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A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer.

Margalef P, Fernández-Majada V, Villanueva A, Garcia-Carbonell R, Iglesias M, López L, Martínez-Iniesta M, Villà-Freixa J, Mulero MC, Andreu M, Torres F, Mayo MW, Bigas A, Espinosa L.

Cell Rep. 2012 Oct 25;2(4):840-54. doi: 10.1016/j.celrep.2012.08.028. Epub 2012 Oct 4.


Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer.

Fernández-Majada V, Aguilera C, Villanueva A, Vilardell F, Robert-Moreno A, Aytés A, Real FX, Capella G, Mayo MW, Espinosa L, Bigas A.

Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):276-81. Epub 2006 Dec 26. Erratum in: Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5650.


BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent.

Margalef P, Colomer C, Villanueva A, Montagut C, Iglesias M, Bellosillo B, Salazar R, Martínez-Iniesta M, Bigas A, Espinosa L.

Sci Signal. 2015 Apr 21;8(373):ra38. doi: 10.1126/scisignal.2005886.


Hepatitis B virus X protein induces IKKα nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells.

Huang WC, Chen WS, Chen YJ, Wang LY, Hsu SC, Chen CC, Hung MC.

J Cell Physiol. 2012 Apr;227(4):1446-54. doi: 10.1002/jcp.22860.


Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity.

Xue J, Li X, Jiao S, Wei Y, Wu G, Fang J.

Gastroenterology. 2010 Feb;138(2):606-15. doi: 10.1053/j.gastro.2009.09.049. Epub 2009 Sep 26.


Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.

Song LL, Peng Y, Yun J, Rizzo P, Chaturvedi V, Weijzen S, Kast WM, Stone PJ, Santos L, Loredo A, Lendahl U, Sonenshein G, Osborne B, Qin JZ, Pannuti A, Nickoloff BJ, Miele L.

Oncogene. 2008 Oct 2;27(44):5833-44. doi: 10.1038/onc.2008.190. Epub 2008 Jun 16.


Cells lacking IKKα show nuclear cyclin D1 overexpression and a neoplastic phenotype: role of IKKα as a tumor suppressor.

Kwak YT, Radaideh SM, Ding L, Li R, Frenkel E, Story MD, Girard L, Minna J, Verma UN.

Mol Cancer Res. 2011 Mar;9(3):341-9. doi: 10.1158/1541-7786.MCR-10-0248. Epub 2011 Feb 11.


IkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation.

Kwak YT, Li R, Becerra CR, Tripathy D, Frenkel EP, Verma UN.

J Biol Chem. 2005 Oct 7;280(40):33945-52. Epub 2005 Aug 15. Erratum in: J Biol Chem. 2005 Nov 18;280(46):38888.


Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding.

Gloire G, Horion J, El Mjiyad N, Bex F, Chariot A, Dejardin E, Piette J.

J Biol Chem. 2007 Jul 20;282(29):21308-18. Epub 2007 May 30.


IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300.

Hoberg JE, Popko AE, Ramsey CS, Mayo MW.

Mol Cell Biol. 2006 Jan;26(2):457-71.


A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes.

Scotto d'Abusco A, Politi L, Giordano C, Scandurra R.

Arthritis Res Ther. 2010;12(1):R18. doi: 10.1186/ar2920. Epub 2010 Jan 29.


Nuclear legumain activity in colorectal cancer.

Haugen MH, Johansen HT, Pettersen SJ, Solberg R, Brix K, Flatmark K, Maelandsmo GM.

PLoS One. 2013;8(1):e52980. doi: 10.1371/journal.pone.0052980. Epub 2013 Jan 10. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/05c95441-890f-4707-a1bc-c4d386561191.


p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription.

Chiacchiera F, Matrone A, Ferrari E, Ingravallo G, Lo Sasso G, Murzilli S, Petruzzelli M, Salvatore L, Moschetta A, Simone C.

Cell Death Differ. 2009 Sep;16(9):1203-14. doi: 10.1038/cdd.2009.36. Epub 2009 Apr 3.


Regulation and function of IKK and IKK-related kinases.

Häcker H, Karin M.

Sci STKE. 2006 Oct 17;2006(357):re13. Review.


The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells.

Li XB, Jiao S, Sun H, Xue J, Zhao WT, Fan L, Wu GH, Fang J.

Cancer Lett. 2011 Oct 28;309(2):137-44. doi: 10.1016/j.canlet.2011.05.025. Epub 2011 Jun 22.


Targeting of colorectal cancer growth, metastasis, and anti-apoptosis in BALB/c nude mice via APRIL siRNA.

Wang J, Ding W, Sun B, Jing R, Huang H, Shi G, Wang H.

Mol Cell Biochem. 2012 Apr;363(1-2):1-10. doi: 10.1007/s11010-011-1151-4. Epub 2011 Dec 15.


Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.

Liu B, Yang Y, Chernishof V, Loo RR, Jang H, Tahk S, Yang R, Mink S, Shultz D, Bellone CJ, Loo JA, Shuai K.

Cell. 2007 Jun 1;129(5):903-14.


[Influence of inhibitory KappaB protein kinase alpha and gamma genes silencing induced by RNA interference on nuclear factor-KappaB signal pathway].

Chen HL, Li HL, Zhang GX, Li H, Liu J, He XM.

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Mar;21(3):131-4. Chinese.

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