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Items: 1 to 20 of 99

1.

Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay.

Höing S, Rudhard Y, Reinhardt P, Glatza M, Stehling M, Wu G, Peiker C, Böcker A, Parga JA, Bunk E, Schwamborn JC, Slack M, Sterneckert J, Schöler HR.

Cell Stem Cell. 2012 Nov 2;11(5):620-32. doi: 10.1016/j.stem.2012.07.005. Epub 2012 Oct 11.

2.

3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity.

Zhang W, Qin L, Wang T, Wei SJ, Gao HM, Liu J, Wilson B, Liu B, Zhang W, Kim HC, Hong JS.

FASEB J. 2005 Mar;19(3):395-7. Epub 2004 Dec 13.

3.

Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia.

Zhao W, Xie W, Xiao Q, Beers DR, Appel SH.

J Neurochem. 2006 Nov;99(4):1176-87. Epub 2006 Oct 2.

4.

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.

Thorne N, Malik N, Shah S, Zhao J, Class B, Aguisanda F, Southall N, Xia M, McKew JC, Rao M, Zheng W.

Stem Cells Transl Med. 2016 May;5(5):613-27. doi: 10.5966/sctm.2015-0170. Epub 2016 Mar 31.

PMID:
27034412
5.

Surfactin exhibits neuroprotective effects by inhibiting amyloid β-mediated microglial activation.

Park SY, Kim JH, Lee SJ, Kim Y.

Neurotoxicology. 2013 Sep;38:115-23. doi: 10.1016/j.neuro.2013.07.004. Epub 2013 Jul 29.

PMID:
23906708
6.

Small molecule glutaminase inhibitors block glutamate release from stimulated microglia.

Thomas AG, O'Driscoll CM, Bressler J, Kaufmann W, Rojas CJ, Slusher BS.

Biochem Biophys Res Commun. 2014 Jan 3;443(1):32-6. doi: 10.1016/j.bbrc.2013.11.043. Epub 2013 Nov 19.

7.

Aspirin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity in primary midbrain cultures.

Wang F, Zhai H, Huang L, Li H, Xu Y, Qiao X, Sun S, Wu Y.

J Mol Neurosci. 2012 Jan;46(1):153-61. doi: 10.1007/s12031-011-9541-3. Epub 2011 May 17.

PMID:
21584653
8.

Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity.

Liang J, Takeuchi H, Doi Y, Kawanokuchi J, Sonobe Y, Jin S, Yawata I, Li H, Yasuoka S, Mizuno T, Suzumura A.

Brain Res. 2008 May 19;1210:11-9. doi: 10.1016/j.brainres.2008.03.012. Epub 2008 Mar 20.

PMID:
18410911
9.

Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation.

Liu Y, Qin L, Li G, Zhang W, An L, Liu B, Hong JS.

J Pharmacol Exp Ther. 2003 Apr;305(1):212-8.

11.

Microglia is activated by astrocytes in trimethyltin intoxication.

Röhl C, Sievers J.

Toxicol Appl Pharmacol. 2005 Apr 1;204(1):36-45.

PMID:
15781292
12.

Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-dependent HO-1 pathway.

Kang CH, Choi YH, Moon SK, Kim WJ, Kim GY.

Int Immunopharmacol. 2013 Nov;17(3):808-13. doi: 10.1016/j.intimp.2013.09.009. Epub 2013 Sep 25.

PMID:
24076371
13.

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.

Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A.

J Neurochem. 2009 Oct;111(2):332-43. doi: 10.1111/j.1471-4159.2009.06347.x. Epub 2009 Aug 18.

14.

Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.

Foresti R, Bains SK, Pitchumony TS, de Castro Brás LE, Drago F, Dubois-Randé JL, Bucolo C, Motterlini R.

Pharmacol Res. 2013 Oct;76:132-48. doi: 10.1016/j.phrs.2013.07.010. Epub 2013 Aug 11.

PMID:
23942037
15.

Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS.

Kadoyama K, Funakoshi H, Ohya W, Nakamura T.

Neurosci Res. 2007 Dec;59(4):446-56. Epub 2007 Aug 31.

PMID:
17935811
16.
17.

Salvianolic acid B attenuates toxin-induced neuronal damage via Nrf2-dependent glial cells-mediated protective activity in Parkinson's disease models.

Zhou J, Qu XD, Li ZY, Wei-Ji, Liu Q, Ma YH, He JJ.

PLoS One. 2014 Jul 3;9(7):e101668. doi: 10.1371/journal.pone.0101668. eCollection 2014.

18.

Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway.

Pais TF, Figueiredo C, Peixoto R, Braz MH, Chatterjee S.

J Neuroinflammation. 2008 Oct 9;5:43. doi: 10.1186/1742-2094-5-43.

19.

Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity.

Zhang D, Hu X, Wei SJ, Liu J, Gao H, Qian L, Wilson B, Liu G, Hong JS.

J Neuroinflammation. 2008 May 28;5:21. doi: 10.1186/1742-2094-5-21.

20.

Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition.

Park SY, Kim YH, Park G.

Neurosci Lett. 2015 Nov 16;609:129-36. doi: 10.1016/j.neulet.2015.10.022. Epub 2015 Oct 22.

PMID:
26472707
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