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Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance.

Robbins N, Leach MD, Cowen LE.

Cell Rep. 2012 Oct 25;2(4):878-88. doi: 10.1016/j.celrep.2012.08.035. Epub 2012 Oct 4.


Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.

Singh SD, Robbins N, Zaas AK, Schell WA, Perfect JR, Cowen LE.

PLoS Pathog. 2009 Jul;5(7):e1000532. doi: 10.1371/journal.ppat.1000532. Epub 2009 Jul 31.


PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.

LaFayette SL, Collins C, Zaas AK, Schell WA, Betancourt-Quiroz M, Gunatilaka AA, Perfect JR, Cowen LE.

PLoS Pathog. 2010 Aug 26;6(8):e1001069. doi: 10.1371/journal.ppat.1001069.


The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance.

Shapiro RS, Zaas AK, Betancourt-Quiroz M, Perfect JR, Cowen LE.

PLoS One. 2012;7(9):e44734. doi: 10.1371/journal.pone.0044734. Epub 2012 Sep 6.


Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations.

Hill JA, Ammar R, Torti D, Nislow C, Cowen LE.

PLoS Genet. 2013 Apr;9(4):e1003390. doi: 10.1371/journal.pgen.1003390. Epub 2013 Apr 4.


Hsp90 governs dispersion and drug resistance of fungal biofilms.

Robbins N, Uppuluri P, Nett J, Rajendran R, Ramage G, Lopez-Ribot JL, Andes D, Cowen LE.

PLoS Pathog. 2011 Sep;7(9):e1002257. doi: 10.1371/journal.ppat.1002257. Epub 2011 Sep 8.


Metabolic control of antifungal drug resistance.

Robbins N, Collins C, Morhayim J, Cowen LE.

Fungal Genet Biol. 2010 Feb;47(2):81-93. doi: 10.1016/j.fgb.2009.07.004. Epub 2009 Jul 10.


Genetic architecture of Hsp90-dependent drug resistance.

Cowen LE, Carpenter AE, Matangkasombut O, Fink GR, Lindquist S.

Eukaryot Cell. 2006 Dec;5(12):2184-8. Epub 2006 Oct 20.


The Rpd3/Hda1 family of histone deacetylases regulates azole resistance in Candida albicans.

Li X, Cai Q, Mei H, Zhou X, Shen Y, Li D, Liu W.

J Antimicrob Chemother. 2015 Jul;70(7):1993-2003. doi: 10.1093/jac/dkv070. Epub 2015 Mar 29.


Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.

Cowen LE, Lindquist S.

Science. 2005 Sep 30;309(5744):2185-9.


Hsp90 is involved in apoptosis of Candida albicans by regulating the calcineurin-caspase apoptotic pathway.

Dai B, Wang Y, Li D, Xu Y, Liang R, Zhao L, Cao Y, Jia J, Jiang Y.

PLoS One. 2012;7(9):e45109. doi: 10.1371/journal.pone.0045109. Epub 2012 Sep 18.


Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry.

Diezmann S, Michaut M, Shapiro RS, Bader GD, Cowen LE.

PLoS Genet. 2012;8(3):e1002562. doi: 10.1371/journal.pgen.1002562. Epub 2012 Mar 15.


Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus.

Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Asfaw YG, Steinbach WJ.

Antimicrob Agents Chemother. 2014;58(4):1889-96. doi: 10.1128/AAC.02286-13. Epub 2014 Jan 6.


Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.

Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.

Mol Cell Proteomics. 2012 Nov;11(11):1510-22. doi: 10.1074/mcp.M112.017251. Epub 2012 Aug 2.


HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription.

Rundlett SE, Carmen AA, Kobayashi R, Bavykin S, Turner BM, Grunstein M.

Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14503-8.


Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata.

Singh-Babak SD, Babak T, Diezmann S, Hill JA, Xie JL, Chen YL, Poutanen SM, Rennie RP, Heitman J, Cowen LE.

PLoS Pathog. 2012;8(5):e1002718. doi: 10.1371/journal.ppat.1002718. Epub 2012 May 17.

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