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TAp63 is a master transcriptional regulator of lipid and glucose metabolism.

Su X, Gi YJ, Chakravarti D, Chan IL, Zhang A, Xia X, Tsai KY, Flores ER.

Cell Metab. 2012 Oct 3;16(4):511-25. doi: 10.1016/j.cmet.2012.09.006.


α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase.

Chen WL, Kang CH, Wang SG, Lee HM.

Diabetologia. 2012 Jun;55(6):1824-35. doi: 10.1007/s00125-012-2530-4. Epub 2012 Mar 30.


SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.

Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M.

J Biol Chem. 2008 Jul 18;283(29):20015-26. doi: 10.1074/jbc.M802187200. Epub 2008 May 14.


Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice.

Li H, Xu M, Lee J, He C, Xie Z.

Am J Physiol Endocrinol Metab. 2012 Nov 15;303(10):E1234-44. doi: 10.1152/ajpendo.00198.2012. Epub 2012 Sep 11.


Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice.

Lee J, Hong SW, Chae SW, Kim DH, Choi JH, Bae JC, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Kim SW, Lee WY.

PLoS One. 2012;7(2):e31394. doi: 10.1371/journal.pone.0031394. Epub 2012 Feb 17.


Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway.

Chau MD, Gao J, Yang Q, Wu Z, Gromada J.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12553-8. doi: 10.1073/pnas.1006962107. Epub 2010 Jun 28.


Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice.

Shen Z, Liang X, Rogers CQ, Rideout D, You M.

Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G364-74. doi: 10.1152/ajpgi.00456.2009. Epub 2009 Dec 10.


Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.

Cantó C, Jiang LQ, Deshmukh AS, Mataki C, Coste A, Lagouge M, Zierath JR, Auwerx J.

Cell Metab. 2010 Mar 3;11(3):213-9. doi: 10.1016/j.cmet.2010.02.006.


3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent pathway.

Pil Hwang Y, Gyun Kim H, Choi JH, Truong Do M, Tran TP, Chun HK, Chung YC, Jeong TC, Jeong HG.

Mol Nutr Food Res. 2013 Mar;57(3):471-82. doi: 10.1002/mnfr.201200529. Epub 2013 Jan 24.


LKB1 regulates lipid oxidation during exercise independently of AMPK.

Jeppesen J, Maarbjerg SJ, Jordy AB, Fritzen AM, Pehmøller C, Sylow L, Serup AK, Jessen N, Thorsen K, Prats C, Qvortrup K, Dyck JR, Hunter RW, Sakamoto K, Thomson DM, Schjerling P, Wojtaszewski JF, Richter EA, Kiens B.

Diabetes. 2013 May;62(5):1490-9. doi: 10.2337/db12-1160. Epub 2013 Jan 24.


Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1-AMPK signaling pathway.

Yu JW, Sun LJ, Liu W, Zhao YH, Kang P, Yan BZ.

Int J Infect Dis. 2013 Jul;17(7):e539-45. doi: 10.1016/j.ijid.2013.01.027. Epub 2013 Mar 16.


Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1.

Rodgers JT, Puigserver P.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12861-6. Epub 2007 Jul 23.


Does LKB1 mediate activation of hepatic AMP-protein kinase (AMPK) and sirtuin1 (SIRT1) after Roux-en-Y gastric bypass in obese rats?

Peng Y, Rideout DA, Rakita SS, Gower WR Jr, You M, Murr MM.

J Gastrointest Surg. 2010 Feb;14(2):221-8. doi: 10.1007/s11605-009-1102-5.


SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells.

Zu Y, Liu L, Lee MY, Xu C, Liang Y, Man RY, Vanhoutte PM, Wang Y.

Circ Res. 2010 Apr 30;106(8):1384-93. doi: 10.1161/CIRCRESAHA.109.215483. Epub 2010 Mar 4.


Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex.

Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P.

J Biol Chem. 2013 Mar 8;288(10):7117-26. doi: 10.1074/jbc.M112.415729. Epub 2013 Jan 17.


Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1.

Yang Z, Kahn BB, Shi H, Xue BZ.

J Biol Chem. 2010 Jun 18;285(25):19051-9. doi: 10.1074/jbc.M110.123620. Epub 2010 Apr 26.


Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1α axis in db/db mice.

Kim MY, Lim JH, Youn HH, Hong YA, Yang KS, Park HS, Chung S, Ko SH, Shin SJ, Choi BS, Kim HW, Kim YS, Lee JH, Chang YS, Park CW.

Diabetologia. 2013 Jan;56(1):204-17. doi: 10.1007/s00125-012-2747-2. Epub 2012 Oct 23. Erratum in: Diabetologia. 2013 Mar;56(3):681. Koh, S H [corrected to Ko, S H].


AMP-activated protein kinase in metabolic control and insulin signaling.

Towler MC, Hardie DG.

Circ Res. 2007 Feb 16;100(3):328-41. Review.


[Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases].

Foretz M, Taleux N, Guigas B, Horman S, Beauloye C, Andreelli F, Bertrand L, Viollet B.

Med Sci (Paris). 2006 Apr;22(4):381-8. Review. French.


A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells.

Nelson LE, Valentine RJ, Cacicedo JM, Gauthier MS, Ido Y, Ruderman NB.

Am J Physiol Cell Physiol. 2012 Jul 1;303(1):C4-C13. doi: 10.1152/ajpcell.00296.2011. Epub 2012 Feb 29.

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