Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 95

1.

Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.

Favia AD, Habrant D, Scarpelli R, Migliore M, Albani C, Bertozzi SM, Dionisi M, Tarozzo G, Piomelli D, Cavalli A, De Vivo M.

J Med Chem. 2012 Oct 25;55(20):8807-26. doi: 10.1021/jm3011146. Epub 2012 Oct 8.

PMID:
23043222
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase.

Bertolacci L, Romeo E, Veronesi M, Magotti P, Albani C, Dionisi M, Lambruschini C, Scarpelli R, Cavalli A, De Vivo M, Piomelli D, Garau G.

J Am Chem Soc. 2013 Jan 9;135(1):22-5. doi: 10.1021/ja308733u. Epub 2012 Dec 21.

PMID:
23240907
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Amide derivatives of [5-chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl]acetic acids as potential analgesic and anti-inflammatory compounds.

Banoglu E, Okçelik B, Kupeli E, Unlü S, Yeşilada E, Amat M, Caturla JF, Sahin MF.

Arch Pharm (Weinheim). 2003 Jul;336(4-5):251-7.

PMID:
12916060
[PubMed - indexed for MEDLINE]
4.

Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen.

Cipriano M, Björklund E, Wilson AA, Congiu C, Onnis V, Fowler CJ.

Eur J Pharmacol. 2013 Nov 15;720(1-3):383-90. doi: 10.1016/j.ejphar.2013.09.065. Epub 2013 Oct 8.

PMID:
24120370
[PubMed - indexed for MEDLINE]
5.

Investigations of new pyridazinone derivatives for the synthesis of potent analgesic and anti-inflammatory compounds with cyclooxygenase inhibitory activity.

Okçelik B, Unlü S, Banoglu E, Küpeli E, Yeşilada E, Sahin MF.

Arch Pharm (Weinheim). 2003 Sep;336(9):406-12.

PMID:
14528488
[PubMed - indexed for MEDLINE]
6.

Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.

Kalgutkar AS, Marnett AB, Crews BC, Remmel RP, Marnett LJ.

J Med Chem. 2000 Jul 27;43(15):2860-70.

PMID:
10956194
[PubMed - indexed for MEDLINE]
7.

Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors.

Onnis V, Congiu C, Björklund E, Hempel F, Söderström E, Fowler CJ.

J Med Chem. 2010 Mar 11;53(5):2286-98. doi: 10.1021/jm901891p.

PMID:
20143779
[PubMed - indexed for MEDLINE]
8.

Design and synthesis of 2-phenoxynicotinic acid hydrazides as anti-inflammatory and analgesic agents.

Moradi A, Navidpour L, Amini M, Sadeghian H, Shadnia H, Firouzi O, Miri R, Ebrahimi SE, Abdollahi M, Zahmatkesh MH, Shafiee A.

Arch Pharm (Weinheim). 2010 Sep;343(9):509-18. doi: 10.1002/ardp.200900294.

PMID:
20806271
[PubMed - indexed for MEDLINE]
9.

Structure based design of novel irreversible FAAH inhibitors.

Wang JL, Bowen SJ, Schweitzer BA, Madsen HM, McDonald J, Pelc MJ, Tenbrink RE, Beidler D, Thorarensen A.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5970-4. doi: 10.1016/j.bmcl.2009.07.101. Epub 2009 Jul 25.

PMID:
19765986
[PubMed - indexed for MEDLINE]
10.

Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.

Almansa C, Alfón J, de Arriba AF, Cavalcanti FL, Escamilla I, Gómez LA, Miralles A, Soliva R, Bartrolí J, Carceller E, Merlos M, García-Rafanell J.

J Med Chem. 2003 Jul 31;46(16):3463-75.

PMID:
12877584
[PubMed - indexed for MEDLINE]
11.

New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.

Janusz JM, Young PA, Ridgeway JM, Scherz MW, Enzweiler K, Wu LI, Gan L, Chen J, Kellstein DE, Green SA, Tulich JL, Rosario-Jansen T, Magrisso IJ, Wehmeyer KR, Kuhlenbeck DL, Eichhold TH, Dobson RL.

J Med Chem. 1998 Aug 27;41(18):3515-29.

PMID:
9719605
[PubMed - indexed for MEDLINE]
12.

4-substituted 1,5-diarylpyrazole, analogues of celecoxib: synthesis and preliminary evaluation of biological properties.

Menozzi G, Merello L, Fossa P, Mosti L, Piana A, Mattioli F.

Farmaco. 2003 Sep;58(9):795-808.

PMID:
13679172
[PubMed - indexed for MEDLINE]
13.

1-(3-biaryloxy-2-oxopropyl)indole-5-carboxylic acids and related compounds as dual inhibitors of human cytosolic phospholipase A2α and fatty acid amide hydrolase.

Zahov S, Drews A, Hess M, Schulze Elfringhoff A, Lehr M.

ChemMedChem. 2011 Mar 7;6(3):544-9. doi: 10.1002/cmdc.201000473. Epub 2011 Jan 21.

PMID:
21259444
[PubMed - indexed for MEDLINE]
14.

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.

Boger DL, Miyauchi H, Du W, Hardouin C, Fecik RA, Cheng H, Hwang I, Hedrick MP, Leung D, Acevedo O, Guimarães CR, Jorgensen WL, Cravatt BF.

J Med Chem. 2005 Mar 24;48(6):1849-56.

PMID:
15771430
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.

Biava M, Porretta GC, Poce G, Supino S, Manetti F, Forli S, Botta M, Sautebin L, Rossi A, Pergola C, Ghelardini C, Norcini M, Makovec F, Giordani A, Anzellotti P, Cirilli R, Ferretti R, Gallinella B, La Torre F, Anzini M, Patrignani P.

Bioorg Med Chem. 2008 Sep 1;16(17):8072-81. doi: 10.1016/j.bmc.2008.07.058. Epub 2008 Jul 24.

PMID:
18752957
[PubMed - indexed for MEDLINE]
16.

A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity.

Magrioti V, Naxakis G, Hadjipavlou-Litina D, Makriyannis A, Kokotos G.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5424-7. doi: 10.1016/j.bmcl.2008.09.039. Epub 2008 Sep 12.

PMID:
18819796
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.

Kalgutkar AS, Rowlinson SW, Crews BC, Marnett LJ.

Bioorg Med Chem Lett. 2002 Feb 25;12(4):521-4.

PMID:
11844663
[PubMed - indexed for MEDLINE]
18.

Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain.

Meyers MJ, Long SA, Pelc MJ, Wang JL, Bowen SJ, Schweitzer BA, Wilcox MV, McDonald J, Smith SE, Foltin S, Rumsey J, Yang YS, Walker MC, Kamtekar S, Beidler D, Thorarensen A.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6545-53. doi: 10.1016/j.bmcl.2011.08.048. Epub 2011 Aug 19.

PMID:
21924613
[PubMed - indexed for MEDLINE]
19.

Enantioselective pharmacokinetics and cyclo-oxygenase inhibition of carprofen and carprofen enantiomers in sheep.

Cheng Z, Nolan A, Monteiro A, McKellar Q.

J Vet Pharmacol Ther. 2003 Oct;26(5):391-4. No abstract available.

PMID:
14633193
[PubMed - indexed for MEDLINE]
20.

Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.

Kono M, Matsumoto T, Kawamura T, Nishimura A, Kiyota Y, Oki H, Miyazaki J, Igaki S, Behnke CA, Shimojo M, Kori M.

Bioorg Med Chem. 2013 Jan 1;21(1):28-41. doi: 10.1016/j.bmc.2012.11.006. Epub 2012 Nov 15.

PMID:
23218778
[PubMed - indexed for MEDLINE]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk