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Results: 1 to 20 of 135

1.

Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function.

Bernardo BC, Gao XM, Winbanks CE, Boey EJ, Tham YK, Kiriazis H, Gregorevic P, Obad S, Kauppinen S, Du XJ, Lin RC, McMullen JR.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17615-20. doi: 10.1073/pnas.1206432109. Epub 2012 Oct 9.

PMID:
23047694
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy.

Bernardo BC, Gao XM, Tham YK, Kiriazis H, Winbanks CE, Ooi JY, Boey EJ, Obad S, Kauppinen S, Gregorevic P, Du XJ, Lin RC, McMullen JR.

PLoS One. 2014 Feb 27;9(2):e90337. doi: 10.1371/journal.pone.0090337. eCollection 2014.

PMID:
24587330
[PubMed - in process]
Free PMC Article
3.

Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver.

Elmén J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind-Thomsen A, Hedtjärn M, Hansen JB, Hansen HF, Straarup EM, McCullagh K, Kearney P, Kauppinen S.

Nucleic Acids Res. 2008 Mar;36(4):1153-62. Epub 2007 Dec 23.

PMID:
18158304
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.

Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM.

Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840.

PMID:
24259050
[PubMed - indexed for MEDLINE]
5.

Inhibition of miR-15 protects against cardiac ischemic injury.

Hullinger TG, Montgomery RL, Seto AG, Dickinson BA, Semus HM, Lynch JM, Dalby CM, Robinson K, Stack C, Latimer PA, Hare JM, Olson EN, van Rooij E.

Circ Res. 2012 Jan 6;110(1):71-81. doi: 10.1161/CIRCRESAHA.111.244442. Epub 2011 Nov 3.

PMID:
22052914
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

LNA-mediated microRNA silencing in non-human primates.

Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M, Hansen HF, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, Kauppinen S.

Nature. 2008 Apr 17;452(7189):896-9. doi: 10.1038/nature06783. Epub 2008 Mar 26.

PMID:
18368051
[PubMed - indexed for MEDLINE]
7.

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice.

Patrick DM, Montgomery RL, Qi X, Obad S, Kauppinen S, Hill JA, van Rooij E, Olson EN.

J Clin Invest. 2010 Nov;120(11):3912-6. doi: 10.1172/JCI43604. Epub 2010 Oct 18.

PMID:
20978354
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

miR-1 exacerbates cardiac ischemia-reperfusion injury in mouse models.

Pan Z, Sun X, Ren J, Li X, Gao X, Lu C, Zhang Y, Sun H, Wang Y, Wang H, Wang J, Xie L, Lu Y, Yang B.

PLoS One. 2012;7(11):e50515. doi: 10.1371/journal.pone.0050515. Epub 2012 Nov 30.

PMID:
23226300
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model.

Hinkel R, Penzkofer D, Zühlke S, Fischer A, Husada W, Xu QF, Baloch E, van Rooij E, Zeiher AM, Kupatt C, Dimmeler S.

Circulation. 2013 Sep 3;128(10):1066-75. doi: 10.1161/CIRCULATIONAHA.113.001904. Epub 2013 Jul 29.

PMID:
23897866
[PubMed - indexed for MEDLINE]
10.

Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure.

Montgomery RL, Hullinger TG, Semus HM, Dickinson BA, Seto AG, Lynch JM, Stack C, Latimer PA, Olson EN, van Rooij E.

Circulation. 2011 Oct 4;124(14):1537-47. doi: 10.1161/CIRCULATIONAHA.111.030932. Epub 2011 Sep 6.

PMID:
21900086
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Overexpression of microRNA-1 impairs cardiac contractile function by damaging sarcomere assembly.

Ai J, Zhang R, Gao X, Niu HF, Wang N, Xu Y, Li Y, Ma N, Sun LH, Pan ZW, Li WM, Yang BF.

Cardiovasc Res. 2012 Aug 1;95(3):385-93. doi: 10.1093/cvr/cvs196. Epub 2012 Jun 18.

PMID:
22719074
[PubMed - indexed for MEDLINE]
Free Article
12.

PEI-complexed LNA antiseeds as miRNA inhibitors.

Thomas M, Lange-Grünweller K, Dayyoub E, Bakowsky U, Weirauch U, Aigner A, Hartmann RK, Grünweller A.

RNA Biol. 2012 Aug;9(8):1088-98. doi: 10.4161/rna.21165. Epub 2012 Aug 1.

PMID:
22894918
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression.

Murphy BL, Obad S, Bihannic L, Ayrault O, Zindy F, Kauppinen S, Roussel MF.

Cancer Res. 2013 Dec 1;73(23):7068-78. doi: 10.1158/0008-5472.CAN-13-0927. Epub 2013 Oct 21.

PMID:
24145352
[PubMed - indexed for MEDLINE]
14.

Micro-RNA-34a contributes to the impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease.

Xu Q, Seeger FH, Castillo J, Iekushi K, Boon RA, Farcas R, Manavski Y, Li YG, Assmus B, Zeiher AM, Dimmeler S.

J Am Coll Cardiol. 2012 Jun 5;59(23):2107-17. doi: 10.1016/j.jacc.2012.02.033.

PMID:
22651868
[PubMed - indexed for MEDLINE]
Free Article
15.

MicroRNA-1 transfected embryonic stem cells enhance cardiac myocyte differentiation and inhibit apoptosis by modulating the PTEN/Akt pathway in the infarcted heart.

Glass C, Singla DK.

Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2038-49. doi: 10.1152/ajpheart.00271.2011. Epub 2011 Aug 19.

PMID:
21856911
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and miR-206-mediated inhibition of TIMP-3.

Limana F, Esposito G, D'Arcangelo D, Di Carlo A, Romani S, Melillo G, Mangoni A, Bertolami C, Pompilio G, Germani A, Capogrossi MC.

PLoS One. 2011;6(6):e19845. doi: 10.1371/journal.pone.0019845. Epub 2011 Jun 22.

PMID:
21731608
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

MicroRNA-328 as a regulator of cardiac hypertrophy.

Li C, Li X, Gao X, Zhang R, Zhang Y, Liang H, Xu C, Du W, Zhang Y, Liu X, Ma N, Xu Z, Wang L, Chen X, Lu Y, Ju J, Yang B, Shan H.

Int J Cardiol. 2014 May 1;173(2):268-76. doi: 10.1016/j.ijcard.2014.02.035. Epub 2014 Feb 28.

PMID:
24631114
[PubMed - in process]
18.

Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response.

Shimano M, Ouchi N, Shibata R, Ohashi K, Pimentel DR, Murohara T, Walsh K.

J Mol Cell Cardiol. 2010 Aug;49(2):210-20. doi: 10.1016/j.yjmcc.2010.02.021. Epub 2010 Mar 4.

PMID:
20206634
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Bone marrow progenitor cell therapy-mediated paracrine regulation of cardiac miRNA-155 modulates fibrotic response in diabetic hearts.

Kishore R, Verma SK, Mackie AR, Vaughan EE, Abramova TV, Aiko I, Krishnamurthy P.

PLoS One. 2013;8(4):e60161. doi: 10.1371/journal.pone.0060161. Epub 2013 Apr 1.

PMID:
23560074
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival.

Knezevic I, Patel A, Sundaresan NR, Gupta MP, Solaro RJ, Nagalingam RS, Gupta M.

J Biol Chem. 2012 Apr 13;287(16):12913-26. doi: 10.1074/jbc.M111.331751. Epub 2012 Feb 24.

PMID:
22367207
[PubMed - indexed for MEDLINE]
Free PMC Article

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