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Results: 1 to 20 of 96

1.

Augmentation of therapeutic responses in melanoma by inhibition of IRAK-1,-4.

Srivastava R, Geng D, Liu Y, Zheng L, Li Z, Joseph MA, McKenna C, Bansal N, Ochoa A, Davila E.

Cancer Res. 2012 Dec 1;72(23):6209-16. doi: 10.1158/0008-5472.CAN-12-0337. Epub 2012 Oct 4.

PMID:
23041547
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors.

De Nardo D, Masendycz P, Ho S, Cross M, Fleetwood AJ, Reynolds EC, Hamilton JA, Scholz GM.

J Biol Chem. 2005 Mar 18;280(11):9813-22. Epub 2005 Jan 12.

PMID:
15647277
[PubMed - indexed for MEDLINE]
Free Article
3.

The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells.

Song KW, Talamas FX, Suttmann RT, Olson PS, Barnett JW, Lee SW, Thompson KD, Jin S, Hekmat-Nejad M, Cai TZ, Manning AM, Hill RJ, Wong BR.

Mol Immunol. 2009 Apr;46(7):1458-66. doi: 10.1016/j.molimm.2008.12.012. Epub 2009 Jan 31.

PMID:
19181383
[PubMed - indexed for MEDLINE]
4.

Regulation of IRAK-1 activation by its C-terminal domain.

Nguyen T, De Nardo D, Masendycz P, Hamilton JA, Scholz GM.

Cell Signal. 2009 May;21(5):719-26. doi: 10.1016/j.cellsig.2009.01.010. Epub 2009 Jan 7.

PMID:
19166926
[PubMed - indexed for MEDLINE]
5.

Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro.

Yang YF, Chen Z, Hu SL, Hu J, Li B, Li JT, Wei LJ, Qian ZM, Lin JK, Feng H, Zhu G.

Neuroscience. 2011 Nov 24;196:25-34. doi: 10.1016/j.neuroscience.2011.08.059. Epub 2011 Sep 10.

PMID:
21925238
[PubMed - indexed for MEDLINE]
6.

Down-regulation of IRAK-4 is a component of LPS- and CpG DNA-induced tolerance in macrophages.

De Nardo D, Nguyen T, Hamilton JA, Scholz GM.

Cell Signal. 2009 Feb;21(2):246-52. doi: 10.1016/j.cellsig.2008.10.009. Epub 2008 Oct 25.

PMID:
18992325
[PubMed - indexed for MEDLINE]
7.

IRAK-M is a negative regulator of Toll-like receptor signaling.

Kobayashi K, Hernandez LD, Galán JE, Janeway CA Jr, Medzhitov R, Flavell RA.

Cell. 2002 Jul 26;110(2):191-202.

PMID:
12150927
[PubMed - indexed for MEDLINE]
Free Article
8.

IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression.

Koziczak-Holbro M, Joyce C, Glück A, Kinzel B, Müller M, Tschopp C, Mathison JC, Davis CN, Gram H.

J Biol Chem. 2007 May 4;282(18):13552-60. Epub 2007 Mar 2.

PMID:
17337443
[PubMed - indexed for MEDLINE]
Free Article
9.

IRAK-4 inhibitors for inflammation.

Wang Z, Wesche H, Stevens T, Walker N, Yeh WC.

Curr Top Med Chem. 2009;9(8):724-37. Review.

PMID:
19689377
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy.

Augustine CK, Toshimitsu H, Jung SH, Zipfel PA, Yoo JS, Yoshimoto Y, Selim MA, Burchette J, Beasley GM, McMahon N, Padussis J, Pruitt SK, Ali-Osman F, Tyler DS.

Mol Cancer Ther. 2010 Jul;9(7):2090-101. doi: 10.1158/1535-7163.MCT-10-0073. Epub 2010 Jun 22.

PMID:
20571072
[PubMed - indexed for MEDLINE]
Free Article
11.

The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals.

Williams KL, Lich JD, Duncan JA, Reed W, Rallabhandi P, Moore C, Kurtz S, Coffield VM, Accavitti-Loper MA, Su L, Vogel SN, Braunstein M, Ting JP.

J Biol Chem. 2005 Dec 2;280(48):39914-24. Epub 2005 Oct 3.

PMID:
16203735
[PubMed - indexed for MEDLINE]
Free Article
12.

IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination.

Keating SE, Maloney GM, Moran EM, Bowie AG.

J Biol Chem. 2007 Nov 16;282(46):33435-43. Epub 2007 Sep 18.

PMID:
17878161
[PubMed - indexed for MEDLINE]
Free Article
13.

Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha.

Flannery SM, Keating SE, Szymak J, Bowie AG.

J Biol Chem. 2011 Jul 8;286(27):23688-97. doi: 10.1074/jbc.M111.248351. Epub 2011 May 23.

PMID:
21606490
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.

Flannery S, Bowie AG.

Biochem Pharmacol. 2010 Dec 15;80(12):1981-91. doi: 10.1016/j.bcp.2010.06.020. Epub 2010 Jun 23. Review.

PMID:
20599782
[PubMed - indexed for MEDLINE]
15.

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

Ku CL, von Bernuth H, Picard C, Zhang SY, Chang HH, Yang K, Chrabieh M, Issekutz AC, Cunningham CK, Gallin J, Holland SM, Roifman C, Ehl S, Smart J, Tang M, Barrat FJ, Levy O, McDonald D, Day-Good NK, Miller R, Takada H, Hara T, Al-Hajjar S, Al-Ghonaium A, Speert D, Sanlaville D, Li X, Geissmann F, Vivier E, Maródi L, Garty BZ, Chapel H, Rodriguez-Gallego C, Bossuyt X, Abel L, Puel A, Casanova JL.

J Exp Med. 2007 Oct 1;204(10):2407-22. Epub 2007 Sep 24.

PMID:
17893200
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Pharmacologic synergy between dual phosphoinositide-3-kinase and mammalian target of rapamycin inhibition and 5-fluorouracil in PIK3CA mutant gastric cancer cells.

Bhattacharya B, Akram M, Balasubramanian I, Tam KK, Koh KX, Yee MQ, Soong R.

Cancer Biol Ther. 2012 Jan 1;13(1):34-42. doi: 10.4161/cbt.13.1.18437.

PMID:
22336586
[PubMed - indexed for MEDLINE]
17.

IRAK-1-mediated negative regulation of Toll-like receptor signaling through proteasome-dependent downregulation of TRAF6.

Muroi M, Tanamoto K.

Biochim Biophys Acta. 2012 Feb;1823(2):255-63. doi: 10.1016/j.bbamcr.2011.10.003. Epub 2011 Oct 18.

PMID:
22033459
[PubMed - indexed for MEDLINE]
Free Article
18.

Antitumor activity of YM155, a selective small-molecule survivin suppressant, alone and in combination with docetaxel in human malignant melanoma models.

Yamanaka K, Nakahara T, Yamauchi T, Kita A, Takeuchi M, Kiyonaga F, Kaneko N, Sasamata M.

Clin Cancer Res. 2011 Aug 15;17(16):5423-31. doi: 10.1158/1078-0432.CCR-10-3410. Epub 2011 Jul 7.

PMID:
21737502
[PubMed - indexed for MEDLINE]
Free Article
19.

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.

Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada H, Wakeham A, Itie A, Li S, Penninger JM, Wesche H, Ohashi PS, Mak TW, Yeh WC.

Nature. 2002 Apr 18;416(6882):750-6. Epub 2002 Mar 31.

PMID:
11923871
[PubMed - indexed for MEDLINE]
20.

Up-regulation of IRAK-M is essential for endotoxin tolerance induced by a low dose of lipopolysaccharide in Kupffer cells.

Liu ZJ, Yan LN, Li XH, Xu FL, Chen XF, You HB, Gong JP.

J Surg Res. 2008 Nov;150(1):34-9. doi: 10.1016/j.jss.2007.12.759. Epub 2008 Jan 10.

PMID:
18533191
[PubMed - indexed for MEDLINE]

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