, Awad OA, McCarthy EF, Loeb DM, Wolinsky JP, Gokaslan ZL, Quiñones-Hinojosa A.

J Neurosurg. 2011 Oct;115(4):760-9. doi: 10.3171/2011.5.JNS11185. Epub 2011 Jun 24.

PMID:
21699479
[PubMed - indexed for MEDLINE]
11.

Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma.

Kelley MJ, Shi J, Ballew B, Hyland PL, Li WQ, Rotunno M, Alcorta DA, Liebsch NJ, Mitchell J, Bass S, Roberson D, Boland J, Cullen M, He J, Burdette L, Yeager M, Chanock SJ, Parry DM, Goldstein AM, Yang XR.

Hum Genet. 2014 Jul 4. [Epub ahead of print]

PMID:
24990759
[PubMed - as supplied by publisher]
12.

Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas.

Shalaby AA, Presneau N, Idowu BD, Thompson L, Briggs TR, Tirabosco R, Diss TC, Flanagan AM.

Mod Pathol. 2009 Aug;22(8):996-1005. doi: 10.1038/modpathol.2009.63. Epub 2009 May 1.

PMID:
19407855
[PubMed - indexed for MEDLINE]
Free Article
13.

P63 does not regulate brachyury expression in human chordomas and osteosarcomas.

Pillay N, Amary FM, Berisha F, Tirabosco R, Flanagan AM.

Histopathology. 2011 Nov;59(5):1025-7. doi: 10.1111/j.1365-2559.2011.03973.x. Epub 2011 Oct 18. No abstract available.

PMID:
22007675
[PubMed - indexed for MEDLINE]
14.

T locus shows no evidence for linkage disequilibrium or mutation in American Caucasian neural tube defect families.

Speer MC, Melvin EC, Viles KD, Bauer KA, Rampersaud E, Drake C, George TM, Enterline DS, Mackey JF, Worley G, Gilbert JR, Nye JS; NTD Collaborative Group. Neural Tube Defects.

Am J Med Genet. 2002 Jul 1;110(3):215-8.

PMID:
12116228
[PubMed - indexed for MEDLINE]
15.

Genome-wide association studies of the PR interval in African Americans.

Smith JG, Magnani JW, Palmer C, Meng YA, Soliman EZ, Musani SK, Kerr KF, Schnabel RB, Lubitz SA, Sotoodehnia N, Redline S, Pfeufer A, Müller M, Evans DS, Nalls MA, Liu Y, Newman AB, Zonderman AB, Evans MK, Deo R, Ellinor PT, Paltoo DN, Newton-Cheh C, Benjamin EJ, Mehra R, Alonso A, Heckbert SR, Fox ER; Candidate-gene Association Resource (CARe) Consortium.

PLoS Genet. 2011 Feb 10;7(2):e1001304. doi: 10.1371/journal.pgen.1001304.

PMID:
21347284
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.

Shalaby A, Presneau N, Ye H, Halai D, Berisha F, Idowu B, Leithner A, Liegl B, Briggs TR, Bacsi K, Kindblom LG, Athanasou N, Amary MF, Hogendoorn PC, Tirabosco R, Flanagan AM.

J Pathol. 2011 Feb;223(3):336-46. doi: 10.1002/path.2818. Epub 2010 Dec 10.

PMID:
21171079
[PubMed - indexed for MEDLINE]
17.

Molecular and clinical risk factors for recurrence of skull base chordomas: gain on chromosome 2p, expression of brachyury, and lack of irradiation negatively correlate with patient prognosis.

Kitamura Y, Sasaki H, Kimura T, Miwa T, Takahashi S, Kawase T, Yoshida K.

J Neuropathol Exp Neurol. 2013 Sep;72(9):816-23. doi: 10.1097/NEN.0b013e3182a065d0.

PMID:
23965741
[PubMed - indexed for MEDLINE]
18.

Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue.

Tirabosco R, Mangham DC, Rosenberg AE, Vujovic S, Bousdras K, Pizzolitto S, De Maglio G, den Bakker MA, Di Francesco L, Kalil RK, Athanasou NA, O'Donnell P, McCarthy EF, Flanagan AM.

Am J Surg Pathol. 2008 Apr;32(4):572-80. doi: 10.1097/PAS.0b013e31815b693a.

PMID:
18301055
[PubMed - indexed for MEDLINE]
19.

The association analysis of TBX6 polymorphism with susceptibility to congenital scoliosis in a Chinese Han population.

Fei Q, Wu Z, Wang H, Zhou X, Wang N, Ding Y, Wang Y, Qiu G.

Spine (Phila Pa 1976). 2010 Apr 20;35(9):983-8. doi: 10.1097/BRS.0b013e3181bc963c.

PMID:
20228709
[PubMed - indexed for MEDLINE]
20.

Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.

Tantisira KG, Damask A, Szefler SJ, Schuemann B, Markezich A, Su J, Klanderman B, Sylvia J, Wu R, Martinez F, Boushey HA, Chinchilli VM, Mauger D, Weiss ST, Israel E; SHARP Investigators.

Am J Respir Crit Care Med. 2012 Jun 15;185(12):1286-91. doi: 10.1164/rccm.201111-2061OC. Epub 2012 Apr 26.

PMID:
22538805
[PubMed - indexed for MEDLINE]
Free PMC Article

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