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Results: 1 to 20 of 105

1.

Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation.

D'Orlando O, Zhao F, Kasper B, Orinska Z, Müller J, Hermans-Borgmeyer I, Griffiths GM, Zur Stadt U, Bulfone-Paus S.

Eur J Immunol. 2013 Jan;43(1):194-208. doi: 10.1002/eji.201142343. Epub 2012 Dec 12.

PMID:
23042080
[PubMed - indexed for MEDLINE]
2.

Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease.

Kögl T, Müller J, Jessen B, Schmitt-Graeff A, Janka G, Ehl S, zur Stadt U, Aichele P.

Blood. 2013 Jan 24;121(4):604-13. doi: 10.1182/blood-2012-07-441139. Epub 2012 Nov 27.

PMID:
23190531
[PubMed - indexed for MEDLINE]
Free Article
3.

Unusual functional manifestations of a novel STX11 frameshift mutation in two infants with familial hemophagocytic lymphohistiocytosis type 4 (FHL4).

Macartney CA, Weitzman S, Wood SM, Bansal D, Steele M, Meeths M, Abdelhaleem M, Bryceson YT.

Pediatr Blood Cancer. 2011 Apr;56(4):654-7. doi: 10.1002/pbc.22676. Epub 2010 Dec 27.

PMID:
21298754
[PubMed - indexed for MEDLINE]
4.

Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.

Sepulveda FE, Debeurme F, Ménasché G, Kurowska M, Côte M, Pachlopnik Schmid J, Fischer A, de Saint Basile G.

Blood. 2013 Jan 24;121(4):595-603. doi: 10.1182/blood-2012-07-440339. Epub 2012 Nov 16.

PMID:
23160464
[PubMed - indexed for MEDLINE]
Free Article
5.

Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production.

Chiang SC, Theorell J, Entesarian M, Meeths M, Mastafa M, Al-Herz W, Frisk P, Gilmour KC, Ifversen M, Langenskiöld C, Machaczka M, Naqvi A, Payne J, Perez-Martinez A, Sabel M, Unal E, Unal S, Winiarski J, Nordenskjöld M, Ljunggren HG, Henter JI, Bryceson YT.

Blood. 2013 Feb 21;121(8):1345-56. doi: 10.1182/blood-2012-07-442558. Epub 2013 Jan 2.

PMID:
23287865
[PubMed - indexed for MEDLINE]
Free Article
6.

The exocytosis of lytic granules is impaired in Vti1b- or Vamp8-deficient CTL leading to a reduced cytotoxic activity following antigen-specific activation.

Dressel R, Elsner L, Novota P, Kanwar N, Fischer von Mollard G.

J Immunol. 2010 Jul 15;185(2):1005-14. doi: 10.4049/jimmunol.1000770. Epub 2010 Jun 11.

PMID:
20543108
[PubMed - indexed for MEDLINE]
Free Article
7.

Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases.

Rohr J, Beutel K, Maul-Pavicic A, Vraetz T, Thiel J, Warnatz K, Bondzio I, Gross-Wieltsch U, Schündeln M, Schütz B, Woessmann W, Groll AH, Strahm B, Pagel J, Speckmann C, Janka G, Griffiths G, Schwarz K, zur Stadt U, Ehl S.

Haematologica. 2010 Dec;95(12):2080-7. doi: 10.3324/haematol.2010.029389. Epub 2010 Sep 7.

PMID:
20823128
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Syntaxin binding mechanism and disease-causing mutations in Munc18-2.

Hackmann Y, Graham SC, Ehl S, Höning S, Lehmberg K, Aricò M, Owen DJ, Griffiths GM.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4482-91. doi: 10.1073/pnas.1313474110. Epub 2013 Nov 5.

PMID:
24194549
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients.

Bryceson YT, Rudd E, Zheng C, Edner J, Ma D, Wood SM, Bechensteen AG, Boelens JJ, Celkan T, Farah RA, Hultenby K, Winiarski J, Roche PA, Nordenskjöld M, Henter JI, Long EO, Ljunggren HG.

Blood. 2007 Sep 15;110(6):1906-15. Epub 2007 May 24.

PMID:
17525286
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages.

Offenhäuser C, Lei N, Roy S, Collins BM, Stow JL, Murray RZ.

Traffic. 2011 Jun;12(6):762-73. doi: 10.1111/j.1600-0854.2011.01189.x. Epub 2011 Apr 8.

PMID:
21388490
[PubMed - indexed for MEDLINE]
11.

Syntaxin 11 marks a distinct intracellular compartment recruited to the immunological synapse of NK cells to colocalize with cytotoxic granules.

Dabrazhynetskaya A, Ma J, Guerreiro-Cacais AO, Arany Z, Rudd E, Henter JI, Karre K, Levitskaya J, Levitsky V.

J Cell Mol Med. 2012 Jan;16(1):129-41. doi: 10.1111/j.1582-4934.2011.01280.x.

PMID:
21342435
[PubMed - indexed for MEDLINE]
12.

STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America.

Marsh RA, Satake N, Biroschak J, Jacobs T, Johnson J, Jordan MB, Bleesing JJ, Filipovich AH, Zhang K.

Pediatr Blood Cancer. 2010 Jul 15;55(1):134-40. doi: 10.1002/pbc.22499.

PMID:
20486178
[PubMed - indexed for MEDLINE]
13.

Spectrum, and clinical and functional implications of UNC13D mutations in familial haemophagocytic lymphohistiocytosis.

Rudd E, Bryceson YT, Zheng C, Edner J, Wood SM, Ramme K, Gavhed S, Gürgey A, Hellebostad M, Bechensteen AG, Ljunggren HG, Fadeel B, Nordenskjöld M, Henter JI.

J Med Genet. 2008 Mar;45(3):134-41. Epub 2007 Nov 9.

PMID:
17993578
[PubMed - indexed for MEDLINE]
14.

Deciphering the syntax of cytotoxic lymphocyte degranulation.

Lopez JA, Voskoboinik I.

Eur J Immunol. 2013 Jan;43(1):46-9. doi: 10.1002/eji.201243221.

PMID:
23322694
[PubMed - indexed for MEDLINE]
15.

Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity.

Sieni E, Cetica V, Mastrodicasa E, Pende D, Moretta L, Griffiths G, Aricò M.

Cell Mol Life Sci. 2012 Jan;69(1):29-40. doi: 10.1007/s00018-011-0835-y. Epub 2011 Oct 12. Review.

PMID:
21990010
[PubMed - indexed for MEDLINE]
16.

Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A.

Zur Stadt U, Beutel K, Kolberg S, Schneppenheim R, Kabisch H, Janka G, Hennies HC.

Hum Mutat. 2006 Jan;27(1):62-8.

PMID:
16278825
[PubMed - indexed for MEDLINE]
17.

Defects in neutrophil granule mobilization and bactericidal activity in familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) syndrome caused by STXBP2/Munc18-2 mutations.

Zhao XW, Gazendam RP, Drewniak A, van Houdt M, Tool AT, van Hamme JL, Kustiawan I, Meijer AB, Janssen H, Russell DG, van de Corput L, Tesselaar K, Boelens JJ, Kuhnle I, Van Der Werff Ten Bosch J, Kuijpers TW, van den Berg TK.

Blood. 2013 Jul 4;122(1):109-11. doi: 10.1182/blood-2013-03-494039. Epub 2013 May 17.

PMID:
23687090
[PubMed - indexed for MEDLINE]
Free Article
18.

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells.

Côte M, Ménager MM, Burgess A, Mahlaoui N, Picard C, Schaffner C, Al-Manjomi F, Al-Harbi M, Alangari A, Le Deist F, Gennery AR, Prince N, Cariou A, Nitschke P, Blank U, El-Ghazali G, Ménasché G, Latour S, Fischer A, de Saint Basile G.

J Clin Invest. 2009 Dec;119(12):3765-73. doi: 10.1172/JCI40732. Epub 2009 Nov 2.

PMID:
19884660
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

[Screening for cytotoxic defects with flow cytometric detection of CD107α on natural killer cells and cytotoxic lymphocyte cells].

Wang J, Liu Z, Jiang LP, An YF, Zhao XD.

Zhonghua Er Ke Za Zhi. 2012 May;50(5):386-91. Chinese.

PMID:
22883044
[PubMed - indexed for MEDLINE]
20.

STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5.

Cetica V, Santoro A, Gilmour KC, Sieni E, Beutel K, Pende D, Marcenaro S, Koch F, Grieve S, Wheeler R, Zhao F, zur Stadt U, Griffiths GM, Aricò M.

J Med Genet. 2010 Sep;47(9):595-600. doi: 10.1136/jmg.2009.075341.

PMID:
20798128
[PubMed - indexed for MEDLINE]

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